Particles containing a lipid matrix core and active ingredient
A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.
1 . A composition comprising:
a plurality of particles, wherein each of the plurality of particles comprises a core having a lipid matrix with an active ingredient dispersed therein, wherein the active ingredient comprises a fat-soluble active ingredient and at least one outer layer disposed on the core, wherein the fat-soluble active ingredient comprises one or more carotenoids and wherein the at least one outer layer comprises at least one second active ingredient layer.
2 . The composition of claim 1 , wherein the active ingredient comprises from about 10% to about 60% by weight of the core.
3 . The composition of claim 1 , wherein the one or more carotenoids are selected from the group consisting of lutein, astaxanthin, zeaxanthin, alpha-carotene, beta-carotene, cryptoxanthin, lycopene, and mixtures thereof.
4 . The composition of claim 1 , wherein the core is solid at ambient temperature.
5 . The composition of claim 1 , wherein the core has a mean diameter ranging from about 40 μm to about 3000 μm.
6 . The composition of claim 1 , wherein the lipid matrix comprises at least one low flow point excipient and at least one high flow point excipient.
7 . The composition claim 1 , wherein the at least one outer layer comprises one or more adhesives and one or more active ingredients.
8 . The composition of claim 1 , wherein the at least one second active ingredient comprises one or more fat-soluble vitamins or minerals, one or more water soluble vitamins or minerals, and combinations thereof.
9 . The composition of claim 1 , wherein the core comprises about 5% to about 60% by weight of the plurality of particles.
10 . The composition of claim 1 , wherein the one or more particles comprise an average diameter of from about 0.5 mm to about 1.5 mm.
11 . The composition of claim 1 , further comprising an outermost layer comprised of a coating material for sealing each of the plurality of particles.
12 . The composition of claim 1 , wherein the plurality of particles further contain one or more adjuvants chosen from anti-adherents, binders, coatings, colors, disintegrants, fillers, flavoring agents, glidants, lubricants, preservatives, sorbents, sweeteners, vehicles, vitamins, and the like.