Granted Patent B2

US 12,465,892 · App. 18/239,352 · Granted Nov 11, 2025

Inventors: Takeshi Sato (Kanagawa, JP); Renjo Takama (Kanagawa, JP)

Assignee: TERUMO KABUSHIKI KAISHA

B01D65/102B01D63/02

Abstract

Claims (27)

1 . A method for evaluating a covering state of a silicone compound on a hollow fiber membrane for treating blood in an oxygenator, comprising the steps of:

dissolving a silicone compound and a dyeing agent in an organic solvent to prepare a coating solution;

causing the coating solution to pass through an inner surface of a hollow fiber membrane to form a coating layer containing the silicone compound and/or a crosslinked product of the silicone compound and the dyeing agent on the inner surface; and

evaluating a covering state of the silicone compound/the crosslinked product by observing a dyed state of a hollow fiber membrane end surface on a coating solution passing start side and a dyed state of a hollow fiber membrane end surface on a coating solution passing end side of the hollow fiber membrane on which the coating layer is formed.

2 . The method according to claim 1 , wherein the dyeing agent is selected from Rhodamine B, Rhodamine 6G, Rhodamine 6GP, Rhodamine 3GO, Rhodamine 123, fluorescein and a derivative thereof, and a polymer having these molecules in at least one of a side chain and a terminal.

3 . The method according to claim 1 , wherein a surface tension of the organic solvent is less than 70 dyn/cm.

4 . The method according to claim 3 , wherein the organic solvent is at least one selected from the group consisting of n-hexane, cyclohexane, acetone, butyl alcohol, 1-propanol, isopropanol, chloroform, diethyl ether, an aromatic hydrocarbon, and a fluorine-based solvent.

5 . The method according to claim 1 , wherein at least a part of the hollow fiber membrane is formed of a polypropylene or polymethylpentene.

6 . The method according to claim 1 , wherein the silicone compound is represented by the following Formula (1):

and wherein in the above Formula (1), R 1 to R 8 each independently represent an alkyl group having 1 or more and 6 or less carbon atoms, an aromatic hydrocarbon group having 6 or more and 30 or less carbon atoms, or a reactive group selected from the group consisting of an ethylenically unsaturated bond-containing group having 1 or more and 6 or less carbon atoms, an amino group-containing group, a hydroxy group-containing group, a carboxy group-containing group, a maleimide group-containing group, a thiol group-containing group, and a halogen group; and n is 1 or more and 100,000 or less.

7 . A method for evaluating a covering state of a silicone compound on a bundle of a plurality of hollow fiber membranes for treating blood in an oxygenator, comprising the steps of:

dissolving a silicone compound and a dyeing agent in an organic solvent to prepare a coating solution;

causing the coating solution to pass through an inner surface of the hollow fiber membranes in the bundle to form a coating layer containing the silicone compound and/or a crosslinked product of the silicone compound and the dyeing agent on the inner surface; and

evaluating a covering state of the silicone compound/the crosslinked product of each hollow fiber membrane by observing a dyed state of a hollow fiber membrane end surface on a coating solution passing start side and a dyed state of a hollow fiber membrane end surface on a coating solution passing end side of the hollow fiber membrane on which the coating layer is formed;

counting a number of the hollow fiber membranes with the dyed state at their coating solution passing end side; and

calculating a dyeing ratio according to the number of hollow fiber membranes within the bundle which are dyed on the coating solution passing end side and a number of hollow fiber membranes dyed on the coating solution passing start side.

8 . The method according to claim 7 , further comprising the steps of:

determining a failure of the bundle of hollow fiber membranes when the calculated dyeing ratio is less than a predetermined percentage; and

determining a pass of the bundle of hollow fiber membranes when the calculated dyeing ratio is greater than the predetermined percentage.

9 . The method according to claim 8 , wherein the predetermined percentage is about 90%.

10 . The method according to claim 8 , wherein the predetermined percentage is about 95%.

11 . The method according to claim 7 , wherein the dyeing agent is selected from Rhodamine B, Rhodamine 6G, Rhodamine 6GP, Rhodamine 3GO, Rhodamine 123, fluorescein and a derivative thereof, and a polymer having these molecules in at least one of a side chain and a terminal.

12 . The method according to claim 7 , wherein a surface tension of the organic solvent is less than 70 dyn/cm.

13 . The method according to claim 12 , wherein the organic solvent is at least one selected from the group consisting of n-hexane, cyclohexane, acetone, butyl alcohol, 1-propanol, isopropanol, chloroform, diethyl ether, an aromatic hydrocarbon, and a fluorine-based solvent.

14 . The method according to claim 7 , wherein at least a part of the hollow fiber membranes is formed of a polypropylene or polymethylpentene.

15 . The method according to claim 7 , wherein the silicone compound is represented by the following Formula (1):

and wherein in the above Formula (1), R 1 to R 8 each independently represent an alkyl group having 1 or more and 6 or less carbon atoms, an aromatic hydrocarbon group having 6 or more and 30 or less carbon atoms, or a reactive group selected from the group consisting of an ethylenically unsaturated bond-containing group having 1 or more and 6 or less carbon atoms, an amino group-containing group, a hydroxy group-containing group, a carboxy group-containing group, a maleimide group-containing group, a thiol group-containing group, and a halogen group; and n is 1 or more and 100,000 or less.

Assignments (2)

Priority Claims (1)

Continuity (2)

References Cited (15)