Oxygenator and method for manufacturing same
An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.
1 . A method for manufacturing an oxygenator having a plurality of porous hollow fiber membranes for gas exchange, the method comprising the steps of:
dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution; and
bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface.
2 . The method according to claim 1 , wherein the organic solvent is at least one selected from the group consisting of n-hexane, cyclohexane, acetone, butyl alcohol, 1-propanol, isopropanol, chloroform, diethyl ether, aromatic hydrocarbon, and fluorine-based solvent.
3 . The method according to claim 1 , wherein the hollow fiber membranes are comprised of polypropylene or polymethylpentene.
4 . The method according to claim 1 , further comprising the step of:
forming an antithrombotic polymer compound-containing coat on an outer surface of the hollow fiber membranes.
5 . The method according to claim 1 , wherein the silicone compound is represented by a Formula (1):
wherein R 1 to R 8 are each independently a C 1-6 alkyl group, a C 6-30 aromatic hydrocarbon group, or a reactive group selected from the group consisting of ethylenically unsaturated bond, amino group, hydroxy group, carboxy group, maleimide group, thiol group, and halogen group; and
wherein n is 1 or more and 100,000 or less.
6 . A method for manufacturing an oxygenator having a plurality of porous hollow fiber membranes for gas exchange, the method comprising the steps of:
dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution;
exposing an inner surface of the hollow fiber membranes to the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less; and
drying the organic solvent;
wherein the exposing and drying steps are sequentially repeated a plurality of times to form a silicone compound-containing coating layer on the inner surface.
7 . The method according to claim 6 , wherein the organic solvent is at least one selected from the group consisting of n-hexane, cyclohexane, acetone, butyl alcohol, 1-propanol, isopropanol, chloroform, diethyl ether, aromatic hydrocarbon, and fluorine-based solvent.
8 . The method according to claim 6 , wherein the hollow fiber membranes are comprised of polypropylene or polymethylpentene.
9 . The method according to claim 6 , further comprising the step of:
forming an antithrombotic polymer compound-containing coat on an outer surface of the hollow fiber membranes.
10 . The method according to claim 6 , wherein the silicone compound is represented by a Formula (1):
wherein R 1 to R 8 are each independently a C 1-6 alkyl group, a C 6-30 aromatic hydrocarbon group, or a reactive group selected from the group consisting of ethylenically unsaturated bond, amino group, hydroxy group, carboxy group, maleimide group, thiol group, and halogen group; and
wherein n is 1 or more and 100,000 or less.