Method for maintaining skin corneum layer completeness, promoting hyaluronic acid production, improving skin cell mitochondrion activity and/ or promoting skin cell proliferation by using bacterial lysate of
A method for maintaining skin corneum layer completeness, promoting hyaluronic acid production, improving skin cell mitochondrion activity and/or promoting skin cell proliferation in a subject in need thereof, includes administering to the subject a composition including bacterial lysate of a H. trueperi TCI66207 strain. The Halobacillus trueperi TCI66207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381.
1 . A method for maintaining skin corneum layer completeness and/or promoting hyaluronic acid production in a subject in need thereof, comprising administering to the subject a composition comprising bacterial lysate of a H. trueperi TC166207 strain, wherein the H. trueperi TC166207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381.
2 . The method according to claim 1 , wherein the bacterial lysate of the H. trueperi TCI66207 strain increases expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes.
3 . The method according to claim 1 , wherein the composition is capable of reducing wrinkles of the subject.
4 . The method according to claim 1 , wherein the composition is capable of relieving skin sagging of the subject.
5 . The method according to claim 1 , wherein the composition is a pharmaceutical composition or a cosmetic composition.
6 . A method for improving skin cell mitochondrion activity in a subject in need thereof, comprising administering to the subject a composition comprising bacterial lysate of a H. trueperi TC166207 strain, wherein the H. trueperi TC166207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381.
7 . The method according to claim 6 , wherein the bacterial lysate of the H. trueperi TCI66207 strain increases expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes.
8 . The method according to claim 6 , wherein the composition is capable of enhancing water-retention capacity of the subject.
9 . The method according to claim 6 , wherein the composition is a pharmaceutical composition or a cosmetic composition.
10 . A method for promoting skin cell proliferation in a subject in need thereof, comprising administering to the subject a composition comprising bacterial lysate of a H. trueperi TC166207 strain, wherein the H. trueperi TC166207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381.
11 . The method according to claim 10 , wherein the bacterial lysate of the H. trueperi TCI66207 strain increases expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes.
12 . The method according to claim 10 , wherein the composition is capable of reducing wrinkles of the subject.
13 . The method according to claim 10 , wherein the composition is capable of relieving skin sagging of the subject.
14 . The method according to claim 10 , wherein the composition is a pharmaceutical composition or a cosmetic composition.