Inhibitors of erythrocyte band 3 tyrosine phosphorylation and uses thereof
Inhibitors of erythrocyte band 3 tyrosine phosphorylation of formula (I), and pharmaceutical salts thereof, are described: wherein R 1 -R 3 are defined herein. Compositions comprising compounds of the formula (I), and methods of using the compounds and compositions comprising the compounds to treat sickle cell diseases are also described.
1 . A compound of formula (I):
wherein:
R 1 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R 2 is halogen; and
R 3 is
or a pharmaceutically acceptable salt thereof.
2 . The compound of claim 1 , wherein R 1 is
3 . The compound of claim 1 wherein R 1 is
4 . The compound of claim 1 , wherein R 2 is F.
5 . The compound of claim 1 , wherein the compound of formula (I) is
6 . The compound of claim 1 , wherein the compound of formula (I) is selected from
7 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutical acceptable carrier.
8 . A method of treating sickle cell disease in a subject suffering therefrom, which method comprises administering to the subject a therapeutically effective amount of a compound of claim 1 or a pharmaceutical composition comprising same and a pharmaceutically acceptable carrier.