IP Library › Granted Patent US 12,474,158
Granted Patent B2
US 12,474,158 · App. 18/509,739 · Granted Nov 18, 2025

Microresonator-frequency-comb-based platform for clinical high-resolution optical coherence tomography

Inventors: Michal Lipson (New York, NY); Xingchen Ji (New York, NY); Alexander Klenner (New York, NY); Xinwen Yao (Baltimore, MD); Yu Gan (Harriston, NJ); Alexander L. Gaeta (New York, NY); Christine P. Hendon (Bronx, NY)
Assignee: The Trustees of Columbia University in the City of New York
G01B9/02008G01B9/02091
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Quick Facts
Patent No.
US 12,474,158
App. No.
18/509,739
Granted
Nov 18, 2025
Kind
B2
Abstract

A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source.

Claims (23)

1 . A device comprising:

a chip comprising a substrate; and

a resonator disposed on the chip and configured to generate a frequency comb in a non-phase-locked state based on receiving a pump signal, wherein the resonator is configured to be tuned to control a resonance of the resonator relative to a frequency of the pump signal, and

wherein the chip is configured to integrate with an optical coherence tomography (OCT) system such that the frequency comb is used as an imaging source for the OCT system.

2 . The device of claim 1 , wherein the resonator comprises silicon nitride.

3 . The device of claim 1 , wherein the resonator comprises one or more of silica or silicon.

4 . The device of claim 1 , wherein the resonator comprises one or more of aluminum nitride or crystalline fluoride.

5 . The device of claim 1 , wherein the resonator comprises one or more of diamond or AlGaAs.

6 . The device of claim 1 , wherein the resonator comprises a microresonator.

7 . The device of claim 1 , wherein the resonator comprises a high-Q resonator.

8 . The device of claim 1 , wherein the resonator comprises an ultra high-Q resonator.

9 . The device of claim 1 , further comprising a cladding disposed on the substrate, wherein the resonator is disposed on the cladding.

10 . The device of claim 1 , further comprising a micro-heater configured to provide temperature tuning to control cavity resonance of the resonator.

11 . The device of claim 10 , wherein a micro-heater comprises platinum.

12 . The device of claim 1 , further comprising a laser configured to supply the pump signal to the resonator.

13 . The device of claim 12 , wherein the laser comprises one or more of a distributed feedback (DFB) laser, an external cavity laser, or a Fabry-Perot laser.

14 . The device of claim 1 , further comprising a waveguide configured to supply the pump signal to the resonator.

15 . The device of claim 14 , wherein the waveguide comprises silicon nitride.

16 . The device of claim 1 , wherein the frequency comb has a bandwidth of 110 nm at 30 dB and a line spacing of 38 GHz.

17 . The device of claim 1 , wherein the resonator exhibits a Q of up to 37 million.

18 . The device of claim 1 , wherein the resonator exhibits a Q of up to 8 million.

19 . The device of claim 1 , wherein the resonator exhibits a loss of from 3 dB/m to 1 dB/m.

20 . The device of claim 1 , wherein the resonator exhibits a loss of less than 3 dB/m.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2023
From: LIPSON, MICHAL; JI, XINGCHEN; YAO, XINWEN; GAN, YU; GAETA, ALEXANDER L.; HENDON, CHRISTINE P.
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 065692/0633 →
Continuity (5)
Continuation 17367884 · Jul 6, 2021
Continuation 16100401 · Aug 10, 2018
Provisional Application 62607825 · Dec 19, 2017
Provisional Application 62540412 · Aug 2, 2017
Related Publication 20240302157A1 · Sep 12, 2024
References Cited (80)
US 7519253B2 · Islam · 2009 [cited by applicant]
US 7695140B2 · Fercher · 2010 [cited by applicant]
US 11092424B2 · Lipson · 2021 [cited by examiner]
US 11859972B2 · Lipson · 2024 [cited by examiner]
US 20080018906A1 · Kurokawa et al. · 2008 [cited by applicant]
US 20100220334A1 · Condit et al. · 2010 [cited by applicant]
US 20110235045A1 · Koerner et al. · 2011 [cited by applicant]
US 20110292399A1 · Alphonse · 2011 [cited by applicant]
US 20120177060A1 · Lipson et al. · 2012 [cited by applicant]
US 20150323450A1 · Lipson et al. · 2015 [cited by applicant]
US 20160134078A1 · Gaeta et al. · 2016 [cited by applicant]
US 20180011249A1 · Zhu et al. · 2018 [cited by applicant]
US 20180083414A1 · Weiner et al. · 2018 [cited by applicant]
US 20180205463A1 · Karpov et al. · 2018 [cited by applicant]
US 20190317379A1 · Herr · 2019 [cited by examiner]
US 20190391415A1 · Lipson et al. · 2019 [cited by applicant]
Bajraszewski, Tomasz et al. “Improved spectral optical coherence tomography using optical frequency comb”. Optics Express, vol. 16, No. 6, Mar. 17, 2008, pp. 4163-4176. (Year: 2008). [cited by examiner]
Choi, Samuel et al. “Frequency-comb-based interferometer for profilometry and tomography”. Optics Letters, vol. 31, No. 13, Jul. 1, 2006, pp. 1976-1978. (Year: 2006). [cited by examiner]
Guha, Biswajeet et al. “Athermal silicon microring resonators with titanium oxide cladding”. Optics Express, vol. 21, No. 22, Nov. 4, 2013, pp. 26557-26563. (Year: 2013). [cited by examiner]
Herr, T. et al. “Temporal solitons in optical microresonators”. Nature Photonics 8, pp. 145-152, 2014. (Year: 2014). [cited by examiner]
Adler et al., “Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source,” Optics Express, vol. 12, Issue 10, May 2004, pp. 2112-2119. [cited by applicant]
Assayag et al., “Large Field, High Resolution Full-Field Optical Coherence Tomography,” Technol. Cancer Res. Treat., vol. 13, 2014, pp. 455-468. [cited by applicant]
Coen et al., “Modeling of octave-spanning Kerr frequency combs using a generalized mean-field Lugiato-Lefever model,” Opt. Lett., vol. 38, 2013, pp. 37-39. [cited by applicant]
Corwin et al., “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructured fiber,” Appl. Phys. B., vol. 77, 2003, pp. 269-277. [cited by applicant]
Cundiff et al., “Colloquium: Femtosecond optical frequency combs,” Rev. Mod. Phys., vol. 75, 325, 2003. [cited by applicant]
Del'Haye et al., “Octave Spanning Tunable Frequency Comb from a Microresonator,” Phys. Rev. Lett., vol. 107, 2011. [cited by applicant]
Del'Haye et al., “Optical frequency comb generation from a monolithic microresonator,” Nature 450, 2007, pp. 1214-1217. [cited by applicant]
Diddams et al., “Direct link between microwave and optical frequencies with a 300 THz femtosecond laser comb,” Phys. Rev. Lett., vol. 84, 5102, 2000. [cited by applicant]
Drexler et al., “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett., vol. 24, 1999, pp. 1221-1223. [cited by applicant]
Dutt et al., “Dual-comb spectroscopy using on-chip mode-locked frequency combs,” Photonics.com, Mar. 26, 2013. [cited by applicant]
Dutt et al., “On-chip dual comb source for spectroscopy,” Optics, Nov. 2016. [cited by applicant]
Ferdous et al., “Spectral line-by-line pulse shaping of on-chip microresonator frequency combs,” Nat. Photonics, vol. 5, 2011, pp. 770-776. [cited by applicant]
Froehly et al., “Supercontinuum sources in optical coherence tomography: A state of the art and the application to scan-free time domain correlation techniques and depth dependant dispersion compensation,” Opt. Fiber Te… [cited by applicant]
Gan et al., “Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography,” Biomed. Opt. Express, vol. 6, 2015, pp. 1090-1108. [cited by applicant]
Gan et al., “Automated classification of optical coherence tomography images of human atrial tissue,” J. Biomed. Opt., vol. 21, 2016, pp. 101407-101407. [cited by applicant]
Garcia-Garcia et al., “Virtual histology and optical coherence tomography: from research to a broad clinical application,” Heart, vol. 95, 2009, pp. 1362-1374. [cited by applicant]
Genty et al., “Fiber supercontinuum sources (Invited),” JOSA B., vol. 24, 2007, pp. 1771-1785. [cited by applicant]
Griffith et al., “Coherent mid-infrared frequency combs in silicon-microresonators in the presence of Raman effects,” Optics Express, vol. 24, Issue 12, 2016, pp. 13044-13050. [cited by applicant]
Griffith et al., “Silicon-chip mid-infrared frequency comb generation,” Nat. Commun., 2015, 6: 6299. [cited by applicant]
Grudinin et al., “Generation of optical frequency combs with a CaF 2 resonator,” Opt. Lett., vol. 34, 2009, pp. 878-880. [cited by applicant]
Hausmann et al., “Diamond nonlinear photonics,” Nat. Photonics, vol. 8, 2014, pp. 369-374. [cited by applicant]
Hee et al., “Optical coherence tomography of the human retina,” Arch. Ophthalmol., vol. 113, 1995, pp. 325-332. [cited by applicant]
Herr et al., “Mode Spectrum and Temporal Soliton Formation in Optical Microresonators,” Phys. Rev. Lett., vol. 113, 2014. [cited by applicant]
Herr et al., “Universal formation dynamics and noise of Kerr-frequency combs in microresonators,” Nat. Photonics, vol. 6, 2012, pp. 480-487. [cited by applicant]
Hsiung et al., “Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography,” Radiology, vol. 244, 2007, pp. 865-874. [cited by applicant]
Huang et al., “Optical coherence tomography,” Sci. N. Y. NY 254, 1178 (1991). [cited by applicant]
Huang et al., “Smooth and flat phase-locked Kerr frequency comb generation by higher order mode suppression,” Sci. Rep., vol. 6, 2016. [cited by applicant]
Ikeda et al., “Thermal and Kerr nonlinear properties of plasma-deposited silicon nitride/silicon dioxide waveguides,” Opt. Express, vol. 16, 2008, pp. 12987-12994. [cited by applicant]
Ji et al., “Chip-Based Frequency Combs for High-Resolution Optical Coherence Tomography,” in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optical Society of America, 2018), paper STh1J.4. [cited by applicant]
Ji et al., “Ultra-low-loss on-chip resonators with sub-milliwatt parametric oscillation threshold,” Optics, vol. 4, Issue 6, Jun. 2017, pp. 619-624. [cited by applicant]
Joshi et al., “Thermally controlled comb generation and soliton modelocking in microresonators,” Opt. Lett., vol. 41, 2016, pp. 2565-2568. [cited by applicant]
Jung et al., “Optical frequency comb generation from aluminum nitride microring resonator,” Opt. Lett., vol. 38, 2810, 2013. [cited by applicant]
Kippenberg et al., “Kerr-Nonlinearity Optical Parametric Oscillation in an Ultrahigh-Q Toroid Microcavity,” Phys. Rev. Lett., vol. 93, 2004. [cited by applicant]
Kippenberg et al., “Microresonator-based optical frequency combs,” Science, vol. 332, 2011, pp. 555-559. [cited by applicant]
Klenner et al., “Gigahertz frequency comb offset stabilization based on supercontinuum generation in silicon nitride waveguides,” Optics Express, vol. 24, Issue 10, 2016, pp. 11043-11053. [cited by applicant]
Kuyken et al., “An octave-spanning mid-infrared frequency comb generated in a silicon nanophotonic wire waveguide,” Nat. Commun., vol. 6, 6310, 2015. [cited by applicant]
Lamont et al., “Route to stabilized ultrabroadband microresonator-based frequency combs,” Opt. Lett., vol. 38, 2013, pp. 3478-3481. [cited by applicant]
Lamouche et al., “Intravascular optical coherence tomography on a beating heart model,” J. Biomed. Opt., vol. 15, 046023, 2010. [cited by applicant]
Lee et al., “Optimization for axial resolution, depth range, and sensitivity of spectral domain optical coherence tomography at 1.3 μm,” Journal of the Korean Physical Society, vol. 55, Issue 6, Dec. 2009, pp. 2354-2360. [cited by applicant]
Leitgeb et al., “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express, vol. 11, 2003, pp. 889-894. [cited by applicant]
Marin-Palomo et al., “Microresonator-based solitons for massively parallel coherent optical communications,” Nature, vol. 546, 2017, pp. 274-279. [cited by applicant]
Matsko et al., “Optical hyperparametric oscillations in a whispering-gallery-mode resonator: Threshold and phase diffusion,” Phys. Rev., A 71, 2005. [cited by applicant]
Miller et al., “Low-loss silicon platform for broadband mid-infrared photonics,” Optica, vol. 4, Issue 7, 2017, pp. 702-712. [cited by applicant]
Miller et al., “On-chip frequency comb generation at visible wavelengths via simultaneous second- and third-order optical nonlinearities,” Opt. Express, vol. 22, 26517, 2014). [cited by applicant]
Nguyen et al., “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Research, vol. 69, Issue 22, Nov. 2009, pp. 8790-8796. [cited by applicant]
Okawachi et al., “Octave-spanning frequency comb generation in a silicon nitride chip,” Opt. Lett., vol. 36, 2011, pp. 3398-3400. [cited by applicant]
Pfeiffer et al., “Octave-spanning dissipative Kerr soliton frequency combs in Si_3N_4 microresonators,” Optica., vol. 4, 684, 2017. [cited by applicant]
Pu et al., “Efficient frequency comb generation in AlGaAs-on-insulator,” Optica., vol. 3, 823, 2016. [cited by applicant]
Savastru et al., “Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study,” J. Biomed. Opt., vol. 19, 2014, pp. 056001-056001. [cited by applicant]
Savchenkov et al., “Kerr combs with selectable central frequency,” Nat. Photonics., vol. 5 2011, pp. 293-296. [cited by applicant]
Shidlovski et al., “Superluminescent Diode Light Sources for OCT. in Optical Coherence Tomography (eds. Drexler, W. & Fujimoto, J. G.),” pp. 505-526 (Springer International Publishing, 2015). doi:10.1007/978-3-319-06419… [cited by applicant]
Smirnov et al., “Optical spectral broadening and supercontinuum generation in telecom applications,” Optical Fiber Technology, vol. 12, Issue 2, Apr. 2006, pp. 122-147. [cited by applicant]
Suh et al., “Microresonator soliton dual-comb spectroscopy,” Science, vol. 354, 2016, pp. 600-603. [cited by applicant]
Tearney et al., “Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies,” J. Am. Coll. Cardiol., vol. 59, 2012, pp. 1058-1072. [cited by applicant]
Wang et al., “Mid-infrared optical frequency combs at 2.5 μm based on crystalline microresonators,” Nat. Commun., vol. 4, 1345, 2013. [cited by applicant]
Wang, Ling et al. “Graphics processing unit-based dispersion encoded full-range frequency-domain optical coherence tomography”. Journal of Biomedical Optics, vol. 17(7), 077007, Jul. 2012, pp. 077007-1-077007-7. (Year: … [cited by applicant]
Xue et al., “Microresonator Kerr frequency combs with high conversion efficiency,” Laser Photonics Rev., 11, n/a-n/a, 2017. [cited by applicant]
Xue et al., “Mode-locked dark pulse Kerr combs in normal-dispersion microresonators,” Nat. Photonics, vol. 9, 2015, pp. 594-600. [cited by applicant]
Yao et al., “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med., vol. 49, 2017, pp. 258-269. [cited by applicant]
Gaeta et al., E2CDA: Type I: Collaborative Research: Energy efficient computing with chip-based photonics, NSF Award #: 16401088, 2016. [cited by applicant]