Systems and methods for controlling temperature gradient along a differential mobility spectrometer
A system and method are provided for controlling the temperature gradient along a differential mobility spectrometer having a differential mobility spectrometer having an inlet and an outlet, wherein the inlet is configured to receive ions transported from an ion source by a transport gas. The differential mobility spectrometer has an internal operating pressure, electrodes, and at least one voltage source for providing DC and RF voltages to the electrodes for separating ions that are transported from the inlet to the outlet. A gas port is provided near the outlet for introducing a throttle gas to control the flow rate of the transport gas through the differential mobility spectrometer and thereby adjust the ion residence time. A heater is provided for controlling the temperature of the throttle gas to minimize the temperature gradient between the inlet and outlet of the differential mobility spectrometer. A method of calibrating a DMS is also disclosed.
1 . A mass spectrometer system comprising:
a differential mobility spectrometer having an inlet and an outlet, wherein the inlet is configured to receive ions transported from an ion source by a transport gas, the differential mobility spectrometer having an internal operating pressure, electrodes, and at least one voltage source for providing DC and RF voltages to the electrodes for separating ions that are transported from the inlet to the outlet;
a gas port proximate the outlet for introducing a throttle gas to control the flow rate of the transport gas through the differential mobility spectrometer; and
a heater for controlling the temperature of the throttle gas to minimize, based on temperature of the transport gas, temperature gradient between the inlet and outlet of the differential mobility spectrometer.
2 . The mass spectrometer system of claim 1 , wherein the heater controls the temperature of throttle gas flow from the gas port to be approximately the same as the temperature of the transport gas flow at a pre-determined location in the differential mobility spectrometer.
3 . The mass spectrometer system of claim 2 , wherein the pre-determined location is at the inlet of the differential mobility spectrometer.
4 . The mass spectrometer system of claim 1 , further comprising a controller for sensing the temperature of gas flow proximate to at least one of the inlet and outlet of the differential mobility spectrometer and adjusting the temperature of the throttle gas flow to normalize temperature difference between the inlet and outlet of the differential mobility spectrometer.
5 . The mass spectrometer system of claim 4 , wherein the controller includes at least one regulator for controlling flow of said transport gas and throttle gas, and at least one heater power controller for controlling temperature of said transport gas and throttle gas.
6 . The mass spectrometer system of claim 1 , further comprising a gas line for conveying the throttle gas to the gas port and a jacket liner surrounding the gas line, and wherein the heater comprises an in-line heating element within the jacket liner.
7 . A method of operating a differential mobility spectrometer having an inlet and an outlet, comprising:
receiving ions from an ion source by a transport gas;
conveying the ions from the inlet to the outlet of the differential mobility spectrometer;
providing DC and RF electric fields within the differential mobility spectrometer for separating the ions based on mobility as they are transported from the inlet to the outlet;
introducing a throttle gas to control the flow rate of the transport gas through the differential mobility spectrometer; and
controlling the temperature of the throttle gas to minimize, based on temperature of the transport gas, temperature gradient between the inlet and outlet of the differential mobility spectrometer.
8 . The method of claim 7 , wherein the temperature of throttle gas is controlled at the outlet of the differential mobility spectrometer to be approximately the same as the temperature of the transport gas at a pre-determined location within the differential mobility spectrometer.
9 . The method of claim 8 , wherein the pre-determined location is proximate the inlet of the differential mobility spectrometer.
10 . The method of claim 7 , wherein the temperature of gas at the inlet and outlet of the differential mobility spectrometer is controlled to be in the range of 75° to 300° C.
11 . The method of claim 7 , wherein the temperature of the throttle gas is controlled to be approximately 100-200° C.
12 . The method of claim 7 , further comprising sensing the temperature of gas flow proximate to at least one of the inlet and outlet of the differential mobility spectrometer and adjusting the temperature of the throttle gas flow to normalize temperature difference between the inlet and outlet of the differential mobility spectrometer.
13 . The method of claim 7 , further comprising regulating flow of said transport gas and throttle gas.
14 . The method of claim 7 , further comprising controlling temperature of said transport gas.
15 . The mass spectrometer system of claim 1 , further comprising a curtain plate including an aperture for receiving the ions and defining a curtain chamber containing the differential mobility spectrometer, a curtain gas supply for supplying a curtain gas into the curtain chamber to provide the transport gas flow through the differential mobility spectrometer, and a curtain gas outflow out of the curtain chamber.
16 . The mass spectrometer system of claim 15 , further comprising a heat exchanger in the curtain plate for heating the curtain gas.
17 . The mass spectrometer system of claim 16 , wherein the heat exchanger is surrounded by ceramic beads through which the curtain gas flows and is heated thereby.