Compounds and compositions for treating conditions associated with STING activity
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.
1 . A compound of Formula (I):
or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein:
L A is -(L 1 ) a1 -(L 2 ) a2 (L 3 ) a3 -(L 4 ) a4 -(L 5 ) a5 -*, wherein * represents the point of attachment to Q 1 ;
a1, a2, a3, a4, and a5 are each independently 0 or 1,
provided that at +a2+a3+a4+a5≥1, and
each of L 1 , L 3 , and L 5 is independently selected from the group consisting of: —O—, —N(H)—, —N(R d )—, S(O) 0-2 , and —C(═O)—;
provided that when one or both of a2 and a4 is 0, then the combinations of L 1 , L 3 , and L 5 cannot form O—O, N—O, N—N, O—S, S—S, or N—S(O) 0 bonds, and
each of L 2 and L 4 is independently selected from the group consisting of:
straight-chain C 1-6 alkylene, straight-chain C 2-6 alkenylene, or straight-chain C 2-6 alkynylene, each of which is optionally substituted with 1-6 R b ;
C 3-10 cycloalkylene or C 3-10 cycloalkenylene, each of which is optionally substituted with 1-3 R c provided the C 3-10 cycloalkylene or C 3-10 cycloalkenylene is not directly connected to the 6-membered ring containing Y 1 , Y 2 , and Y 3 ; and
heterocyclylene or heterocycloalkenylene, each having 4-10 ring atoms wherein 1-3 ring atoms are ring heteroatoms each independently selected from the group consisting of: N, N(H), N(R d ), O, and S(O) 0-2 , wherein the heterocyclylene or heterocycloalkenylene is optionally substituted with 1-3 R c , provided that the heterocyclylene or heterocycloalkenylene is not directly connected to the 6-membered ring containing Y 1 , Y 2 , and Y 3 ;
Q 1 is —R g ;
Y 1 , Y 2 , and Y 3 are each independently selected from the group consisting of CR 1 , C(═O), N, and NW;
X 1 is NH;
X 2 is CH;
each is independently a single bond or a double bond, provided that the five-membered ring comprising X 1 and X 2 is heteroaryl, and that the six-membered ring comprising Y 1 , Y 2 , and Y 3 is aryl or heteroaryl;
further provided that L A cannot include a cyclic group directly attached to the 6-membered ring containing Y 1 , Y 2 , and Y 3 ;
each occurrence of R 1 is independently selected from the group consisting of: H; R c ; R g ; and -(L g ) bg -R g ;
each occurrence of R 2 is independently selected from the group consisting of: H; R d ; R g ; and -(L g ) bg -R g ;
R 6 is selected from the group consisting of: H; R d ; and R g ;
W is selected from the group consisting of:
H;
C 1-10 alkyl, C 2-10 alkenyl, or C 2-10 alkynyl, each of which is optionally substituted with 1-6 R a2 , wherein one or more of the internal optionally substituted methylene group can be replaced by one or more heteroatom selected from O or S, wherein when W is alkenyl or alkynyl, the heteroatom is not directly connected to the sp 2 or sp carbon;
monocyclic C 3-8 cycloalkyl or C 3-8 cycloalkenyl, each of which is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo and R c ; and
monocyclic heterocyclyl or heterocycloalkenyl of 3-8 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heterocyclyl or heterocycloalkenyl is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo and RC, provided that when W is heterocyclyl or heterocycloalkenyl, the heterocyclyl or heterocycloalkenyl is attached to the C(═O)NR 6 group via a ring carbon atom;
each occurrence of R a and R a2 is independently selected from the group consisting of: —OH; —halo; —NR e R f ; C 1-4 alkoxy; C 1-4 haloalkoxy; —C(═O)O(C 1-4 alkyl); —C(═O)(C 1-4 alkyl); —C(═O)OH; —CONR′R″; —S(O) 1-2 NR′R”; —S(O) 1-2 (C 1-4 alkyl); and cyano;
each occurrence of R b and R c is independently selected from the group consisting of: halo; cyano; C 1-10 alkyl which is optionally substituted with 1-6 independently selected R a ; C 2-6 alkenyl; C 2-6 alkynyl; C 1-4 alkoxy; C 1-4 haloalkoxy; —S(O) 1-2 (C 1-4 alkyl); —S(O)(=NH)(C 1-4 alkyl); —NR e R f ; —OH; —S(O) 1-2 NR′R″; —C 1-4 thioalkoxy; —NO 2 ; —C(═O)(C 1-10 alkyl); —C(═O)O(C 1-4 alkyl); —C(═O)OH; —C(═O)NR′R″; —NR′C(═O)(C 1-4 alkyl) and —SF 5 ;
each occurrence of R d is independently selected from the group consisting of: C 1-6 alkyl optionally substituted with 1-3 independently selected R a ; —C(O)(C 1-4 alkyl); —C(O)O(C 1-4 alkyl); —CONR′R″; —S(O) 1-2 NR′R″; —S(O) 1-2 (C 1-4 alkyl); —OH; and C 1-4 alkoxy;
each occurrence of R e and R f is independently selected from the group consisting of: H; C 1-6 alkyl optionally substituted with 1-3 substituents each independently selected from the group consisting of NR′R″, —OH, halo, C 1-4 alkoxy, and C 1-4 haloalkoxy; —C(O)(C 1-4 alkyl); —C(O)O(C 1-4 alkyl); —CONR′R″; —S(O) 1-2 NR′R″; —S(O) 1-2 (C 1-4 alkyl); —OH; and C 1-4 alkoxy;
each occurrence of R g is independently selected from the group consisting of:
C 3-12 cycloalkyl or C 3-12 cycloalkenyl, each of which is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo, R c , and R h ;
heterocyclyl or heterocycloalkenyl of 3-12 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heterocyclyl or heterocycloalkenyl is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo, R c , and R h ;
heteroaryl of 5-12 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo, R c , and R h ; and
C 6-10 aryl optionally substituted with 1-4 substituents independently selected from the group consisting of oxo, R c , and R h ;
each occurrence of R h is independently selected from the group consisting of:
C 3-12 cycloalkyl or C 3-12 cycloalkenyl, each of which is optionally substituted with 1-4 R i ;
heterocyclyl or heterocycloalkenyl of 3-12 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heterocyclyl or heterocycloalkenyl is optionally substituted with 1-4 R i ;
heteroaryl of 5-12 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl is optionally substituted with 1-4 R i ; and
C 6-10 aryl optionally substituted with 1-4 R i ;
each occurrence of R i is independently selected from the group consisting of: C 1-6 alkyl; C 1-4 haloalkyl; C 1-4 alkoxy; C 1-4 haloalkoxy; and halo;
each occurrence of L g is independently selected from the group consisting of: —O—, —NH—, —NR d , —S(O) 0-2 , C(O), and C 1-3 alkylene optionally substituted with 1-3 R a ;
each occurrence of bg is independently 1, 2, or 3; and
each occurrence of R′ and R″ is independently selected from the group consisting of: H; —OH; and C 1-4 alkyl.
2 . The compound of claim 1 , wherein a2 is 1.
3 . The compound of claim 1 , wherein L 2 is straight-chain C 1-6 alkylene, straight-chain C 2-6 alkenylene, or straight-chain C 2-6 alkynylene, each of which is optionally substituted with 1-6 R b .
4 . The compound of claim 3 , wherein L 2 is straight-chain C 1-6 alkylene, which is optionally substituted with 1-6 R b .
5 . The compound of claim 3 , wherein L 2 is straight-chain C 1-3 alkylene, which is optionally substituted with 1-3 R b .
6 . The compound of claim 1 , wherein L 2 is selected from the group consisting of:
C 3-10 cycloalkylene or C 3-10 cycloalkenylene, each of which is optionally substituted with 1-3 R c ; and
heterocyclylene or heterocycloalkenylene, each having 4-10 ring atoms wherein 1-3 ring atoms are ring heteroatoms each independently selected from the group consisting of: N, N(H), N(R d ), O, and S(O) 0-2 , wherein the heterocyclylene or heterocycloalkenylene is optionally substituted with 1-3 R c .
7 . The compound of claim 1 , wherein a1 is 1.
8 . The compound of claim 1 , wherein L 1 is selected from the group consisting of: —O—, —N(H)—, —N(R d )—, and —S—.
9 . The compound of claim 1 , wherein a1 is 0.
10 . The compound of claim 1 , wherein a3 is 1.
11 . The compound of claim 1 , wherein L 3 is selected from the group consisting of —O—, —N(H)—, —N(R d )—, and —S—.
12 . The compound of claim 1 , wherein a3 is 0.
13 . The compound of claim 1 , wherein a4 is 1.
14 . The compound of claim 1 , wherein:
a1 and a2 are each 1.
15 . The compound of claim 14 , wherein a3, a4, and a5 are each 0.
16 . The compound of claim 1 , wherein a1 is 0; a2 is 1.
17 . The compound of claim 16 , wherein a3 is 1.
18 . The compound of claim 17 , wherein L 3 is —O—.
19 . The compound of claim 16 , wherein a4 is 0; and a5 is 0.
20 . The compound of claim 16 , wherein L 2 is straight-chain C 1-6 alkylene, which is optionally substituted with 1-6 R b .
21 . The compound of claim 20 , wherein L 2 is straight-chain C 1-3 alkylene, which is optionally substituted with 1-3 R b .
22 . The compound of claim 21 , wherein a3 is 1, and L 3 is —O—.
23 . The compound of claim 22 , wherein a4 and a5 are each 0.
24 . The compound of claim 23 , wherein L A is —CH 2 CH 2 —O*.
25 . The compound of claim 1 , wherein Q 1 is selected from the group consisting of:
heteroaryl of 5-6 ring atoms, wherein 1-4 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heteroaryl is optionally substituted with 1-3 R c ; and
phenyl optionally substituted with 1-3 R c .
26 . The compound of claim 1 , wherein Q 1 is heterocyclyl or heterocycloalkenyl of 3-12 ring atoms, wherein 1-3 ring atoms are heteroatoms, each independently selected from the group consisting of N, N(H), N(R d ), O, and S(O) 0-2 , and wherein the heterocyclyl or heterocycloalkenyl is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo and R c .
27 . The compound of claim 1 , wherein Y 1 is CR i ; Y 2 is CR 1 ; and/or Y 3 is CR 1 .
28 . The compound of claim 1 , wherein Y 1 , Y 2 , and Y 3 are each CH.
29 . The compound of claim 1 , wherein R 6 is H.
30 . The compound of claim 1 , wherein W is:
(i) C 1-10 alkyl, C 2-10 alkenyl, or C 2-10 alkenyl, each of which is optionally substituted with 1-6 R a2 , wherein one or more of the internal optionally substituted methylene group can be replaced by one or more heteroatom selected from O or S, wherein when W is alkenyl or alkynyl, the heteroatom is not directly connected to the sp 2 or sp carbon.
31 . The compound of claim 1 , wherein W is:
monocyclic C 3-8 cycloalkyl or C 3-8 cycloalkenyl, each of which is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo and R c .
32 . A compound selected from the group consisting of:
101
N-(5-(((3,4-dichlorobenzyl)oxy)methyl)-1H-indol-3-
y1)acetamide
102
N-(5-(cis-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-yl)acetamide
103
N-(5-(trans-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-y1)acetamide
104
N-(5-(2-(1-(4-(trifluoromethyl)phenyl)piperidin-4-
yl)ethoxy)-1H-indol-3-yl)acetamide
105
N-(5-(2-fluoro-2-(1-(2,2,2-trifluoroethyl)piperidin-4-
yl)ethoxy)-1H-indol-3-y1)acetamide
106
N-(5-(((3-(trifluoromethyl)benzyl)oxy)methyl)-1H-indol-3-
yl)acetamide
107
2-methoxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-
3-y1)acetamide
108
N-(5-(2-methyl-2-(1-(2.2.2-trifluoroethyl)piperidin-4-
y1)propoxy)-1H-indol-3-y1)acetamide
109
N-(5-(((4-(trifluoromethyl)benzyl)oxy)methyl)-1H-indol-3-
y1)cyclobutanecarboxamide
110
N-(5-(2-((1R,5S,6s)-3-(2,2,2-trifluoroethyl)-3-
azabicyclo[3.1.0]hexan-6-yl)ethoxy)-1H-indol-3-
y1)acetamide
111
N-(5-(((4-(trifluoromethyl)benzyl)oxy)methyl)-1H-indol-3-
y1)acetamide
112
N-(5-(3-(4,4-difluoropiperidin-1-y1)-2,2-difluoropropoxy)
1H-indol-3-y1)acetamide
113
N-(5-(2-(6-(trifluoromethyl)pyridin-3-yl)ethoxy)-1H-indol-
3-y1)acetamide
114
N-(5-(2-(1-(2,2.2-trifluoroethyl)piperidin-4-y1)ethyl)-1H-
indol-3-yl)acetamide
115
N-(5-((4-(trifluoromethyl)phenoxy)methyl)-1H-indol-3-
y1)acetamide
116
N-(5-((5-(trifluoromethyl)pyridin-2-y1)oxy)-1H-indol-3-
yl)acetamide
117
2-methoxy-N-(5-(2-(1-(2,2,2-trifluoroethyl)piperidin-4-
yl)ethoxy)-1H-indol-3-yl)acetamide
118
3-hydroxy-3-methyl-N-(5-(2-(1-(2,2,2-
trifluoroethyl)piperidin-4-y1)ethoxy)-1H-indol-3-
y1)butanamide
119
N-(5-((1-(2,2,2-trifluoroethyl)piperidin-4-yl)methoxy)-1H-
indol-3-yl)acetamide
120
N-(5-(((1R,5S,6r)-3-(2,2,2-trifluoroethyl)-3-
azabicyclo[3.1.0]hexan-6-yl)methoxy)-1H-indol-3-
yl)acetamide
121
4-methoxy-N-(5-(2-(1-(2,2,2-trifluoroethyl)piperidin-4-
yl)ethoxy)-1H-indol-3-y1)butanamide
122
N-(5-(2-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethoxy)-1H-
indol-3-yl)acetamide
123
N-(5-((6-(trifluoromethyl)pyridin-3-yl)oxy)-1H-indol-3-
y1)acetamide
124
N-(5-(4-(trifluoromethyl)phenoxy)-1H-indol-3-y1)acetamide
125
N-(5-(((6-(trifluoromethyl)pyridin-3-yl)amino)methyl)-1H-
indol-3-yl)acetamide
126
N-(5-(2-((6-(trifluoromethyl)pyridin-3-y1)amino)ethyl)-1H-
indol-3-yl)acetamide
127
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)acetamide
128
N-(5-(4-(trifluoromethyl)benzyl)-1H-indol-3-yl)acetamide
129
N-(5-(2-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethoxy)-1H-
indol-3-y1)cyclobutanecarboxamide
130
N-(5-((4-(trifluoromethyl)phenoxy)methyl)-1H-indol-3-
y1)propionamide
131
N-(5-(4-(4-(trifluoromethyl)phenyl)butan-2-y1)-1H-indol-3-
yl)cyclobutanecarboxamide
132
N-(5-(3-(4-(trifluoromethyl)phenyl)propyl)-1H-indol-3-
yl)acetamide
133
N-(5-(3-methoxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-y1)cyclobutanecarboxamide
134
N-(5-(2-((5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-1H-
indol-3-y1)cyclobutanecarboxamide
135
(E)-N-(5-(3-(4-(trifluoromethyl)phenyl)prop-1-en-1-y1)-1H-
indol-3-y1)cyclobutanecarboxamide
136
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)acetamide
137
N-(5-(2-methyl-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-yl)cyclobutanecarboxamide
138
N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)propionamide
139
N-(5-(3-(4-(trifluoromethyl)phenyl)propyl)-1H-indol-3-
yl)cyclobutanecarboxamide
140
tert-butyl 4-(2-((3-(cyclobutanecarboxamido)-1H-indol-5-
yl)oxy)ethyl)piperidine-1-carboxylate
141
N-(5-(4-(trifluoromethyl)phenethyl)-1H-indol-3-
y1)cyclobutanecarboxamide
142
N-(5-(2-(6-(trifluoromethyl)pyridin-3-yl)ethoxy)-1H-indol-
3-y1)cyclobutanecarboxamide
143
(E)-N-(5-(2-ethoxyvinyl)-1H-indol-3-
y1)cyclobutanecarboxamide
144
(E)-N-(5-(4-(trifluoromethyl)styry1)-1H-indol-3-
y1)cyclobutanecarboxamide
145
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)cyclobutanecarboxamide
146
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)propionamide
147
trans-N-(5-(-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-
1H-indol-3-y1)cyclopropanecarboxamide
148
3-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)oxetane-3-carboxamide
149
1-(2,2-difluoroethyl)-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-yl)azetidine-3-carboxamide
150
(1s,3S)-3-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
151
3-fluoro-3-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
152
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-y1)tetrahydro-2H-pyran-4-carboxamide
153
3-(hydroxymethyl)-N-(5-((4-(trifluoromethyl)benzyl)oxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
154
3-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)tetrahydrofuran-3-carboxamide
155
2,2-dimethyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclopropane-1-carboxamide
156
N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)tetrahydro-2H-pyran-4-carboxamide
157
3,3-dimethyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)butanamide
158
3-(hydroxymethyl)-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
159
3-methoxy-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
160
2-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)tetrahydrofuran-2-carboxamide
161
4-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)tetrahydro-2H-pyran-4-carboxamide
162
cis-3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
163
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)oxetane-3-carboxamide
164
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)oxetane-3-carboxamide
165
3-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)oxetane-3-carboxamide
166
3-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)oxetane-3-carboxamide
167
N-(5-(2-((6-(trifluoromethyl)pyridin-3-yl)oxy)ethyl)-1H-
indol-3-y1)cyclopropanecarboxamide
168
N-(5-(2-(p-tolyloxy)ethyl)-1H-indol-3-y1)propionamide
169
N-(5-(4-(pentafluoro-16-sulfaneyl)phenethoxy)-1H-indol-3-
y1)acetamide
170
N-(5-(2-(4-(1-(2,2.2-trifluoroethyl)piperidin-4-
yl)phenoxy)ethyl)-1H-indol-3-y1)acetamide
171
N-(5-(2-(2-(2,2,2-trifluoroethyl)-2-azaspiro[3.3 ]heptan-6-
yl)ethoxy)-1H-indol-3-yl)acetamide
172
N-(5-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-y1)-1-methylcyclopropane-1-carboxamide
173
N-(6-bromo-5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)acetamide
174
N-(5-(2-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-y1)-1-methylcyclopropane-1-carboxamide
175
2-chloro-2-fluoro-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)cyclopropane-1-carboxamide
176
1-(methoxymethyl)-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclopropane-1-carboxamide
177
3-chloro-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclobutane-1-carboxamide
178
3-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)tetrahydrofuran-3-carboxamide
179
cis-3-hydroxy-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclobutane-1-carboxamide
180
3-hydroxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-
3-y1)cyclobutane-1-carboxamide
181
2,2-difluoro-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-yl)cyclopropane-1-carboxamide
182
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)
1H-indol-3-y1)cyclopropanecarboxamide
183
N-(5-(2-(6-(4,4-difluoropiperidin-1-y1)-5-fluoropyridin-3-
yl)ethoxy)-1H-indol-3-yl)cyclopropanecarboxamide
184
N-(5-(2-((2-(trifluoromethyl)pyrimidin-5-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
185
1-(trifluoromethyl)-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
186
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)pivalamide
187
2-cyano-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
188
(1S,2R)-2-cyano-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclopropane-1-carboxamide
189
3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)tetrahydrofuran-3-carboxamide
190
cis-3-hydroxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-yl)cyclobutane-1-carboxamide
191
2-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)tetrahydrofuran-2-carboxamide
192
2,2-dimethyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclopropane-1-carboxamide
193
1-cyano-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)cyclopropane-1-carboxamide
194
trans-3-methoxy-N-(5-(2-(6-(trifluoromethyl)pyridin-3-
yl)ethoxy)-1H-indol-3-y1)cyclobutane-1-carboxamide
195
1-(2,2,2-trifluoroethyl)-N-(5-(2-(6-(trifluoromethyl)pyridin-
3-y1)ethoxy)-1H-indol-3-y1)azetidine-3-carboxamide
196
N-(5-(2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)ethoxy)-1H-
indol-3-y1)acetamide
197
N-(5-(2-(4-(trifluoromethyl)-1H-pyrazol-1-yl)ethoxy)-1H-
indol-3-y1)acetamide
198
N-(5-(2-(4-(4-methyl-1-(2,2,2-trifluoroethyl)piperidin-4-
y1)phenoxy)ethyl)-1H-indol-3-y1)acetamide
199
N-(5-(2-((5-(trifluoromethyl)pyridin-2-y1)amino)ethyl)-1H-
indol-3-y1)acetamide
200
(R)-N-(5-(2-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-
1H-indol-3-y1)cyclopropanecarboxamide
201
(S)-N-(5-(2-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-
1H-indol-3-y1)cyclopropanecarboxamide
202
3,3-dimethyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-yl)butanamide
203
(1S,2S)-2-cyano-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclopropane-1-carboxamide
204
1-(methoxymethyl)-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
205
trans-3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
206
(1S,2S)-2-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
207
3-fluoro-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
208
N-(5-(2-(2-(4-methyl-1-(2,2,2-trifluoroethyl)piperidin-4-
yl)phenoxy)ethyl)-1H-indol-3-yl)acetamide
209
N-(5-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-y1)cyclopropanecarboxamide
210
1-(2,2,2-trifluoroethyl)-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)azetidine-3-
carboxamide
211
trans-3-methoxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
212
N-(5-(3-(4-(trifluoromethyl)-1H-pyrazol-1-yl)propyl)-1H-
indol-3-yl)acetamide
213
N-(4-fluoro-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)acetamide
214
N-(5-(2-(3,4-dichlorophenoxy)ethyl)-1H-indol-3-
yl)acetamide
215
N-(5-(2-((5-(trifluoromethyl)pyridin-2-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
216
2-chloro-2-fluoro-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
217
3-chloro-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
218
1-fluoro-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
219
1-(2,2,2-trifluoroethyl)-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-yl)azetidine-3-carboxamide
220
trans-3-methoxy-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclobutane-1-carboxamide
221
cis-3-methoxy-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclobutane-1-carboxamide
222
cis-3-methoxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
223
N-(6-fluoro-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)acetamide
224
N-(5-(2-(4-(4,4-difluorocyclohexyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
225
N-(5-(2-(4-(3,3-difluorocyclobutyl)phenoxy)ethyl)-1H-
indol-3-yl)acetamide
226
N-(5-(2-(4-(tetrahydro-2H-pyran-4-y1)phenoxy)ethyl)-1H-
indol-3-yl)acetamide
227
N-(5-(trans-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-y1)-1-(3,3,3-trifluoropropyl)azetidine-3-
carboxamide
228
N-(5-(2-(p-tolyloxy)ethyl)-1H-indol-3-yl)acetamide
229
N-(5-(2-(4-chlorophenoxy)ethyl)-1H-indol-3-yl)acetamide
230
N-(5-(2-(4-cyclobutylphenoxy)ethyl)-1H-indol-3-
y1)acetamide
231
N-(5-(2-(3-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)acetamide
232
N-(5-(2-((6-(trifluoromethyl)pyridin-3-y1)oxy)ethyl)-1H-
indol-3-y1)acetamide
233
N-(5-((1-(4-(trifluoromethyl)phenyl)azetidin-3-y1)oxy)-1H-
indol-3-y1)acetamide
234
3-methoxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-
3-y1)cyclobutane-1-carboxamide
235
1-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
236
3,3-dimethyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
237
4-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)tetrahydro-2H-pyran-4-carboxamide
238
3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)oxetane-3-carboxamide
239
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)tetrahydro-2H-pyran-4-carboxamide
240
N-(5-(2-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-yl)cyclopropanecarboxamide
241
3-methoxy-N-(5-((1r,3r)-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)propanamide
242
trans-3-methoxy-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
243
1-(2,2,2-trifluoroethyl)-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
244
1-(2,2,2-trifluoroethyl)-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
245
cis-3-methoxy-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
246
cis-3-methoxy-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
247
N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
y1)acetamide
248
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-pyrrolo[3,2-
blpyridin-3-yl)acetamide
249
3,3-difluoro-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-yl)cyclobutane-1-carboxamide
250
N-(7-methyl-5-(4-(trifluoromethyl)phenethoxy)-1H-
pyrrolo[3,2-b]pyridin-3-y1)acetamide
251
1-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
252
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)cyclopropanecarboxamide
253
N-(5-(2-(5-fluoro-6-(4-(2,2,2-trifluoroethyl)piperazin-1-
yl)pyridin-3-y1)ethoxy)-1H-indol-3-yl)acetamide
254
N-(5-(2-(6-(4,4-difluoropiperidin-1-y1)-5-fluoropyridin-3-
yl)ethoxy)-1H-indol-3-yl)acetamide
255
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-pyrrolo[3,2-
b]pyridin-3-yl)acetamide
256
N-(5-(2-((4-(trifluoromethyl)phenyl)thio)ethyl)-1H-indol-3-
y1)acetamide
257
N-(5-(2-(1-(5-(trifluoromethyl)pyridin-2-yl)piperidin-4-
yl)ethoxy)-1H-indol-3-y1)acetamide
258
2-methoxy-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)acetamide
259
N-(7-methyl-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
pyrrolo[3,2-b]pyridin-3-yl)acetamide
260
2-methoxy-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)acetamide
261
1-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclopropane-1-carboxamide
262
N-(5-(2-(3-phenylbicyclo[1.1.1]pentan-1-yl)ethoxy)-1H-
indol-3-yl)acetamide
263
1-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
264
N-(7-methyl-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
265
N-(5-(((4-(trifluoromethyl)phenyl)sulfonamido)methyl)-1H-
indol-3-y1)acetamide
266
N-(5-(cis-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-y1)cyclopropanecarboxamide
267
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-pyrrolo[2,3-
blpyridin-3-yl)acetamide
268
N-(5-(((1-(2,2,2-trifluoroethyl)piperidin-4-
y1)methoxy)methyl)-1H-indol-3-yl)acetamide
270
N-(7-fluoro-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
271
N-(5-(((4-(trifluoromethyl)benzyl)oxy)methyl)-1H-
pyrrolo[2,3-b]pyridin-3-yl)acetamide
272
N-(7-methyl-5-(((4-(trifluoromethyl)benzyl)oxy)methyl)-
1H-indol-3-y1)acetamide
273
2-methoxy-N-(5-((4-(trifluoromethyl)phenoxy)methyl)-1H-
indol-3-y1)acetamide
274
N-(5-((((1R,5S,6r)-3-(2,2,2-trifluoroethyl)-3-
azabicyclo[3.1.0]hexan-6-yl)methoxy)methyl)-1H-indol-3-
y1)acetamide
275
N-(5-(3-methyl-3-(1-(2,2,2-trifluoroethyl)piperidin-4-
y1)buty1)-1H-indol-3-y1)acetamide
276
N-(7-fluoro-5-(((4-(trifluoromethyl)benzyl)oxy)methyl)-
1H-indol-3-y1)acetamide
277
N-(7-fluoro-5-(2-(1-(2,2,2-trifluoroethyl)piperidin-4-
y1)ethoxy)-1H-indol-3-y1)acetamide
278
N-(5-(2-(4,4-difluoro-1-hydroxycyclohexyl)ethoxy)-1H-
indol-3-yl)acetamide
279
(R)-N-(5-(2-(1-(2,2,2-trifluoroethyl)piperidin-3-yl)ethoxy)-
1H-indol-3-y1)acetamide
280
(S)-N-(5-(2-(1-(2,2.2-trifluoroethyl)piperidin-3-yl)ethoxy)-
1H-indol-3-y1)acetamide
281
N-(7-methyl-5-(2-(1-(2,2,2-trifluoroethyl)piperidin-4-
yl)ethoxy)-1H-indol-3-yl)acetamide
282
N-(5-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-yl)acetamide
283
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)acetamide
284
N-(5-(2-hydroxy-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-y1)acetamide
285
(S)-N-(5-((1-(4-(trifluoromethyl)phenyl)propan-2-yl)oxy)-
1H-indol-3-y1)acetamide
286
(R)-N-(5-((1-(4-(trifluoromethyl)phenyl)propan-2-yl)oxy)-
1H-indol-3-y1)acetamide
287
N-(5-(2-(4-(trifluoromethyl)phenoxy)propyl)-1H-indol-3-
yl)acetamide
288
N-(5-(2-((1-(2,2,2-trifluoroethyl)piperidin-4-y1)oxy)ethyl)-
1H-indol-3-y1)acetamide
289
N-(5-((1-(4-(trifluoromethyl)phenyl)cyclopropyl)methoxy)-
1H-indol-3-y1)acetamide
290
N-(5-(2-hydroxy-5-methylbenzy1)-1H-indol-3-
yl)propionamide
291
N-(5-((p-tolyloxy)methyl)-1H-indol-3-y1)propionamide
292
N-(5-(2-((3aR,5r,6aS)-2-
methyloctahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-1H-
indol-3-yl)acetamide
293
N-(5-(2-(((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)oxy)ethyl)-1H-indol-3-y1)acetamide
294
1-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)cyclobutane-1-carboxamide
295
trans-3-methoxy-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
296
trans-3-methoxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
297
3-methoxy-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclobutane-1-carboxamide
298
1-(2-methoxyethyl)-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)azetidine-3-carboxamide
299
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-y1)-1-
(3,3,3-trifluoropropyl)azetidine-3-carboxamide
300
trans-3-methoxy-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-yl)cyclobutane-1-carboxamide
301
1-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-yl)cyclopropane-1-carboxamide
302
1-fluoro-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
303
1-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)azetidine-3-carboxamide
304
2-cyano-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
305
1-(methoxymethyl)-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
306
3-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)tetrahydrofuran-3-carboxamide
307
2,2-difluoro-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)cyclopropane-1-carboxamide
308
3-(hydroxymethyl)-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)cyclobutane-1-carboxamide
309
1-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclobutane-1-carboxamide
310
3-hydroxy-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclobutane-1-carboxamide
311
1-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
312
3-(hydroxymethyl)-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
313
N-(5-(2-((3aR,5r,6aS)-2-(2,2-
difluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-yl)acetamide
314
3,3-dimethyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)butanamide
315
1-(trifluoromethyl)-N-(5-((4-(trifluoromethyl)benzyl)oxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
316
N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
y1)pivalamide
317
N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)cyclopropanecarboxamide
318
2-chloro-2-fluoro-N-(5-((4-(trifluoromethyl)benzyl)oxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
319
1-(methoxymethyl)-N-(5-((4-(trifluoromethyl)benzyl)oxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
320
trans-3-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
321
cis-3-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
322
3-chloro-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
323
3-fluoro-3-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
324
cis-3-hydroxy-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
325
2-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)tetrahydrofuran-2-carboxamide
326
3-fluoro-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
327
3,3-dimethyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
328
4-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)tetrahydro-2H-pyran-4-carboxamide
329
3-hydroxy-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)cyclobutane-1-carboxamide
330
2,2-difluoro-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-yl)cyclopropane-1-carboxamide
331
1-fluoro-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
332
cis-2-cyano-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
333
1-(methoxymethyl)-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
334
trans-3-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
335
cis-3-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
336
3-chloro-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
337
cis-3-hydroxy-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
338
3-hydroxy-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
339
3,3-dimethyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)butanamide
340
(1S,2S)-2-cyano-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy).
1H-indol-3-y1)cyclopropane-1-carboxamide
341
(1r,3R)-3-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
342
3-chloro-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
343
3-(hydroxymethyl)-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
344
cis-3-hydroxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
345
3-methoxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
346
3,3-dimethyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)cyclobutane-1-carboxamide
347
3-hydroxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
348
3,3-dimethyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-yl)cyclobutane-1-carboxamide
349
N-(5-(2-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-
yl)ethoxy)-1H-indol-3-y1)acetamide
350
N-(4-bromo-5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)acetamide
351
2-cyano-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
352
3-methoxy-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
353
1-(trifluoromethyl)-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
354
N-(5-(cis-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-y1)pivalamide
355
2-cyano-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
356
3-fluoro-3-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
357
3-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)tetrahydrofuran-3-carboxamide
358
2-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)tetrahydrofuran-2-carboxamide
359
2.2-dimethyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
360
1-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
361
3.3-dimethyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
362
1-cyano-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclopropane-1-carboxamide
363
4-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)tetrahydro-2H-pyran-4-carboxamide
364
2,2-difluoro-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
365
N-(5-(cis-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-yl)tetrahydro-2H-pyran-4-carboxamide
366
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)-1-(trifluoromethyl)cyclopropane-1-
carboxamide
367
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)pivalamide
368
2,2-dimethyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)
1H-indol-3-y1)cyclopropane-1-carboxamide
369
1-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)cyclobutane-1-carboxamide
370
1-cyano-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
371
1-fluoro-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
372
3-methyl-N-(5-(2-(6-(trifluoromethyl)pyridin-3-y1)ethoxy)-
1H-indol-3-y1)oxetane-3-carboxamide
373
N-(5-(2-(6-(trifluoromethyl)pyridin-3-y1)ethoxy)-1H-indol-
3-y1)oxetane-3-carboxamide
374
N-(5-(2-(methyl(5-(trifluoromethyl)pyridin-2-
y1)amino)ethyl)-1H-indol-3-y1)acetamide
375
N-(4,6-difluoro-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)acetamide
376
1-methyl-N-(5-(3-(6-(trifluoromethyl)pyridin-3-
yl)cyclobutoxy)-1H-indol-3-yl)cyclopropane-1-
carboxamide
377
N-(5-(2-((1-(2,2,2-trifluoroethyl)azetidin-3-yl)oxy)ethyl)-
1H-indol-3-y1)acetamide
378
3-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)oxetane-3-carboxamide
379
1-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
380
3-fluoro-3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
381
N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
yl)oxetane-3-carboxamide
382
3-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)oxetane-3-carboxamide
383
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)oxetane-3-carboxamide
384
N-(5-(3-(4-(trifluoromethyl)-1H-pyrazol-1-y1)propyl)-1H-
indol-3-y1)cyclopropanecarboxamide
385
N-(5-(2-(1-(difluoromethyl)-1H-pyrazol-4-y1)ethoxy)-1H-
indol-3-y1)acetamide
386
N-(5-(2-((4-benzyl-3-oxo-3,4-dihydro-2H-
benzo[b][1,4]thiazin-6-yl)oxy)ethyl)-1H-indol-3-
yl)acetamide
387
1-(trifluoromethyl)-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclopropane-1-carboxamide
388
3,3-difluoro-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclobutane-1-carboxamide
389
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)pivalamide
390
2-cyano-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclobutane-1-carboxamide
391
(1S,2S)-2-cyano-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclopropane-1-carboxamide
392
trans-3-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclobutane-1-carboxamide
393
cis-3-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclobutane-1-carboxamide
394
(1S,2S)-2-methyl-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)cyclopropane-1-carboxamide
395
3-fluoro-3-methyl-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclobutane-1-carboxamide
396
2-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)tetrahydrofuran-2-carboxamide
397
2,2-dimethyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclopropane-1-carboxamide
398
1-cyano-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)cyclopropane-1-carboxamide
399
1-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclopropane-1-carboxamide
400
1-fluoro-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)cyclopropane-1-carboxamide
401
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
y1)tetrahydro-2H-pyran-4-carboxamide
402
N-(2-bromo-5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
y1)acetamide
404
2-(2-methoxyethoxy)-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-yl)acetamide
405
2-(2-methoxyethoxy)-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)acetamide
406
2-(2-methoxyethoxy)-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-yl)acetamide
407
2-(2-methoxyethoxy)-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)acetamide
408
2-(2-methoxyethoxy)-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)acetamide
409
2,2-dimethyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-yl)oxetane-3-carboxamide
410
N-(5-(2-(3,5-difluoro-4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)acetamide
411
N-(5-(2-(2-chloro-4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)acetamide
412
cis-3-acetamido-1-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
413
trans-3-acetamido-1-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
414
cis-3-hydroxy-1-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-y1)cyclobutane-1-
carboxamide
415
trans-3-hydroxy-1-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-y1)cyclobutane-1-
carboxamide
416
trans-3-(hydroxymethyl)-1-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-y1)cyclobutane-1-
carboxamide
417
cis-3-(hydroxymethyl)-1-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-y1)cyclobutane-1-
carboxamide
418
trans-4-hydroxy-1-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-y1)cyclohexane-1-
carboxamide
419
trans-4-hydroxy-1-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-yl)cyclohexane-1-
carboxamide
420
1-(hydroxymethyl)-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
421
1-(2,2-difluoroethyl)-3-methyl-N-(5-((4-
(trifluoromethyl)benzyl)oxy)-1H-indol-3-y1)azetidine-3-
carboxamide
422
1-(2-methoxyethy1)-3-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
423
(2S,3R)-2-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)oxetane-3-carboxamide
424
(2R,3R)-2-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)oxetane-3-carboxamide
425
trans-4-
hydroxy-1-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclohexane-1-carboxamide
426
cis-4-hydroxy-1-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclohexane-1-carboxamide
427
(1r,3R)-3-methoxy-1-methyl-N-(5-(2-((3aR,5r,6aS)-2-
(2,2,2-trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)ethoxy)-1H-indol-3-y1)cyclobutane-1-carboxamide
428
2.4-dimethyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-yl)oxetane-3-carboxamide
429
(R)-2-hydroxy-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)butanamide
430
(S)-2-hydroxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)butanamide
431
(R)-2-hydroxy-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-y1)butanamide
432
N-(5-((1R,3R)-2,2-dimethyl-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)acetamide
433
4,4,4-trifluoro-3-hydroxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)butanamide
434
2-(2,2,2-trifluoroethoxy)-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)acetamide
435
N-(5-(trans-3-(2-methyl-4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)acetamide
436
N-(5-((6-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-2-
y1)oxy)-1H-indol-3-yl)acetamide
437
N-(5-((7-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-2-
yl)methoxy)-1H-indol-3-y1)acetamide
438
N-(5-(2-(3-fluoro-4-(trifluoromethoxy)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
439
N-(5-(2-((5-(difluoromethyl)pyridin-3-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
440
N-(5-(2-(2-cyano-4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-yl)acetamide
441
N-(5-(2-(3-(2,2,2-trifluoroethyl)phenoxy)ethyl)-1H-indol-3-
yl)acetamide
442
N-(5-(2-(4-(2,2,2-trifluoroethyl)phenoxy)ethyl)-1H-indol-3-
yl)acetamide
443
N-(5-((1R,2R,3R)-2-methyl-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)acetamide
444
N-(5-((1-(2,2,2-trifluoroethyl)-1,4,5,6-
tetrahydrocyclopenta[c]pyrazol-5-y1)methoxy)-1H-indol-3-
y1)acetamide
445
(cis)-3-hydroxy-1-methyl-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)cyclobutane-1-
carboxamide
446
trans-3-hydroxy-1-methyl-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)cyclobutane-1-
carboxamide
447
N-(5-((2-(2,2,2-trifluoroethyl)-2,4,5,6-
tetrahydrocyclopenta[c]pyrazol-5-y1)methoxy)-1H-indol-3-
yl)acetamide
448
N-(5-((1R,2S,3R)-2-methyl-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)acetamide
449
N-(5-(2-(isoquinolin-7-yloxy)ethyl)-1H-indol-3-
y1)acetamide
450
N-(5-(2-(4-chloro-2-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
451
N-(5-(2-(4-(pyridin-4-yl)phenoxy)ethyl)-1H-indol-3-
y1)acetamide
452
N-(5-(2-(4-(2.2,2-trifluoroethoxy)phenoxy)ethyl)-1H-indol-
3-y1)acetamide
453
N-(5-(2-(3-(cyanomethyl)phenoxy)ethyl)-1H-indol-3-
y1)acetamide
454
N-(5-(2-(cis-4-(trifluoromethyl)cyclohexyl)ethoxy)-1H-
indol-3-y1)acetamide
455
N-(5-(cis-3-(6-(trifluoromethyl)pyridin-3-yl)cyclobutoxy)-
1H-indol-3-yl)acetamide
456
N-(5-(2-(trans-4-(trifluoromethyl)cyclohexyl)ethoxy)-1H-
indol-3-y1)acetamide
457
N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethyl)-1H-
indol-3-y1)acetamide
458
N-(5-(2-(bicyclo[1.1.1]pentan-1-yl)ethoxy)-1H-indol-3-
y1)acetamide
459
N-(5-(trans-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-y1)azetidine-3-carboxamide
460
4-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)piperidine-4-carboxamide
461
N-(5-(2-(4-(2-methoxyethyl)phenoxy)ethyl)-1H-indol-3-
yl)acetamide
462
N-(5-(2-(4-cyanophenoxy)ethyl)-1H-indol-3-y1)acetamide
463
N-(5-(2-((2-cyclopropylpyridin-4-y1)oxy)ethyl)-1H-indol-3-
yl)acetamide
464
1-methyl-N-(5-(3-(5-(trifluoromethyl)pyridin-2-y1)propyl)-
1H-indol-3-y1)cyclopropane-1-carboxamide
465
4-(trifluoromethyl)-N-(5-(trans-3-(6-
(trifluoromethyl)pyridin-3-y1)cyclobutoxy)-1H-indol-3-
y1)benzamide
466
tert-butyl 3-((5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)carbamoyl)azetidine-1-carboxylate
467
2-cyano-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
468
1-(methoxymethyl)-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclopropane-1-carboxamide
469
3-fluoro-3-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
470
N-(5-(2-(4-fluoro-3-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
471
N-(5-(2-((6-(trifluoromethoxy)pyridin-3-y1)oxy)ethyl)-1H-
indol-3-y1)acetamide
472
N-(5-((4-(trifluoromethyl)cyclohexyl)methoxy)-1H-indol-3-
y1)acetamide
473
N-(5-((5-(trifluoromethyl)-2,3-dihydro-1H-inden-2-yl)oxy)-
1H-indol-3-yl)acetamide
474
N-(5-(2-(3-(trifluoromethyl)bicyclo[ 1.1. 1]pentan-1-
yl)ethoxy)-1H-indol-3-yl)acetamide
475
N-(5-(2-(4-(2-methylthiazol-4-yl)phenoxy)ethyl)-1H-indol-
3-y1)acetamide
476
N-(5-(2-(3-chloro-5-cyanophenoxy)ethyl)-1H-indol-3-
yl)acetamide
477
N-(5-(2-((8-(trifluoromethoxy)quinolin-3-y1)oxy)ethyl)-1H-
indol-3-y1)acetamide
478
N-(5-(2-(5-(2,2,2-trifluoroethyl)-5-azaspiro[2.4]heptan-7-
yl)ethoxy)-1H-indol-3-y1)acetamide
479
3-methyl-N-(5-(((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)methoxy)-
1H-indol-3-y1)oxetane-3-carboxamide
480
N-(5-(2-((6-(trifluoromethoxy)quinolin-3-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
481
N-(5-(2-((5-(trifluoromethyl)pyridin-3-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
482
N-(5-((trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)methyl)-1H-indol-3-
yl)acetamide
483
1-(2,2-difluoroethyl)-3-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
484
N-(5-(2-(4-methyl-2-(trifluoromethyl)thiazol-5-yl)ethoxy)-
1H-indol-3-y1)acetamide
485
3-methyl-N-(5-(((1R,3s,5S)-8-(2,2,2-trifluoroethyl)-8-
azabicyclo[3.2.1 ]octan-3-yl)methoxy)-1H-indol-3-
yl)oxetane-3-carboxamide
486
2-(2-methoxyethoxy)-N-(5-((trans)-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)acetamide
487
2-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)tetrahydrofuran-2-carboxamide
488
4-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)tetrahydro-2H-pyran-4-carboxamide
489
1-fluoro-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
490
N-(5-(2-((5,6,7,8-tetrahydronaphthalen-2-y1)oxy)ethyl)-1H-
indol-3-yl)acetamide
491
N-(5-(2-((2-(difluoromethoxy)pyridin-4-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
492
N-(5-(((2-(2,2,2-trifluoroethyl)-2-azabicyclo[2.1.1 ]hexan-1-
yl)methoxy)methyl)-1H-indol-3-y1)acetamide
493
N-(5-(trans-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-yl)tetrahydro-2H-pyran-4-carboxamide
494
N-(5-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)oxy)-
1H-indol-3-y1)acetamide
495
N-(5-((4-(trifluoromethyl)phenyl)ethynyl)-1H-indol-3-
y1)acetamide
496
2,2,4,4-tetramethyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-
1H-indol-3-y1)oxetane-3-carboxamide
497
N-(5-(1-(4-(trifluoromethyl)phenyl)ethoxy)-1H-indol-3-
y1)acetamide
498
N-(5-(2-(1-(2,2,2-trifluoroethyl)piperidin-3-yl)ethoxy)-1H-
indol-3-y1)cyclopropanecarboxamide
499
N-(5-(2-((2-(1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)propan-
2-y1)oxy)ethyl)-1H-indol-3-y1)acetamide
500
N-(5-((cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)methyl)-1H-indol-3-
y1)acetamide
501
N-(5-(2-(trans-4-hydroxy-4-
(trifluoromethyl)cyclohexyl)ethoxy)-1H-indol-3-
yl)acetamide
504
(1r,4R)-4-hydroxy-1-methyl-N-(5-(2-((3aR,5r,6aS)-2-
(2,2,2-trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)ethoxy)-1H-indol-3-yl)cyclohexane-1-carboxamide
505
(1s,4S)-4-hydroxy-1-methyl-N-(5-(2-((3aR,5r,6aS)-2-
(2,2,2-trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)ethoxy)-1H-indol-3-yl)cyclohexane-1-carboxamide
506
N-(5-(2-(methylamino)-3-(4-
(trifluoromethyl)phenyl)propyl)-1H-indol-3-yl)acetamide
507
N-(5-((3-(4-(trifluoromethyl)phenyl)tetrahydrofuran-3-
yl)methy1)-1H-indol-3-y1)acetamide
508
N-(5-(2-(3-(4-(trifluoromethyl)phenyl)oxetan-3-yl)ethyl)-
1H-indol-3-y1)acetamide
509
(2S,3R)-2-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-y1)oxetane-3-carboxamide
510
(2R,3R)-2-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)oxetane-3-carboxamide
511
(1s,3S)-3-(hydroxymethyl)-1-methyl-N-(5-(2-
((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)cyclobutane-1-carboxamide
512
(1r,3R)-3-(hydroxymethyl)-1-methyl-N-(5-(2-
((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
513
(1s,3S)-3-hydroxy-1-methyl-N-(5-(2-((3aR,5r,6aS)-2-
(2,2,2-trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)ethoxy)-1H-indol-3-yl)cyclobutane-1-carboxamide
514
(1r,3R)-3-hydroxy-1-methyl-N-(5-(2-((3aR,5r,6aS)-2-
(2,2,2-trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)ethoxy)-1H-indol-3-y1)cyclobutane-1-carboxamide
515
(1s,3S)-3-methoxy-1-methyl-N-(5-(2-((3aR,5r,6aS)-2-
(2,2,2-trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-
yl)ethoxy)-1H-indol-3-yl)cyclobutane-1-carboxamide
516
N-(1-(3-acetamido-1H-indol-5-y1)-3-(4-
(trifluoromethyl)phenyl)propan-2-yl)acetamide
517
N-(5-(2-amino-3-(4-(trifluoromethyl)phenyl)propyl)-1H-
indol-3-y1)acetamide
518
N-(5-(trans-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-yl)oxetane-3-carboxamide
519
3-hydroxy-3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-
1H-indol-3-y1)butanamide
520
4-methoxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-yl)butanamide
521
(S)-2-hydroxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)butanamide
522
(R)-2-hydroxy-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)butanamide
523
-
3-hydroxy-3-methyl-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-yl)butanamide
525
2,4-dimethyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-
indol-3-yl)oxetane-3-carboxamide
526
N-(5-(2-(quinolin-6-yloxy)ethyl)-1H-indol-3-y1)acetamide
527
methyl 3-(3-acetamido-1H-indol-5-y1)-2-(4-
(trifluoromethyl)benzyl)propanoate
528
4-methyl-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-
3-y1)piperidine-4-carboxamide
529
4-methyl-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)piperidine-4-carboxamide
530
trans-3-(hydroxymethyl)-1-methyl-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)cyclobutane-1-
carboxamide
531
cis-3-(hydroxymethyl)-1-methyl-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-y1)cyclobutane-1-
carboxamide
532
3-(3-acetamido-1H-indol-5-y1)-2-(4-
(trifluoromethyl)benzyl)propanoic acid
533
cis-3-(hydroxymethyl)-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)cyclobutane-1-
carboxamide
534
0
trans-3-(hydroxymethyl)-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)cyclobutane-1-
carboxamide
536
N-(5-(2-(3-(1-(dimethylamino)ethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
537
N-(5-(cis-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-
indol-3-y1)azetidine-3-carboxamide
538
N-(5-(1-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)propan-2-
y1)-1H-indol-3-y1)acetamide
539
N-(5-(3-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)propyl)-
1H-indol-3-y1)acetamide
540
N-(5-(2-hydroxy-3-(5-(trifluoromethyl)pyridin-2-
yl)propyl)-1H-indol-3-y1)-1-methylcyclopropane-1-
carboxamide
541
N-(5-(2-((2-(trifluoromethyl)pyridin-3-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
542
3-methyl-N-(5-(((3aR,5s,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)methoxy)-
1H-indol-3-y1)oxetane-3-carboxamide
543
N-(5-(2-(3-bromo-4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
544
N-(5-(2-(2-bromo-4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
545
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)acetamide-2-13C-2,2,2-d3
546
N-(4-bromo-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
547
N-(5-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)-1H-indol-
3-yl)acetamide
548
N-(5-(2-(2-allylphenoxy)ethyl)-1H-indol-3-y1)acetamide
549
N-(5-(2-(4-(3-oxobutyl)phenoxy)ethyl)-1H-indol-3-
y1)acetamide
550
cis-3-(hydroxymethyl)-N-(5-(cis-3-(6-
(trifluoromethyl)pyridin-3-yl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
551
trans-3-(hydroxymethyl)-N-(5-(cis-3-(6-
(trifluoromethyl)pyridin-3-yl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
552
cis-3-(hydroxymethyl)-N-(5-(trans-3-(6-
(trifluoromethyl)pyridin-3-yl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
553
trans-3-(hydroxymethyl)-N-(5-(trans-3-(6-
(trifluoromethyl)pyridin-3-y1)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
554
3-chloro-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
555
N-(5-(2-((8-(trifluoromethyl)quinolin-3-y1)oxy)ethyl)-1H-
indol-3-yl)acetamide
556
N-(5-(2-((6-chloro-2-methylpyridin-3-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
557
N-(5-(2-((6-chloro-5-methylpyridin-3-yl)oxy)ethyl)-1H-
indol-3-y1)acetamide
558
N-(5-(2-phenoxyethyl)-1H-indol-3-yl)acetamide
559
N-(5-(2-((2-chloro-6-(trifluoromethyl)pyridin-4-
y1)oxy)ethyl)-1H-indol-3-y1)acetamide
560
N-(5-(2-((5-chloroquinolin-3-yl)oxy)ethyl)-1H-indol-3-
y1)acetamide
561
1-(2,2-difluoroethyl)-3-methyl-N-(5-(4-
(trifluoromethyl)phenethoxy)-1H-indol-3-yl)azetidine-3-
carboxamide
562
(1s,2s)-2-cyano-N-(5-((trans)-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclopropane-1-carboxamide
563
2,2-dimethyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
564
1-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
565
1-cyano-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
567
3-methyl-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
568
tert-butyl 3-methyl-3-((5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)carbamoyl)azetidine-1-carboxylate
569
3-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-
yl)azetidine-3-carboxamide
570
tert-butyl 3-methyl-3-((5-(4-(trifluoromethyl)phenethoxy
1H-indol-3-y1)carbamoyl)azetidine-1-carboxylate
571
2-chloro-2-fluoro-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
572
3-methoxy-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
573
3-hydroxy-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
574
2,2-difluoro-N-(5-(trans-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
575
2-chloro-2-fluoro-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclopropane-1-carboxamide
576
3-fluoro-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
yl)cyclobutane-1-carboxamide
577
2-chloro-2-fluoro-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclopropane-1-carboxamide
578
N-(7-bromo-5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)acetamide
579
1-methyl-N-(5-(cis-3-(6-(trifluoromethyl)pyridin-3-
yl)cyclobutoxy)-1H-indol-3-yl)cyclopropane-1-
carboxamide
580
1-methyl-N-(5-(cis-3-(6-(trifluoromethyl)pyridin-3-
yl)cyclobutoxy)-1H-indol-3-y1)cyclopropane-1-
carboxamide
581
N-(5-(2-(pyridin-3-yloxy)ethyl)-1H-indol-3-yl)acetamide
582
(1S,2R)-2-cyano-N-(5-(2-(4-
(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclopropane-1-carboxamide
584
3,3-difluoro-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-y1)cyclobutane-1-carboxamide
585
(1S,2S)-2-cyano-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-
indol-3-yl)cyclopropane-1-carboxamide
586
1-cyano-N-(5-((4-(trifluoromethyl)benzyl)oxy)-1H-indol-3-
y1)cyclopropane-1-carboxamide
587
3,3-difluoro-N-(5-(cis-3-(4-
(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-
y1)cyclobutane-1-carboxamide
588
3,3-difluoro-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-yl)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
589
3-fluoro-N-(5-(2-((3aR,5r,6aS)-2-(2,2,2-
trifluoroethyl)octahydrocyclopenta[c]pyrrol-5-y1)ethoxy)-
1H-indol-3-y1)cyclobutane-1-carboxamide
590
1-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)azetidine-3-carboxamide
591
3,3-dimethyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)butanamide
592
N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-indol-3-
yl)cyclopropanecarboxamide
593
3-fluoro-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)cyclobutane-1-carboxamide
594
4-methyl-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-1H-
indol-3-y1)tetrahydro-2H-pyran-4-carboxamide
595
2,2-difluoro-N-(5-(2-(4-(trifluoromethyl)phenoxy)ethyl)-
1H-indol-3-y1)cyclopropane-1-carboxamide
596
or a pharmaceutically acceptable salt thereof.
33 . The compound of claim 1 , wherein L 1 is —O—.
34 . The compound of claim 1 , wherein L 3 is —O—.
35 . The compound of claim 1 , wherein:
a1 and a2 are each 1;
L 1 is —O—, —N(H)—, or —N(R d )—; and
L 2 is selected from the group consisting of:
straight-chain CI-3 alkylene, which is optionally substituted with 1-3 R b ;
C 3-8 cycloalkylene, which is optionally substituted with 1-3 R c ; and
heterocyclylene having 4-8 ring atoms wherein 1-3 ring atoms are ring heteroatoms each independently selected from the group consisting of: N, N(H), N(R d ), O, and S(O) 0-2 , wherein the heterocyclylene is optionally substituted with 1-3 R C .
36 . The compound of claim 35 , wherein a3, a4, and a5 are each 0.
37 . The compound of claim 36 , wherein L A is
38 . The compound of claim 1 , wherein:
a1 and a2 are each 1;
L 1 is —O—; and
L 2 is straight-chain C 1-3 alkylene, which is optionally substituted with 1-3 R b .
39 . The compound of claim 38 , wherein a3, a4, and a5 are each 0.
40 . The compound of claim 39 , wherein L A is —O—CH 2 CH 2 —*.
41 . The compound of claim 1 , wherein W is C 1-10 alkyl, which is optionally substituted with 1-6 R a2 .
42 . The compound of claim 1 , wherein W is monocyclic C 3-8 cycloalkyl, which is optionally substituted with 1-4 substituents independently selected from the group consisting of oxo and R c , optionally C 1-10 alkyl, which is optionally substituted with 1-6 R a2 ; optionally C 1-4 alkyl, which is optionally substituted with 1-6 R a2 .
43 . A compound of the following structure:
trans-3-hydroxy-1-methyl-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-yl) cyclobutane-1-carboxamide.
44 . A compound of the following structure:
N-(5-(trans-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-yl)acetamide.
45 . A compound of the following structure:
N-(5-((1R,2S,3R)-2-methyl-3-(4-(trifluoromethyl)phenyl)cyclobutoxy)-1H-indol-3-yl)acetamide.
46 . A compound of the following structure:
N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-yl)acetamide.
47 . A compound of the following structure:
1-(methoxymethyl)-N-(5-(4-(trifluoromethyl)phenethoxy)-1H-indol-3-yl) cyclopropane-1-carboxamide.
48 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.
49 . A method for inhibiting STING activity, the method comprising contacting STING with the compound of claim 1 or a pharmaceutically acceptable salt thereof.
50 . A method of inducing an immune response in a subject in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.
51 . A method of treatment of a disease, disorder, or condition associated with STING in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable salt thereof.
52 . A combination comprising a compounds defined in claim 1 or a pharmaceutically acceptable salt or tautomer thereof, and one or more therapeutically active agents.
53 . A method for inhibiting STING activity, the method comprising contacting STING with the compound of claim 43 .
54 . A method of treatment of a disease, disorder, or condition associated with STING in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 51 .
55 . The method of claim 54 , wherein the disease, disorder, or condition associated with STING is selected from the group consisting of type I interferonopathies, Aicardi-Goutières Syndrome (AGS), systemic lupus erythematosus, and rheumatoid arthritis.
56 . The method of claim 54 , wherein the disease, disorder, or condition associated with STING is systemic lupus erythematosus.
57 . The method of claim 54 , wherein the disease, disorder, or condition associated with STING is amyotrophic lateral sclerosis.
58 . The method of claim 54 , wherein the disease, disorder, or condition associated with STING is Parkinson's disease.
59 . A method for inhibiting STING activity, the method comprising contacting STING with the compound of claim 44 .
60 . A method of treatment of a disease, disorder, or condition associated with STING in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 44 .
61 . The method of claim 60 , wherein the disease, disorder, or condition associated with STING is selected from the group consisting of type I interferonopathies, Aicardi-Goutières Syndrome (AGS), systemic lupus erythematosus, and rheumatoid arthritis.
62 . The method of claim 60 , wherein the disease, disorder, or condition associated with STING is systemic lupus erythematosus.
63 . The method of claim 60 , wherein the disease, disorder, or condition associated with STING is amyotrophic lateral sclerosis.
64 . The method of claim 60 , wherein the disease, disorder, or condition associated with STING is Parkinson's disease.
65 . A method for inhibiting STING activity, the method comprising contacting STING with the compound of claim 45 .
66 . A method of treatment of a disease, disorder, or condition associated with STING in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 45 .
67 . The method of claim 66 , wherein the disease, disorder, or condition associated with STING is selected from the group consisting of type I interferonopathies, Aicardi-Goutières Syndrome (AGS), systemic lupus erythematosus, and rheumatoid arthritis.
68 . The method of claim 66 , wherein the disease, disorder, or condition associated with STING is systemic lupus erythematosus.
69 . The method of claim 66 , wherein the disease, disorder, or condition associated with STING is amyotrophic lateral sclerosis.
70 . The method of claim 66 , wherein the disease, disorder, or condition associated with STING is Parkinson's disease.
71 . A method for inhibiting STING activity, the method comprising contacting STING with the compound of claim 46 .
72 . A method of treatment of a disease, disorder, or condition associated with STING in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 46 .
73 . The method of claim 72 , wherein the disease, disorder, or condition associated with STING is selected from the group consisting of type I interferonopathies, Aicardi-Goutières Syndrome (AGS), systemic lupus erythematosus, and rheumatoid arthritis.
74 . The method of claim 72 , wherein the disease, disorder, or condition associated with STING is systemic lupus erythematosus.
75 . The method of claim 72 , wherein the disease, disorder, or condition associated with STING is amyotrophic lateral sclerosis.
76 . The method of claim 72 , wherein the disease, disorder, or condition associated with STING is Parkinson's disease.
77 . A method for inhibiting STING activity, the method comprising contacting STING with the compound of claim 32 or a pharmaceutically acceptable salt thereof.
78 . A method of treatment of a disease, disorder, or condition associated with STING in need thereof, the method comprising administering to the subject an effective amount of the compound of claim 32 or a pharmaceutically acceptable salt thereof.
79 . The method of claim 78 , wherein the disease, disorder, or condition associated with STING is selected from the group consisting of type I interferonopathies, Aicardi-Goutières Syndrome (AGS), systemic lupus erythematosus, and rheumatoid arthritis.
80 . The method of claim 78 , wherein the disease, disorder, or condition associated with STING is systemic lupus erythematosus.
81 . The method of claim 78 , wherein the disease, disorder, or condition associated with STING is amyotrophic lateral sclerosis.
82 . The method of claim 78 , wherein the disease, disorder, or condition associated with STING is Parkinson's disease.
83 . The method of claim 51 , wherein the disease, disorder, or condition associated with STING is selected from the group consisting of type I interferonopathies, Aicardi-Goutières Syndrome (AGS), systemic lupus erythematosus, and rheumatoid arthritis.
84 . The method of claim 51 , wherein the disease, disorder, or condition associated with STING is systemic lupus erythematosus.
85 . The method of claim 51 , wherein the disease, disorder, or condition associated with STING is amyotrophic lateral sclerosis.
86 . The method of claim 51 , wherein the disease, disorder, or condition associated with STING is Parkinson's disease.