Granted Patent
B2
US 12,503,482 · App. 17/421,312 · Granted Dec 23, 2025
Compositions and methods for trehalose phospholipids
Inventors:
Ildiko Van Rhijn (Amsterdam, NL); Adriaan J. Minnaard (Groningen, NL); D. Branch Moody (W. Roxbury, MA); Tan-Yun Cheng (Ashland, MA); Jeffrey Buter (Groningen, NL)
C07H11/04A61K39/0002A61K39/002A61K39/02A61K39/39A61K45/06C07K16/44C12Q1/10G01N33/92A61K2039/55566G01N2405/06
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Abstract
Provided herein are compositions of trehalose phospholipids and uses thereof, e.g., compounds and compositions comprising 6,6′-diphosphatidyltrehalose (diPT) and analogs thereof with modifications of the diPT chemical scaffold, that bind and agonize Mincle, and the use thereof as adjuvants.
Claims (11)
1 . A compound of Formula (IV)
2 . A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier.
3 . An adjuvant comprising an effective amount of the pharmaceutical composition of claim 2 .
4 . A composition comprising a compound of Formula (I):
wherein R 1 is a saturated or unsaturated fatty acid alkyl and R 2 is a saturated or unsaturated fatty acid alkyl, a pharmaceutically acceptable carrier, and an antigen.
5 . The composition of claim 4 , wherein the antigen is a virus antigen, a bacterium antigen, a parasite or protozoa antigen, or a fungus antigen.
6 . The composition of claim 4 , wherein the compound is a compound of Formula (III)
7 . The composition of claim 4 , wherein the compound is a compound of Formula (IV)
8 . The composition of claim 4 , wherein the compound is a compound of Formula (V)
9 . A method of provoking an immune response to an antigen in a subject, the method comprising administering to the subject an effective amount of the composition of claim 4 .
10 . The method of claim 9 , wherein the composition is administered subcutaneously.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 20, 2022
From: RHIJN, ILDIKO VAN; MOODY, D. BRANCH
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 058715/0382 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 18, 2022
From: MINNAARD, ADRIAAN J.
To: RIJKSUNIVERSITEIT GRONINGEN
Reel/Frame 058677/0361 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 10, 2021
From: BUTER, JEFFREY
To: RIJKSUNIVERSITEIT GRONINGEN
Reel/Frame 058067/0506 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 10, 2021
From: CHENG, TAN-YUN
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 058067/0589 →
Continuity (2)
Provisional Application
62789651
· Jan 8, 2019
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