Granted Patent B2

US 12,505,906 · App. 17/637,950 · Granted Dec 23, 2025

Inventors: Jeffrey Sterling Andrews (Carmel, IN); Xuanyao He (Belmont, MA); Jie Xue (Zionsville, IN)

Assignee: Eli Lilly and Company

G16H20/17G16H40/67

Abstract

Claims (41)

1 . A method for treating diabetes in a patient in need thereof, the method comprising:

accessing data indicative of an injection event group comprising one or more injection events associated with one or more medication delivery devices, wherein each of the one or more medication delivery devices comprises:

a dose adjustment mechanism that allows a user to adjust a dose amount for an injection of insulin of the medication delivery device;

a reservoir sized sufficiently to hold medication for a plurality of doses of insulin;

one or more sensors to detect an amount of dose dispensed for each injection; and

a wireless communication unit that communicates amount of dose dispensed and time dispensed;

determining whether the injection event group is associated with a medication delivery device change;

upon determining the injection event group is not associated with the medication delivery device change, analyzing the injection event group based on a first dose detection algorithm to determine a dose administered to a user;

upon determining the injection event group is associated with the medication delivery device change, analyzing the injection event group based on a second dose detection algorithm to determine the dose administered to the user, wherein the second dose detection algorithm comprises, upon determining that a change time associated with the medication delivery device is later than a time associated with at least one injection event in the injection event group and earlier than another time associated with at least one other injection event in the injection event group:

determining a first sub-injection event group comprising each injection event in the injection event group associated with a time that occurred before the change time,

determining a first latest injection event in the first sub-injection event group, wherein the first latest injection event occurred later in time than any other injection event in the first sub-injection event group;

determining a second sub-injection event group comprising each injection event in the injection event group associated with a time that occurred after the change time,

determining a second latest injection event in the second sub-injection event group, wherein the second latest injection event occurred later in time than any other injection event in the second sub-injection event group; and

determining the dose based on a sum of the first latest injection event in the first sub-injection event group and the second latest injection event in the second sub-injection event group, wherein any remaining injection events in the first sub-injection event group and any remaining injection events in the second sub-injection event group are designated priming injection events;

calculating an amount of insulin-on-board based on the determined dose; and

calculating and administering a bolus of insulin based on the calculated amount of insulin-on-board.

2 . The method of claim 1 , wherein:

the one or more medication delivery devices comprises a previous medication delivery device and a new medication delivery device; and

determining whether the injection event group is associated with the medication delivery device change comprises determining whether the user switched from using the previous medication delivery device to using the new medication delivery device within a predetermined time window of the injection event group.

3 . The method of claim 1 , wherein:

the one or more medication delivery devices comprises one medication delivery device; and

determining whether the injection event group is associated with the medication delivery device change comprises determining whether there is a change of a replaceable medication cartridge of the one medication delivery device within a predetermined time window of the injection event group.

4 . The method of claim 1 , wherein analyzing the injection event group based on the first dose detection algorithm comprises:

determining a number of injection events in the injection event group is greater than two; and

determining the dose is equal to an injected amount associated with a latest injection event of the injection event group, wherein the latest injection event occurred later in time than any other injection event in the injection event group.

5 . The method of claim 4 , wherein the latest injection event is designated a true injection event, and all other injection events in the injection event group are each designated priming injection events.

6 . The method of claim 1 , wherein analyzing the injection event group based on the first dose detection algorithm comprises:

determining a number of injection events in the injection event group is equal to two, wherein the injection event group comprises:

a first injection event associated with a first time; and

a second injection event associated with a second time that is later than the first time; and

determining whether a first injection amount associated with the first injection event is greater than a second injection amount associated with the second injection event.

7 . The method of claim 6 , further comprising, upon determining the first injection event is greater than the second injection event, determining the dose based on a sum of the first injection amount and the second injection amount.

8 . The method of claim 6 , further comprising, upon determining the first injection event is not greater than the second injection event, determining the dose is equal to the second injection amount.

9 . The method of claim 8 , wherein the first injection event is designated a priming injection event.

10 . The method of claim 1 , wherein analyzing the injection event group based on the second dose detection algorithm comprises determining whether a change time associated with the medication delivery device change is (i) later than each time associated with each injection event in the injection event group or earlier than each time associated with each injection event in the injection event group, or (ii) later than a time associated with at least one injection event in the injection event group and earlier than another time associated with at least one other injection event in the injection event group.

11 . The method of claim 10 , further comprising, upon determining the change time is later than each time associated with each injection event in the injection event group, determining the dose is equal to an injected amount associated with a latest injection event of the injection event group, wherein the latest injection event occurred later in time than any other injection event in the injection event group.

12 . The method of claim 11 , wherein remaining injection events are designated priming injection events.

13 . The method of claim 1 , further comprising determining the injection event group.

14 . The method of claim 13 , wherein:

determining the injection event group comprises determining the plurality of injection events meet a predetermined criterion; and

determining the plurality of injection events meet a predetermined criterion comprises determining, for each injection event of the plurality of injection events, a time associated with the injection event is within a predetermined time period of a previous injection event in the plurality of injection events.

Assignments (1)

Continuity (2)

References Cited (24)