IP Library Granted Patent US 12,507,948
Granted Patent B2
US 12,507,948 · App. 18/301,612 · Granted Dec 30, 2025

System and method for attentional multimodal pain estimation

Inventors: Md Sirajus Salekin (Woodbridge, VA); Ghadh Alzamzmi (Rockville, MD); Dmitry Goldgof (Lutz, FL); Yu Sun (Tampa, FL); Thao Ho (Riverview, FL); Peter Randolph Mouton (Gulfport, FL)
Assignee: University of South Florida
A61B5/4824A61B5/0064A61B5/7264A61B7/04G06T7/0014A61B2503/045G06T2207/10016G06T2207/20081G06T2207/30004
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Quick Facts
Patent No.
US 12,507,948
App. No.
18/301,612
Granted
Dec 30, 2025
Kind
B2
Abstract

A computer-based system and method for generating a pain score of a subject using one or more sensory signals extracted from an AV signal of the subject. The AV signal may comprise one or more sensory signals including a face sensory signal, a body sensory signal and an audio sensory and wherein one or more of the sensory signals is missing from the AV signal.

Claims (43)

1 . A method for generating a pain score for a subject, the method comprising:

receiving an audio/visual (AV) signal of a subject;

extracting one or more sensory signals from the AV signal, wherein the one or more sensory signals are selected from a face sensory signal, a body sensory signal and an audio sensory signal and wherein one or more of the sensory signals is missing from the AV signal;

reconstructing the one or more missing sensory signals from one or more of the sensory signals present in the AV signal to generate one or more reconstructed sensory signals; and

performing attentional fusion to generate a pain score for the subject from the one or more sensory signals extracted from the AV signal and the one or more reconstructed sensory signals, wherein performing attentional fusion comprises generating attentive features for the one or more sensory signals extracted from the AV signal and the one or more reconstructed sensory signals and concatenating the generated attentive features to generate the pain score.

2 . The method of claim 1 , wherein extracting the one or more sensory signals from the AV signal further comprises:

training a multimodal autoencoder to extract spatio-temporal features from AV signals under different missing sensory signal conditions;

extracting spatio-temporal features from the one or more sensory signals of the AV signal using the trained multimodal autoencoder; and

generating a spatio-temporal latent space from the extracted spatio-temporal features using the trained multimodal autoencoder.

3 . The method of claim 2 , wherein reconstructing the one or more missing sensory signals to generate one or more reconstructed sensory signals further comprises:

generating a joint probability latent space from the spatio-temporal latent space, wherein the joint probability latent space comprises latent features; and

reconstructing the one or more missing sensory signals from the joint probability latent space.

4 . The method of claim 1 , wherein the pain score comprises an intensity estimation.

5 . The method of claim 1 , further comprising, recording, with an audio/video (AV) recorder, facial expressions, body movements, and sounds of the subject, wherein said AV recorder comprises a video camera for recording video of the facial expressions and body movements and a microphone for recording sounds of the subject to generate the AV signal of the subject.

6 . A system for estimating pain that may be experienced by a subject, the system comprising:

an audio/video (AV) recorder comprising a video camera for recording video of the facial expressions and body movements of a subject and a microphone for recording sounds of a subject to generate an AV signal of the subject,

a processor running a machine learning algorithm for,

extracting one or more sensory signals from the AV signal, wherein the one or more sensory signals are selected from a face sensory signal, a body sensory signal and an audio sensory signal and wherein one or more of the sensory signals is missing from the AV signal;

reconstructing the one or more missing sensory signals from one or more of the sensory signals present in the AV signal to generate one or more reconstructed sensory signals; and

performing attentional fusion to generate a pain score for the subject from the one or more sensory signals extracted from the AV signal and the one or more reconstructed sensory signals, wherein performing attentional fusion comprises generating attentive features for the one or more sensory signals extracted from the AV signal and the one or more reconstructed sensory signals and concatenating the generated attentive features to generate the pain score.

7 . The system of claim 6 , wherein extracting the one or more sensory signals from the AV signal further comprises:

training a multimodal autoencoder to extract spatio-temporal features from AV signals under different missing sensory signal conditions;

extracting spatio-temporal features from the one or more sensory signals of the AV signal using the trained multimodal autoencoder; and

generating a spatio-temporal latent space from the extracted spatio-temporal features using the trained multimodal autoencoder.

8 . The system of claim 7 , wherein reconstructing the one or more missing sensory signals to generate one or more reconstructed sensory signals further comprises:

generating a joint probability latent space from the spatio-temporal latent space, wherein the joint probability latent space comprises latent features; and

reconstructing the one or more missing sensory signals from the joint probability latent space.

9 . The system of claim 6 , wherein the pain score comprises an intensity estimation.

10 . The system of claim 6 further comprising an output device for outputting the pain score.

11 . A non-transitory computer-readable medium storing a set of instructions configured for being executed by at least one processor for performing a method for generating a pain score for a subject, the method comprising:

receiving an audio/visual (AV) signal of a subject;

extracting one or more sensory signals from the AV signal, wherein the one or more sensory signals are selected from a face sensory signal, a body sensory signal and an audio sensory signal and wherein one or more of the sensory signals is missing from the AV signal;

reconstructing the one or more missing sensory signals from one or more of the sensory signals present in the AV signal to generate one or more reconstructed sensory signals;

and to generate one or more reconstructed sensory signals; and

performing attentional fusion to generate a pain score for the subject from the one or more sensory signals extracted from the AV signal and the one or more reconstructed sensory signals, wherein performing attentional fusion comprises generating attentive features for the one or more sensory signals extracted from the AV signal and the one or more reconstructed sensory signals and concatenating the generated attentive features to generate the pain score.

12 . The medium of claim 9 , wherein extracting the one or more sensory signals from the AV signal further comprises:

training a multimodal autoencoder to extract spatio-temporal features from AV signals under different missing sensory signal conditions;

extracting spatio-temporal features from the one or more sensory signals of the AV signal using the trained multimodal autoencoder; and

generating a spatio-temporal latent space from the extracted spatio-temporal features using the trained multimodal autoencoder.

13 . The medium of claim 12 , wherein reconstructing the one or more missing sensory signals to generate one or more reconstructed sensory signals further comprises:

generating a joint probability latent space from the spatio-temporal latent space, wherein the joint probability latent space comprises latent features; and

reconstructing the one or more missing sensory signals from the joint probability latent space.

14 . The medium of claim 9 , wherein the pain score comprises an intensity estimation.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 21, 2023
From: SALEKIN, MD SIRAJUS; ALZAMZMI, GHADH; GOLDGOF, DMITRY; SUN, YU; HO, THAO; MOUTON, PETER RANDOLPH
To: UNIVERSITY OF SOUTH FLORIDA
Reel/Frame 063399/0001 →
Continuity (5)
Continuation In Part 17093070 · Nov 9, 2020
Continuation In Part 14989500 · Jan 6, 2016
Provisional Application 62967375 · Jan 29, 2020
Provisional Application 62186956 · Jun 30, 2015
Related Publication 20230309915A1 · Oct 5, 2023
References Cited (96)
US 5810392A · Gagnon · 1998 [cited by applicant]
US 5844488A · Musick · 1998 [cited by applicant]
US 6067019A · Scott · 2000 [cited by applicant]
US 7142697B2 · Huang et al. · 2006 [cited by applicant]
US 8764650B2 · Schiavenato et al. · 2014 [cited by applicant]
US 10827973B1 · Alzamzmi et al. · 2020 [cited by applicant]
US 11202604B2 · Alzamzmi et al. · 2021 [cited by applicant]
US 20060128263A1 · Baird · 2006 [cited by applicant]
US 20080235030A1 · Sisto et al. · 2008 [cited by applicant]
US 20120088985A1 · Schiavenato et al. · 2012 [cited by applicant]
US 20140276188A1 · Jardin · 2014 [cited by applicant]
US 20150269424A1 · Bacivarov et al. · 2015 [cited by applicant]
US 20170098122A1 · el Kaliouby et al. · 2017 [cited by applicant]
US 20170109571A1 · McDuff et al. · 2017 [cited by applicant]
US 20170156661A1 · Hughes · 2017 [cited by examiner]
US 20180039745A1 · Chevalier et al. · 2018 [cited by applicant]
US 20180289334A1 · De Brouwer et al. · 2018 [cited by applicant]
CA 2986863A1 · 2018 [cited by applicant]
CN 106682616A · 2017 [cited by applicant]
CN 106778657A · 2017 [cited by applicant]
CN 107358180A · 2017 [cited by applicant]
CN 107392109A · 2017 [cited by applicant]
CN 107491740A · 2017 [cited by applicant]
CN 114639138A · 2022 [cited by examiner]
JP 2016186802A · 2016 [cited by applicant]
WO 2014036263A1 · 2014 [cited by applicant]
International Search Report and Written Opinion issued for International Application No. PCT/US19/28277 on Jul. 15, 2019. [cited by applicant]
Hazelhoff et al., Behavioral state detection of newborns based on facial expression analysis, International Conference on Advanced Concepts for Intelligent Vision Systems. Springer, Berlin, Heidelberg, 2009. [cited by applicant]
Holsti et al., Body movements: an important additional factor in discriminating pain from stress in preterm infants, The Clinical journal of pain 2005; 21(6): 491-498. [cited by applicant]
Lu et al., Facial expression recognition for neonatal pain assessment, 2008 International Conference on Neural Networks and Signal Processing. IEEE, Jun. 8-10, 2008. [cited by applicant]
Arif-Rahu et al., Bio behavioral measures for pain in the pediatric patient. Pain Management Nursing 13.3 (2012): pp. 157-168. [cited by applicant]
Bagnato et al. Robust infants face tracking using active appearance models: a mixed-state CONDENSATION approach. Advances in Visual Computing. Springer Berlin Heidelberg, 2007. pp. 13-23. [cited by applicant]
Beauchemin et al., The computation of optical flow. ACM Computing Surveys (CSUR) vol. 27, No. 3 (1995): pp. 433-466. [cited by applicant]
Brahnam et al., Introduction to neonatal facial pain detection using common and advanced face classification techniques. Advanced Computational Intelligence Paradigms in Healthcare-1. Springer Berlin Heidelberg, 2007. p… [cited by applicant]
Brahnam, et al., Machine assessment of neonatal facial expressions of acute pain. Decision Support Systems vol. 43, No. 4 (2007): pp. 1242-1254. [cited by applicant]
Brahnam et al., Machine recognition and representation of neonatal facial displays of acute pain. Artificial intelligence in medicine vol. 36, No. 3 (2006): pp. 211-222. [cited by applicant]
Craig, K.D., et al., Pain in the preterm neonate: behavioural and physiological indices. Pain, 1993. vol. 52, No. (3): pp. 287-299. [cited by applicant]
Fournier-Charriere et al., EVENDOL, a new behavioral pain scale for children ages 0 to 7years in the emergency department: Design and validation. PAIN® vol. 153, No. 8 (2012): pp. 1573-1582. [cited by applicant]
Gholami et al., Agitation and pain assessment using digital imaging. Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE, 2009, pp. 1-13. [cited by applicant]
Hall et al., The WEKA data mining software: an update. ACM SIGKDD explorations newsletter vol. 11, No. 1, (2009): pp. 1-10. [cited by applicant]
Hammal et al., Automatic detection of pain intensity. Proceedings of the 14th ACM international conference on Multimodal interaction. ACM, 2012, pp. 1-6. [cited by applicant]
Hicks et al., The Faces Pain Scale-Revised: toward a common metric in pediatric pain measurement. Pain vol. 93, No. 2 (2001): pp. 173-183. [cited by applicant]
Holsti et al., Specific Newborn Individualized Developmental Care and Assessment Program movements are associated with acute pain in preterm infants in the neonatal intensive care unit. Pediatrics, 2004. vol. 114, No. 1… [cited by applicant]
Hummel, P.A., et al., Clinical reliability and validity of the N-PASS: neonatal pain, agitation and sedation scale with prolonged pain. Journal of perinatology, 2003. vol. 28, No. 1, pp. 55-60. [cited by applicant]
Johnston et al., Experience in a neonatal intensive care unit affects pain response. Pediatrics vol. 98, No. 5 (1996): pp. 925-930. [cited by applicant]
Kohavi, A study of cross-validation and bootstrap for accuracy estimation and model selection. IJCAI, vol. 14. No. 2. 1995, pp. 1-8. [cited by applicant]
Lienhart et al., An Extended Set of Haar-like Features for Rapid Object Detection. IEEE ICIP 2002, vol. 1, pp. 900-903, Sep. 2002. [cited by applicant]
Lindh et al., Heel lancing in term new-born infants: an evaluation of pain by frequency domain analysis of heart rate variability. Pain vol. 80, No. 1 (1999): pp. 143-148. [cited by applicant]
Nanni et al., A local approach based on a Local Binary Patterns variant texture descriptor for classifying pain states. Expert Systems with Applications vol. 37, No. 12 (2010): pp. 7888-7894. [cited by applicant]
Saragih et al., Face alignment through subspace constrained mean-shifts. In International Conference of Computer Vision, Sep. 2009, pp. 1-8. [cited by applicant]
Shreve et al., Automatic Expression Spotting in Videos, Image and Vision Computing, vol. 32, No. 8, pp. 476-486, 2014. [cited by applicant]
Shreve et al., Macro- and micro- expression spotting in long videos using spatio-temporal strain. International Conference on Automatic Face and Gesture Recognition, pp. 51-56, c 2012 IEEE, Mar. 2011. [cited by applicant]
Shreve et al., Towards macro- and micro- expressions spotting in videos using strain patterns. Workshop on Applications of Computer Vision, Dec. 2009, pp. 1-6. [cited by applicant]
Valeri et al., Pain in preterm infants: Effects of sex, gestational age, and neonatal illness severity. Psychology & Neuroscience. vol. 5, No. 1, pp. 11-19. [cited by applicant]
Viola et al., Rapid Object Detection using a Boosted Cascade of Simple Features. IEEE CVPR, 2001, pp. I-511-I-518. [cited by applicant]
Viola et al., Robust real-time face detection. International journal of computer vision vol. 57, No. 2, (2004): pp. 137-154. [cited by applicant]
Wilson et al., Facial feature detection using Haar classifiers. Journal of Computing Sciences in Colleges vol. 21, No. 4 (2006): pp. 127-133. [cited by applicant]
Evans et al., Longitudinal comparison of preterm pain responses to repeated heelsticks. Pediatric nursing, 2005. vol. 31, No. 3: pp. 216-221. [cited by applicant]
Fotiadou et al., Video-based facial discomfort analysis for infants, Proc. SPIE 9029, Visual Information Processing and Communication V, 90290F, 2014, pp. 1-14. [cited by applicant]
Gibbins, S., et al., Comparison of pain responses in infants of different gestational ages. Neonatology, 2008. vol. 93, No. 1: pp. 10-18. [cited by applicant]
Hudson-Barr et al., Validation of the pain assessment in neonates (PAIN) scale with the neonatal infant pain scale (NIPS). Neonatal Network. vol. 21, No. 6: pp. 15-21. [cited by applicant]
Petroni, Marco, et al. Identification of pain from infant cry vocalizations using artificial neural networks (ANNs). SPIE's 1995 Symposium on OE/Aerospace Sensing and Dual Use Photonics. International Society for Optics… [cited by applicant]
Brahnam et al., Neonatal Facial Pain Detection Using NNSOA and LSVM. Ipcv. 2008, pp. 1-7. [cited by applicant]
Anand, Consensus statement for the prevention and management of pain in the newborn. Archives of pediatrics & adolescent medicine vol. 155, No. 2, (2001): pp. 173-180. [cited by applicant]
Allegaert et al., Variability in pain expression characteristics in former preterm infants, J. Perinat. Med. vol. 33, No. 5, (2005) pp. 442-448. [cited by applicant]
Hummel et al., N-PASS: Neonatal Pain, Agitation and Sedation Scale—Reliability and Validity, Poster presented at: the Pediatric Academic Societies annual meeting, Pediatrics/Neonatology, Loyola University Medical Center… [cited by applicant]
Lawrence, The development of a tool to assess neonatal pain. Neonatal network: NN vol. 12, No. 6, (1993): pp. 59-66. [cited by applicant]
Awais et al., Can pre-trained convolutional neural networks be directly used as a feature extractor for video-based neonatal sleep and wake classification? BMC Res Notes (2020) 13:507. [cited by applicant]
Awais et al., Novel Framework: Face Feature Selection Algorithm for Neonatal Facial and Related Attributes Recognition, IEEE Access, vol. 8, 59100-59113, Mar. 2020. [cited by applicant]
Brahnam et al., Neonatal pain detection in videos using the iCOPEvid dataset and an ensemble of descriptors extracted from Gaussian of Local Descriptors, Applied Computing and Informatics, Emerald Insight, May 2019, htt… [cited by applicant]
Celona et al., Neonatal Facial Pain Assessment Combining Hand-Crafted and Deep Features, ICIAP 2017 International Workshops, LNCS 10590, pp. 197-204, 2017. [cited by applicant]
Celona et al., Getting the most of few data for neonatal pain assessment, Pervasive Health '19, May 20-23, 2019, Trento, Italy, pp. 298-301. [cited by applicant]
Dosso et al., Video-Based Neonatal Motion Detection, 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), pp. 6135-6138. IEEE, 2020. [cited by applicant]
Egede et al., Automatic Neonatal Pain Estimation: An Acute Pain in Neonates Database, 2019 8th International Conference on Affective Computing and Intelligent Interaction (ACII), pp. 475-481. IEEE, 2019. [cited by applicant]
Hammal et al., Automatic Action Unit Detection in Infants Using Convolutional Neural Network, 2017 Seventh International Conference on Affective Computing and Intelligent Interaction (ACII), pp. 216-221. IEEE, 2017. [cited by applicant]
Homutov et al., Device for Pain Syndrome Study, 2020 International Conference on Industrial Engineering, Applications and Manufacturing (ICIEAM), May 18-22, 2020. [cited by applicant]
Backus, “Validation of the Neonatal Infant Pain Scale” (1996). Masters Theses. 280. [cited by applicant]
Hudson-Barr, Validation of the Pain Assessment in Neonates (PAIN) Scale with the Neonatal Infant Pain Scale (NIPS), Neonatal Network, vol. 21, No. 6, Sep./Oct. 2002, pp. 15-21. [cited by applicant]
Lakshminarayan et al., Three-level Training of Multi-Head Architecture for Pain Detection, 2020 15th IEEE International Conference on Automatic Face and Gesture Recognition (FG 2020), Nov. 2020. [cited by applicant]
Li et al., Infant Monitoring System for Real-Time and Remote Discomfort Detection, IEEE Transactions on Consumer Electronics, vol. 66, No. 4, Nov. 2020. [cited by applicant]
Li et al., Video-based Discomfort Detection for Infants Using a Constrained Local Model, IWSSIP 2016—The 23rd International Conference on Systems, Signals and Image Processing. May 23-25, 2016, Bratislava, Slovakia. [cited by applicant]
Lu et al., Learning Pyramidal Hierarchical Features for Neonatal Face Detection, 2018 14th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD), 2018. [cited by applicant]
Mansor et al., Pain Assessment Using Neural Network Classifier, 2012 International Symposium on Instrumentation & Measurement, Sensor Network and Automation (IMSNA), 2012, pp. 377-379. [cited by applicant]
Monwar et al., Pain Recognition Using Artificial Neural Network, 2006 IEEE International Symposium on Signal Processing and Information Technology, 2006, pp. 28-33. [cited by applicant]
Parodi et al., Automated Newborn Pain Assessment Framework Using Computer Vision Techniques, In Proceedings of the International Conference on Bioinformatics Research and Applications 2017, pp. 31-36. 2017. [cited by applicant]
Sun et al., Automatic and Continuous Discomfort Detection for Premature Infants in a NICU Using Video-Based Motion Analysis, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Soci… [cited by applicant]
Sun et al., Respiration Monitoring for Premature Neonates in NICU, Applied Sciences 9, No. 23, 2019, 5246. [cited by applicant]
Sun et al., Automated discomfort detection for premature infants in NICU using time-frequency feature-images and CNNs, Proc. SPIE 11314, Medical Imaging 2020: Computer-Aided Diagnosis, 113144B, Mar. 16, 2020. [cited by applicant]
Villarroel et al., Non-contact physiological monitoring of preterm infants in the Neonatal Intensive Care Unit, Nature Partner Journals, Digital Medicine (2019) 128. [cited by applicant]
Werner et al., Automatic Recognition Methods Supporting Pain Assessment: A Survey, Submission to IEEE Trans. on Affective Computing, vol. X, No. Y, Jul. 2019. [cited by applicant]
Xu et al., Towards Automated Pain Detection in Children using Facial and Electrodermal Activity, CEUR Workshop Proc. Jul. 2018 ; 2142: 208-211. [cited by applicant]
Xu et al., Exploring Multidimensional Measurements for Pain Evaluation using Facial Action Units, 2020 15th IEEE International Conference on Automatic Face and Gesture Recognition, 2020. [cited by applicant]
Yan et al., FENP: A Database of Neonatal Facial Expression for Pain Analysis, IEEE Transactions on Affective Computing, 2020. [cited by applicant]
Zamzmi et al., A Review of Automated Pain Assessment in Infants: Features, Classification Tasks, and Databases, IEEE Reviews in Biomedical Engineering, vol. 11, 2018. [cited by applicant]
Zeng et al., PIC, a paediatric-specific intensive care database, Scientific Data, 7:14, 2020. [cited by applicant]
Zhi et al., A comprehensive survey on automatic facial action unit analysis, The Visual Computer (2020) 36:1067-1093. [cited by applicant]