Pharmaceutical composition comprising 4-hexylresorcinol as active ingredient for prevention or treatment of bone disease
The present invention relates to a composition comprising 4-hexylresorcinol (4-HR) as an active ingredient for prevention or treatment of a bone disease, and a formulation thereof. The composition comprising 4-hexylresorcinol (4-HR) as an active ingredient, or an ointment thereof was found to improve bone thickness, density, and strength and control bone remodeling by promoting the differentiation of osteoblasts and suppressing the proliferation and differentiation of osteoclasts in osteoporosis-induced animal models. Thus, the composition or ointment comprising 4-hexylresorcinol (4-HR) as an active ingredient can be provided as a therapeutic agent for bone diseases including bone fracture, osteoarthritis, rheumatoid arthritis, and osteoporosis.
1 . A method of simultaneously treating osteoporosis and reducing abdominal fat accumulation in a subject in need thereof, comprising:
topically applying an effective amount of a pharmaceutical ointment composition comprising about 2% by weight 4-hexylresorcinol (4-HR) in lanolin oil to a dorsal skin are of the subject,
wherein the 4-hexylresorcinol (4-HR) decreases a level of CTX in blood, increases a level of ALP, promotes differentiation of osteoblasts, and suppresses differentiation of osteoclasts, and
wherein said applying increases bone volume, bone density, and bone thickness, and reduces abdominal fat accumulation in the subject.