Drying method for polyglycollide warp-knitted support meshes for artificial skin
The invention relates to a drying method for polyglycollide warp-knitted support meshes for artificial skin, specifically comprising: pre-drying, deep drying, and fabric stress relaxation, which are performed sequentially. The drying method can completely remove water in polyglycollide warp-knitted support meshes as well as solvents left during the cleaning process, and can effectively maintain the properties such as tensile strength, pore size, and weight of the polyglycollide warp-knitted support meshes, thus being of great significance for the application of the polyglycollide warp-knitted support meshes in the field of medical artificial skin.
1 . A drying method for polyglycollide warp-knitted support meshes for artificial skin, specifically comprising: pre-drying, deep drying, and fabric stress relaxation, which are performed sequentially, the pre-drying being completed in a vacuum drying oven A, and the deep drying and the fabric stress relaxation being completed in a vacuum drying oven B, wherein:
the process of pre-drying comprises: placing a polyglycollide warp-knitted support mesh, which is aired after being cleaned, in the vacuum drying oven A which is connected to a water-circulation vacuum pump, and setting a temperature in the vacuum drying oven A as T 1 ; starting the water-circulation vacuum pump, keeping the vacuum drying oven running to treat the polyglycollide warp-knitted support mesh in the vacuum drying oven A under a vacuum degree P 1 for a time t 1 , and then stopping the water-circulation vacuum pump; and slowly introducing air into the vacuum drying oven A to enable the vacuum drying oven A to return to normal pressure;
the process of deep drying comprises: (1) placing the polyglycollide warp-knitted support mesh in the vacuum drying oven B which is connected to a sliding-vane rotary vacuum pump and an inert gas connecting tube; (2) at normal temperature, starting the sliding-vane rotary vacuum pump to decrease a vacuum degree of the vacuum drying oven B to P 2 , then stopping the sliding-vane rotary vacuum pump, and introducing an inert gas into the vacuum drying oven B to enable the vacuum drying oven B to return to normal pressure; (3) performing Step (2) multiple times; (4) starting the sliding-vane rotary vacuum pump, keeping the sliding-vane rotary vacuum pump running to perform drying treatment on the polyglycollide warp-knitted support mesh in the vacuum drying oven B under a vacuum degree P 2 and a temperature T 2 for a time t 2 ; and (5) under the condition where the vacuum degree of the vacuum drying oven B is maintained at P 2 , increasing the temperature in the vacuum drying oven B to T 3 at a heating rate T, maintaining the temperature in the vacuum drying oven B at T 3 to treat the polyglycollide warp-knitted support mesh for a time t 3 , and stopping the sliding-vane rotary vacuum pump;
the process of fabric stress relaxation comprises: introducing an inert gas into the vacuum drying oven B at a rate V, increasing the temperature in the vacuum drying box B to T 4 , treating the polyglycollide warp-knitted support mesh at the temperature T 4 for a time t 4 , and then cooling the vacuum drying box B to normal temperature.
2 . The drying method for polyglycollide warp-knitted support meshes for artificial skin according to claim 1 , wherein the temperature T 1 is 25° C.-35° C., the vacuum degree P 1 is 0-400 Pa, and the treatment time t 1 is 1-2.5 h.
3 . The drying method for polyglycollide warp-knitted support meshes for artificial skin according to claim 1 , wherein the inert gas is one of nitrogen, argon, and helium.
4 . The drying method for polyglycollide warp-knitted support meshes for artificial skin according to claim 1 , wherein the vacuum degree P 2 of the vacuum drying oven B is 0-50 Pa, Step (2) is performed two or more times in Step (3), the temperature T 2 is 65° C.-75° C., the time t 2 is 3-5 h, the heating rate T is 16° C./h-24° C./h, the temperature T 3 is 85° C.-105° C., and the time t 3 is 1/3-1 h.
5 . The drying method for polyglycollide warp-knitted support meshes for artificial skin according to claim 1 , wherein in the process of fabric stress relaxation, the rate V is 0.1 L/min-1 L/min, the temperature T 4 is 110° C.-130° C., and the time t 4 is 3-5 h.