Frequency domain-based methods for his bundle capture classification
Systems and methods for His bundle pacing and classifying response to pacing impulses include applying, using a pulse generator, an impulse through a stimulating electrode to induce a response from a patient heart. A response to the impulse is measured using at least one sensing electrode and frequency characteristics of the response are analyzed to determine whether His bundle capture has occurred and, if so, what type of capture has occurred. To facilitate analysis, the response measured from the patient heart may also be filtered to pass or stop frequencies indicative of certain capture types.
1 . A method of pacing a His bundle of a patient heart using a stimulation system, the stimulation system having a memory, a pulse generator, a stimulating electrode in proximity to the His bundle, a first filter configured to pass a first frequency component corresponding to a first capture type, a second filter configured to pass a second frequency component corresponding to a second capture type, and at least one sensing electrode adapted to sense electrical activity of the patient heart, the method comprising:
applying, using the pulse generator, an impulse through the stimulating electrode to induce a response from the patient heart;
measuring, using the at least one sensing electrode, an electrical activity response of the patient heart to application of the impulse;
applying the first filter to the electrical activity response to generate a first filtered response;
applying the second filter to the electrical activity response to generate a second filtered response; and
analyzing one or more frequency characteristics of at least one of the first or second filtered response to determine whether application of the impulse resulted in the first or second capture type of the His bundle.
2 . A method of pacing a patient heart using a stimulation system, the stimulation system having a memory, a pulse generator, a stimulating electrode in proximity to a His bundle, and at least one sensing electrode adapted to sense electrical activity of the patient heart, the method comprising:
applying, using the pulse generator, an impulse through the stimulating electrode to induce a response from the patient heart;
measuring, using the at least one sensing electrode, a response of the patient heart to application of the impulse; and
analyzing one or more frequency characteristics of the response to determine whether application of the impulse resulted in capture, wherein analyzing the one or more frequency characteristics of the response comprises:
generating a frequency spectrum of the response; and
identifying a capture type based on one or more frequency spectrum characteristics of the frequency spectrum.
3 . The method of claim 2 , wherein the one or more frequency spectrum characteristics includes at least one of:
a frequency component of the frequency spectrum having a particular frequency;
a frequency component of the frequency spectrum being above a threshold frequency;
a frequency component of the frequency spectrum being below the threshold frequency;
a frequency component of the frequency spectrum having a minimum amplitude;
an average amplitude of a plurality of frequency components of the frequency spectrum; or
a relative proportion of a first frequency component of the frequency spectrum to a second frequency component of the frequency spectrum.
4 . The method of claim 1 , wherein the first filter includes a low pass filter, the low pass filter having a cutoff frequency configured to stop high frequencies indicative of selective capture, the low pass filter generating the first filtered response that is analyzed.
5 . The method of claim 1 , wherein the first second filter includes a band pass filter having a frequency band configured to at least one of pass frequencies indicative of selective capture or stop frequencies indicative of myocardium-only capture, the bandpass filter generating the first filtered response that is analyzed.
6 . The method of claim 1 , further comprising generating a filtered frequency spectrum of the first and second filtered responses.
7 . The method of claim 6 , wherein the one or more frequency characteristics of the first and second filtered responses include at least one of
a frequency component of the filtered frequency spectrum having a particular frequency;
a frequency component of the filtered frequency spectrum being above a threshold frequency;
a frequency component of the filtered frequency spectrum being below the threshold frequency;
a frequency component of the filtered frequency spectrum having a minimum amplitude;
an average amplitude of a plurality of frequency components of the filtered frequency spectrum; or
a relative proportion of a first frequency component of the filtered frequency spectrum to a second frequency component of the filtered frequency spectrum.
8 . The method of claim 1 , wherein the first and second capture types correspond to myocardium-only capture and loss of capture, respectively, the method further comprising, in response to determining the impulse resulted in one of myocardium-only capture or loss of capture, initiating a threshold search to adjust an impulse setting of the stimulation system.
9 . A cardiac stimulation system adapted to deliver impulses for pacing a His bundle of a patient heart using a stimulation electrode and to sense response characteristics of the His bundle and myocardium of the patient heart using one or more sensing electrodes in response to impulses delivered by the stimulation electrode, the stimulation system comprising:
a pulse generator adapted to generate electrical impulses for pacing the His bundle;
a first filter configured to pass a first frequency component corresponding to a first capture type;
a second filter configured to pass a second frequency component corresponding to a second capture type;
a processor communicatively coupled to the pulse generator and adapted to receive response characteristics from the one or more sensing electrodes; and
a memory communicatively coupled to the processor, the memory including instructions executable by the processor that, when executed by the processor, cause the processor to:
apply, using the pulse generator, an impulse through the stimulating electrode to induce a response from the patient heart;
measure, using the one or more sensing electrodes, an electrical activity response of the patient heart to application of the impulse;
apply the first filter to the electrical activity response to generate a first filtered response;
apply the second filter to the electrical activity response to generate a second filtered response; and
analyze one or more frequency characteristics of at least one of the first or second filtered response to determine whether application of the impulse resulted in the first or second capture type of the His bundle.
10 . A cardiac stimulation system adapted to deliver impulses for pacing a His bundle of a patient heart using a stimulation electrode and to sense response characteristics of the His bundle and myocardium of the patient heart using one or more sensing electrodes in response to impulses delivered by the stimulation electrode, the stimulation system comprising:
a pulse generator adapted to generate electrical impulses for pacing the His bundle;
a processor communicatively coupled to the pulse generator and adapted to receive response characteristics from the one or more sensing electrodes; and
a memory communicatively coupled to the processor, the memory including instructions executable by the processor that, when executed by the processor, cause the processor to:
apply, using the pulse generator, an impulse through the stimulating electrode to induce a response from the patient heart;
measure, using the one or more sensing electrodes, a response of the patient heart to application of the impulse; and
analyze one or more frequency characteristics of the response to determine whether application of the impulse resulted in capture of the His bundle,
wherein the instructions cause the processor to analyze one or more frequency characteristics of the response by:
generating a frequency spectrum of the response; and
identifying a capture type based on characteristics of the frequency spectrum.
11 . The cardiac stimulation system of claim 9 , wherein
the first and second filters represent low pass and bandpass filters, respectively, that are applied to the electrical activity response to generate both of the first and second filtered responses, the low pass and bandpass filters configured to modify frequencies of the electrical activity response indicative of a particular one of the first and second capture types.
12 . The method of claim 1 , wherein the one or more frequency characteristics includes a frequency component, the analyzing includes analyzing the frequency component to determine whether application of the impulse resulted in capture.
13 . The method of claim 2 , wherein the response is indicative of travel of myocardial depolarization through at least one of the His bundle, left bundle, right bundle, or Purkinje fibers.
14 . The method of claim 2 , wherein the impulse is applied to the stimulating electrode located proximate to one of an atrial or ventricular septum.
15 . The cardiac stimulation system of claim 9 , wherein the one or more frequency characteristics includes a frequency component, and wherein the instructions cause the processor to analyze one or more frequency characteristics of the response by analyzing the frequency component to determine whether application of the impulse resulted in capture.
16 . The cardiac stimulation system of claim 9 , wherein the response is indicative of travel of myocardial depolarization through at least one of the His bundle, left bundle, right bundle, or Purkinje fibers.
17 . The method of claim 1 , wherein the first capture type corresponds to one of selective capture, non-selective capture, myocardium-only capture, and loss of capture, and the second capture type corresponds to another of selective capture, non-selective capture, myocardium-only capture, and loss of capture.
18 . The cardiac stimulation system of claim 9 , wherein the first capture type corresponds to one of selective capture, non-selective capture, myocardium-only capture, and loss of capture, and the second capture type corresponds to another of selective capture, non-selective capture, myocardium-only capture, and loss of capture.
19 . The cardiac stimulation system of claim 9 , wherein the first filter includes a low pass filter, the low pass filter having a cutoff frequency configured to stop high frequencies indicative of selective capture, the low pass filter generating the first filtered response that is analyzed.
20 . The cardiac stimulation system of claim 9 , wherein the second filter includes a band pass filter having a frequency band configured to at least one of pass frequencies indicative of selective capture or stop frequencies indicative of myocardium-only capture, the bandpass filter generating the first filtered response that is analyzed.
21 . The cardiac stimulation system of claim 9 , wherein the instructions cause the processor to generate a filtered frequency spectrum of the first and second filtered responses.
22 . The cardiac stimulation system of claim 21 , wherein the instructions cause the processor to analyze the one or more frequency characteristics of both of the first and second filtered responses to identify at least one of:
a frequency component of the filtered frequency spectrum having a particular frequency;
a frequency component of the filtered frequency spectrum being above a threshold frequency;
a frequency component of the filtered frequency spectrum being below the threshold frequency;
a frequency component of the filtered frequency spectrum having a minimum amplitude;
an average amplitude of a plurality of frequency components of the filtered frequency spectrum; or
a relative proportion of a first frequency component of the filtered frequency spectrum to a second frequency component of the filtered frequency spectrum.