IP Library Granted Patent US 12,522,426
Granted Patent B2
US 12,522,426 · App. 18/240,817 · Granted Jan 13, 2026

Systems and methods for shipping cryogenically-frozen materials

Inventors: Brian A. Wallin (Nashua, IA); Frank D. Obrad (Mansfield, TX); Craig T. Vermeyen (Santa Monica, CA)
Assignee: Kite Pharm, Inc.
B65D85/30B65D45/02B65D81/1275F17C13/006B65D2201/00F17C2270/0509
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Quick Facts
Patent No.
US 12,522,426
App. No.
18/240,817
Granted
Jan 13, 2026
Kind
B2
Abstract

Embodiments of the disclosure relate to shipping cases, dewars, and systems for transporting a frozen material. More specifically, the embodiments described herein include and/or enable dewar lid protective systems, data logging enablement, controlled coolant escape, efficient stacking options during transport, spill protection to ensure safe and effective transport of frozen samples and materials among other things. An exemplary use for the systems described herein includes reliable shipping for frozen materials at specified environmental conditions which can be tracked and verified.

Claims (37)

1 . A cryogenic dewar for shipping a frozen material comprising:

an insulated housing comprising:

a cavity for containing said frozen material; and

a plurality of load-bearing handles disposed on an upper and outer surface of said insulated housing; and

a lid configured to reversibly engage with said insulated housing such that said lid forms a seal over said insulated housing when said lid is engaged with said insulated housing,

wherein said plurality of load-bearing handles extend in a vertical direction at least even with said lid when said lid is engaged with said insulated housing,

wherein said lid is configured to reversibly house a condition monitoring system; and

a vapor plug at least partially encased with a hydrophobic fleece over the vapor plug, such that said hydrophobic fleece is configured to allow escape of liquid nitrogen vapors from insulated housing of said cryogenic dewar at a reduced rate.

2 . The cryogenic container of claim 1 , wherein said plurality of load-bearing handles extend in a vertical direction beyond said lid when said lid is engaged with said insulated housing.

3 . The cryogenic container of claim 2 , further comprising a temperature-probe locking system reversibly coupled to an inside surface of said cavity.

4 . A system for transporting a frozen material comprising:

a cryogenic dewar for shipping said frozen material comprising:

an insulated housing comprising:

a cavity for containing said frozen material; and

a plurality of load-bearing handles disposed on an upper and outer surface of said insulated housing; and

a dewar lid configured to reversibly engage with said insulated housing such that said dewar lid forms a seal over said insulated housing when said dewar lid is engaged with said insulated housing; and

a shipping case configured to house said cryogenic dewar when in use, said shipping case comprising:

a lined compartment comprising:

a bottom;

one or more walls extending from said bottom, such that said bottom and one or more walls form a cavity and an opening for accessing said cavity, said opening disposed opposite said bottom; and

a shock-absorbing lining disposed on an inner surface of said one or more walls and configured to accept said cryogenic dewar;

a lid configured to reversibly engage with said lined compartment such that said lid forms a seal over said lined compartment when said lid is engaged with said lined compartment,

wherein said plurality of load-bearing handles extend in a vertical direction at least even with said dewar lid when said lid is engaged with said insulated housing,

wherein said dewar lid is configured to reversibly house a condition monitoring system, and

wherein said shock-absorbing lining is up to 1.75 inches in thickness, or between 1 to 1.75 inches in thickness, or about 1 inch in thickness; and

a vapor plug at least partially encased with a hydrophobic fleece over the vapor plug, such that said hydrophobic fleece is configured to allow escape of liquid nitrogen vapors from insulated housing of said cryogenic dewar at a reduced rate.

5 . The system of claim 4 , wherein said plurality of load-bearing handles extend in a vertical direction beyond said lid when said lid is engaged with said insulated housing.

6 . The system of claim 5 , further comprising a temperature-probe locking system reversibly coupled to an inside surface of said cavity.

7 . The system of claim 4 , further comprising a plurality of draw latches, each of said plurality of draw latches comprising a first member disposed on said lined compartment and a corresponding second member disposed on said lid, and such that said plurality of draw latches are configured to reversibly couple said lid to said lined compartment when each of said first members are engaged with said corresponding second members.

8 . The system of claim 7 , wherein said lined compartment further forms a plurality of openings, each of said plurality of openings configured to accept a fastener for securing said plurality of draw latches.

9 . The system of claim 8 , wherein said lid further comprises a ridge structure disposed on an outer and top surface of said lid,

wherein said bottom further forms a slot disposed on an outer and bottom surface of said bottom, and

wherein said slot is configured to accept said ridge structure such that a pair of shipping cases can be stacked on top of one another such that a first container comprising said slot can be secured onto a second shipping container comprising said ridge structure.

10 . The system of claim 9 , wherein said bottom is configured to reversibly couple to a pallet for facilitated transportation.

11 . The system of claim 10 , further comprising a label plaque attached to an outer surface of at least one of said one or more walls.

12 . The system of claim 11 , wherein said shock-absorbing lining forms a plurality of recessed air vents for facilitated insertion and removal of said cryogenic shipping container.

13 . The system of claim 12 , wherein said shock-absorbing layer forms a slot configured to reversibly secure a data logger.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 24, 2023
From: WALLIN, BRIAN A.; OBRAD, FRANK D.; VERMEYEN, CRAIG T.
To: KITE PHARMA, INC.
Reel/Frame 065656/0588 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 16, 2023
From: WALLIN, BRIAN A.; OBRAD, FRANK D.; VERMEYEN, CRAIG T.
To: KITE PHARMA, INC.
Reel/Frame 065590/0398 →
Continuity (2)
Provisional Application 63374346 · Sep 1, 2022
Related Publication 20240076117A1 · Mar 7, 2024
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