Granted Patent B2

US 12,527,344 · App. 17/290,323 · Granted Jan 20, 2026

Inventor: Ross Cabot (London, GB)

Assignee: NICOVENTURES TRADING LIMITED

A24B15/167

Abstract

Claims (37)

1 . An aerosolizable formulation comprising

(i) water in an amount of at least 50 wt. % based on the aerosolizable formulation;

ii) nicotine;

(iii) one or more acids present in a total amount of from 0.2 to 1 wt. % based on the aerosolizable formulation; and

(iv) one or more cyclodextrins,

wherein the molar ratio of the one or more acids to the nicotine is from 5:1 to 1:1.

2 . The aerosolizable formulation according to claim 1 , wherein water is present in an amount of at least 75 wt. % based on the aerosolizable formulation.

3 . The aerosolizable formulation according to claim 1 , wherein water is present in an amount of at least 90 wt. % based on the aerosolizable formulation.

4 . The aerosolizable formulation according to claim 1 , wherein the nicotine is present in an amount of no greater than 1 wt. % based on the aerosolizable formulation.

5 . The aerosolizable formulation according to claim 4 , wherein the nicotine is present in an amount of from 0.01 to 0.6 wt. % based on the aerosolizable formulation.

6 . The aerosolizable formulation according to claim 1 , wherein at least 5 wt. % of the nicotine present in the formulation is in a protonated form.

7 . The aerosolizable formulation according to claim 1 , wherein at least 50 wt. % of the nicotine present in the formulation is in a protonated form.

8 . The aerosolizable formulation according to claim 1 , wherein at least 90 wt. % of the nicotine present in the formulation is in a protonated form.

9 . The aerosolizable formulation according to claim 1 , wherein the one or more acids is selected from the group consisting of acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof.

10 . The aerosolizable formulation according to claim 1 , wherein the one or more acids comprises citric acid.

11 . The aerosolizable formulation according to claim 1 , further comprising one or more flavors.

12 . The aerosolizable formulation according to claim 11 , wherein the one or more flavors are selected from the group consisting of (4-(para-) methoxyphenyl)-2-butanone, vanillin, γ-undecalactone, menthone, 5-propenyl guaethol, menthol, para-mentha-8-thiol-3-one and mixtures thereof.

13 . The aerosolizable formulation according to claim 11 , wherein the one or more flavors comprises menthol.

14 . The aerosolizable formulation according to claim 11 , wherein the one or more flavors are present in a total amount of no greater than 2 wt. % based on the aerosolizable formulation.

15 . The aerosolizable formulation according to claim 11 , wherein the one or more flavors are present in a total amount of from 0.01 to 1 wt. % based on the aerosolizable formulation.

16 . A process for forming an aerosol, the process comprising aerosolizing the aerosolizable formulation of claim 1 .

17 . The process according to claim 16 , wherein the aerosolizable formulation is aerosolized to form the aerosol at a temperature below 50° C.

18 . The process according to claim 16 , wherein aerosolizing the aerosolizable formulation comprises applying ultrasonic energy to the aerosolizable formulation.

19 . The aerosolizable formulation according to claim 1 , wherein the aerosolizable formulation is contained within a container.

20 . The contained aerosolizable formulation according to claim 19 , wherein the container is configured for engagement with an electronic aerosol provision system.

21 . An electronic aerosol provision system comprising:

(a) an aerosolizer for aerosolizing an aerosolizable formulation for inhalation by a user of the electronic aerosol provision system;

(b) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(c) the aerosolizable formulation, comprising:

(i) water in an amount of at least 50 wt. % based on the aerosolizable formulation;

(ii) nicotine;

(iii) one or more acids present in a total amount of from 0.2 to 1 wt. % based on the aerosolizable formulation; and

(iv) one or more cyclodextrins,

wherein the molar ratio of the one or more acids to the nicotine is from 5:1 to 1:1.

22 . A process for improving the sensory properties of an aerosolized nicotine formulation, the process comprising the steps of:

(a) providing an aerosolizable material comprising (i) water in an amount of at least 50 wt. % based on the aerosolizable material and (ii) nicotine; and

(b) incorporating into the aerosolizable material one or more acids and one or more cyclodextrins, wherein the one or more acids are present in a total amount of from 0.2 to 1 wt. % based on the aerosolizable formulation, and wherein the molar ratio of the one or more acids to the nicotine is from 5:1 to 1:1.

Priority Claims (1)

Continuity (1)

References Cited (221)