IP Library › Granted Patent US 12,527,735
Granted Patent B2
US 12,527,735 · App. 17/894,098 · Granted Jan 20, 2026

Oral care compositions and methods

Inventors: Carl Myers (Wayne, NJ); Gokul Govindaraju (Somerville, NJ)
Assignee: Colgate-Palmolive Company
A61K8/97A61K8/19A61K8/20A61K8/21A61Q11/00A61K2800/262A61K2800/28A61K2800/42A61K2800/92
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Quick Facts
Patent No.
US 12,527,735
App. No.
17/894,098
Granted
Jan 20, 2026
Kind
B2
Abstract

This application relates to novel black translucent oral care compositions useful for combining and delivering incompatible stannous fluoride or stannous chloride and potassium salts in a charcoal composition, for example, to provide effective caries prevention, protection against dental erosion, and relief from dental hypersensitivity. The compositions comprise stannous fluoride or stannous chloride, nitric acid or a water-soluble nitrate salt, a water-soluble alkali metal polyphosphate and more than 10% water, by weight of the composition.

Claims (35)

1 . A black translucent single-component oral care composition comprising:

(i) from 0.1 to 2 wt. % of stannous fluoride or stannous chloride;

(ii) from 0.1 to 5 wt. % of nitric acid or a water-soluble nitrate salt;

(iii) from 0.1 to 5 wt. % of a water-soluble alkali metal polyphosphate comprising tetrasodium pyrophosphate and/or sodium tripolyphosphate;

(iv) more than 10 wt. % of water; and

(v) 0.001 to 0.0080.01 wt. % of charcoal,

wherein all weight percentages are based on the total weight of the black translucent single-component oral care composition,

wherein the composition has a molar ratio of the stannous fluoride or the stannous chloride to the nitric acid or the water-soluble nitrate salt to the tetrasodium pyrophosphate and/or the sodium tripolyphosphate of 1:1:1 to 1:10:1.7, and

wherein the composition is formulated as a dentifrice and has a pH of 5 to 9, and wherein the composition has L*a*b color values of 1-50 for L, and/or −0.1 to 0.1 for a, and/or −0.25 to 0.25 for b, and wherein the oral care composition has a turbidity of less than 1000 NTU, as measured on a 10 mm thick sample.

2 . The oral care composition of claim 1 , wherein the charcoal is present in an amount of 0.005 to 0.0075 wt. %.

3 . The oral care composition of claim 1 , wherein the oral care composition does not comprise any white pigment.

4 . The oral care composition of claim 1 , wherein the water-soluble nitrate salt is selected from an alkali earth metal nitrate, alkaline earth metal nitrate, zinc nitrate, silver nitrate, ammonium nitrate, and a combination thereof.

5 . The oral care composition of claim 1 , wherein the water-soluble nitrate salt is selected from lithium nitrate, sodium nitrate, potassium nitrate, magnesium nitrate, calcium nitrate, and a combination thereof.

6 . The oral care composition of claim 1 , wherein the water-soluble nitrate salt is potassium nitrate.

7 . The oral care composition of claim 1 , wherein the water-soluble alkali metal polyphosphate is selected from a pyrophosphate, tripolyphosphate, tetraphosphate, hexametaphosphate, and a combination thereof.

8 . The oral care composition of claim 7 , wherein the water-soluble alkali metal polyphosphate is selected from sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, potassium tripolyphosphate, and a combination thereof.

9 . The oral care composition of claim 1 , wherein the water-soluble nitrate salt is potassium nitrate and the water-soluble alkali metal polyphosphate salt is tetrasodium pyrophosphate.

10 . The oral care composition of claim 1 , wherein the oral care composition comprises a molar ratio of alkali metal polyphosphate to stannous fluoride or stannous chloride of at least 1:1.

11 . The oral care composition of claim 1 , wherein the oral care composition comprises a molar ratio of the nitric acid or the water-soluble nitrate salt to the stannous fluoride or the stannous chloride of at least 0.3:1.

12 . The oral care composition of claim 1 , wherein the water is present in an amount of at least 15 wt. %.

13 . The oral care composition of claim 1 , wherein the water is present in an amount of 10 to 50 wt. %.

14 . An oral care package comprising the oral care composition according to claim 1 , wherein the package comprises a container comprising a single storage compartment, which compartment contains the oral care composition, and a closure which seals the compartment.

15 . A method of treatment or prevention of gingivitis, plaque, dental caries, and/or dental hypersensitivity, the method comprising the application to the oral cavity of a person in need thereof, of the oral care composition according to claim 1 .

16 . A black translucent single-component oral care composition comprising:

(i) from 0.1 to 2 wt. % of stannous fluoride or stannous chloride;

(ii) from 0.1 to 5 wt. % of nitric acid or a water-soluble nitrate salt;

(iii) from 0.1 to 5 wt. % of a water-soluble alkali metal polyphosphate;

(iv) more than 10 wt. % water; and

(v) an amount up to about 0.008 wt. % of charcoal,

wherein all weight percentages are based on the total weight of the oral care composition,

wherein the oral care composition has a molar ratio of the stannous fluoride or the stannous chloride to the nitric acid or the water-soluble nitrate salt to the tetrasodium pyrophosphate and/or the sodium tripolyphosphate of 1:1:1 to 1:10:1.7, and wherein the oral care composition is formulated as a dentifrice and has a pH of 5 to 9,

wherein the oral care composition is formulated as a dentifrice and has a pH of 5 to 9, and wherein the oral care composition has L*a*b color values of 1-50 for L, and/or −0.1 to 0.1 for a, and/or −0.25 to 0.25 for b, wherein the oral care composition has a turbidity of less than 1000 NTU measured on a 10 mm thick sample.

17 . The black translucent single-component oral care composition according to claim 16 , wherein the water-soluble alkali metal polyphosphate comprises sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, potassium tripolyphosphate, or a combination thereof.

18 . The black translucent single-component oral care composition according to claim 16 , wherein the water-soluble alkali metal polyphosphate comprises sodium pyrophosphate, sodium tripolyphosphate, or a combination thereof.

19 . The black translucent single-component oral care composition according to claim 16 , wherein the water is present in an amount of at least 15 wt. %.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2022
From: MYERS, CARL; GOVINDARAJU, GOKUL
To: COLGATE-PALMOLIVE COMPANY
Reel/Frame 061536/0737 →
Continuity (2)
Provisional Application 63235918 · Aug 23, 2021
Related Publication 20230072484A1 · Mar 9, 2023
References Cited (74)
US 3535421A · Briner et al. · 1970 [cited by applicant]
US 3678154A · Widder et al. · 1972 [cited by applicant]
US 4259316A · Nakashima et al. · 1981 [cited by applicant]
US 4842847A · Amjad · 1989 [cited by applicant]
US 4885155A · Parran, Jr. et al. · 1989 [cited by applicant]
US 4931273A · Gaffar · 1990 [cited by examiner]
US 5258173A · Waterfield · 1993 [cited by applicant]
US 5352439A · Norfleet et al. · 1994 [cited by applicant]
US 5578293A · Prencipe et al. · 1996 [cited by applicant]
US 5693314A · Campbell et al. · 1997 [cited by applicant]
US 5811079A · Yu et al. · 1998 [cited by applicant]
US 6464963B1 · Gambogi et al. · 2002 [cited by applicant]
US 8906347B2 · Strand et al. · 2014 [cited by applicant]
US 8926950B2 · Heckendorn et al. · 2015 [cited by applicant]
US 9724278B2 · Lambert et al. · 2017 [cited by applicant]
US 9937115B2 · Haught et al. · 2018 [cited by applicant]
US 9968803B2 · Fruge et al. · 2018 [cited by applicant]
US 10285919B2 · Rege et al. · 2019 [cited by applicant]
US 10653596B2 · Gininger · 2020 [cited by applicant]
US 10918580B2 · Zhang et al. · 2021 [cited by applicant]
US 20060140881A1 · Xu et al. · 2006 [cited by applicant]
US 20070140986A1 · Prencipe et al. · 2007 [cited by applicant]
US 20110014136A1 · Kohli et al. · 2011 [cited by applicant]
US 20110020247A1 · Strand · 2011 [cited by applicant]
US 20110020248A1 · Strand · 2011 [cited by applicant]
US 20170135936A1 · Shanmugam et al. · 2017 [cited by applicant]
US 20170281486A1 · Midha et al. · 2017 [cited by applicant]
US 20180177695A1 · Miller et al. · 2018 [cited by applicant]
US 20190269606A1 · Price et al. · 2019 [cited by applicant]
US 20200163868A1 · Martinetti · 2020 [cited by examiner]
US 20200197268A1 · Myers et al. · 2020 [cited by applicant]
US 20210000709A1 · Zhang et al. · 2021 [cited by applicant]
US 20210137803A1 · Zhang et al. · 2021 [cited by applicant]
US 20220339228A9 · Kruse et al. · 2022 [cited by applicant]
US 20230072484A1 · Myers et al. · 2023 [cited by applicant]
US 20240050334A1 · Schaeffer-Korbylo · 2024 [cited by examiner]
CA 2199027 · 1996 [cited by applicant]
CA 2858349 · 2013 [cited by applicant]
CN 1418086 · 2003 [cited by applicant]
CN 102612356 · 2012 [cited by applicant]
CN 102946844 · 2013 [cited by applicant]
CN 103648471 · 2014 [cited by applicant]
CN 104069013 · 2014 [cited by applicant]
CN 109328092 · 2019 [cited by applicant]
CN 110087619 · 2019 [cited by applicant]
CN 116648227 · 2023 [cited by applicant]
EP 2374446 · 2011 [cited by applicant]
JP 2015221814A · 2015 [cited by applicant]
WO 1995007682 · 1995 [cited by applicant]
WO 2011124659 · 2011 [cited by applicant]
WO 2016178652 · 2016 [cited by applicant]
WO 2017117363 · 2017 [cited by applicant]
WO 2020131823 · 2020 [cited by applicant]
WO 2020244822 · 2020 [cited by applicant]
WO 2021002910 · 2021 [cited by applicant]
WO WO2021002910A1 · 2021 [cited by examiner]
WO 2022140280 · 2022 [cited by applicant]
WO 2022140281 · 2022 [cited by applicant]
WO 2022140368 · 2022 [cited by applicant]
Anonymous, 2000, “Toothpaste Extension”, Mintel Database GNPD AN: 10076005. [cited by applicant]
Anonymous, 2002, “Flouride Toothpaste for Sensitive Teeth”, Mintel Database GNPD AN: 10111837. [cited by applicant]
Campbell, 1954, “A kinetic study of the hydrolysis of pyrophosphates,” Journal of the American Chemical Society 76 (3):893-901. [cited by applicant]
Myers et al., 2019, “Solving the problem with stannous fluoride,” Journal of the American Dental Association 150(4 Suppl.):S5-S13. [cited by applicant]
Bryan et al., 2017, “Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health”, Nitrite and Nitrate in Human Health and Disease, Humana Press pp. 21-31. [cited by applicant]
Campbell et al., 1977, “Some uses of pyrophosphates in metal finishing part II. Cobalt-tungsten alloys to zinc, including pretreatment for magnesium”, Surface Technology, Elsevier, 5(3):235-254. [cited by applicant]
International Search Report and the Written Opinion of the International Searching Authority issued in International Application PCT/US2020/026844 mailed Jul. 21, 2020. [cited by applicant]
International Search Report and the Written Opinion of the International Searching Authority issued in International Application PCT/US2021/064401 mailed May 10, 2022. [cited by applicant]
International Search Report and the Written Opinion of the International Searching Authority issued in International Application PCT/US2021/064402 mailed Apr. 20, 2022. [cited by applicant]
International Search Report and the Written Opinion of the International Searching Authority issued in International Application PCT/US2021/064587 mailed Apr. 21, 2022. [cited by applicant]
International Search Report and the Written Opinion of the International Searching Authority issued in International Application PCT/US2022/041267 mailed Dec. 15, 2022. [cited by applicant]
Kapil, et al. Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients. Hypertension. 2015; 65: 320-327. [cited by applicant]
Vanhatalo et al., 2018, “Nitrate-responsive oral microbiome modulates nitric oxide homeostatis and blood pressure in humans”, Free Radical Biology & Medicine, Elsevier, 124:21-30. [cited by applicant]
Colgate-Palmolive Company, 2022, “Gum Booster with Hyaluronic Acid Toothpaste”, Mintel Database GNPD AN: 9602562. [cited by applicant]
International Search Report and the Written Opinion of the International Searching Authority issued in International Application PCT/US2024/060971 mailed Jun. 18, 2025. [cited by applicant]