Granted Patent B2

US 12,528,857 · App. 17/733,886 · Granted Jan 20, 2026

Inventors: Stephan Hausmanns (Heidelberg, DE); Hans-Ulrich Frech (Weinheim, DE); Steffen Oesser (Glücksburg, DE); Martin Hahn (Gronau, DE); Suzane Leser (Cambridge, GB)

Assignee: GELITA AG

C07K14/78A61K8/65A61Q19/00A61K38/00

Abstract

Claims (20)

1 . A synthetic or recombinant collagen peptide comprising at least one amino acid sequence motif (glycine-X-Y) n ,

wherein X and Y for each amino acid sequence motif (glycine-X-Y) are each independently a naturally occurring amino acid,

wherein n is an integer >1,

wherein at least 80% of the amino acid sequence of the collagen peptide consists of amino acid sequence motifs (glycine-X-Y) based on the number of amino acids,

wherein at least 50% of the amino acid sequence motifs (glycine-X-Y) present in the collagen peptide contain at least one amino acid selected from the group consisting of isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, histidine, cysteine and tyrosine, and

wherein the collagen peptide contains at least 1.02% sulfur-containing amino acids, at least 0.73% histidine, at least 1.02% isoleucine, at least 2.24% leucine, at least 2.07% lysine, at least 1.1% threonine, at least 0.28% tryptophan, at least 1.91% tyrosine and/or phenylalanine, and at least 1.3% valine, in each case % by weight based on the total weight of the collagen peptide.

2 . The synthetic or recombinant collagen peptide according to claim 1 , wherein the collagen peptide comprises 10 to 30% proline, based on the total amount of amino acids of the collagen peptide.

3 . The synthetic or recombinant collagen peptide according to claim 1 , wherein the collagen peptide comprises 20 to 45% glycine, based on the total amount of amino acids of the collagen peptide.

4 . The synthetic or recombinant collagen peptide according to claim 1 , wherein X and Y for each amino acid sequence motif (glycine-X-Y) are, independently from one another, an amino acid selected from the group consisting of isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, histidine, cysteine, tyrosine and proline.

5 . The synthetic or recombinant collagen peptide according to claim 1 , comprising one of the amino acid sequences SEQ ID NO: 1 or 2.

6 . The synthetic or recombinant collagen peptide according to claim 1 , comprising an amino acid sequence according to SEQ ID NO: 3 or 4.

7 . The synthetic or recombinant collagen peptide according to claim 1 , comprising an amino acid sequence according to SEQ ID NO: 5 to 28.

8 . The synthetic or recombinant collagen peptide according to claim 1 , wherein the collagen peptide has a Protein Digestibility Corrected Amino Acid Score (PDCAAS) of at least 0.4.

9 . The synthetic or recombinant collagen peptide according to claim 1 , wherein the collagen peptide comprises at least 10% leucine, % by weight based on the total weight of the collagen peptide.

10 . The synthetic or recombinant collagen peptide according to claim 1 , wherein the collagen peptide is hydroxylated.

11 . The synthetic or recombinant collagen peptide according to claim 1 , wherein the collagen peptide is glycosylated.

12 . A method for therapeutic treatment of a human or animal subject, comprising administering to the subject the synthetic or recombinant collagen peptide according to claim 1 .

13 . A pharmaceutical composition comprising at least one collagen peptide according to claim 1 and at least one pharmaceutically acceptable additive.

14 . A food supplement or food item comprising at least one collagen peptide according to claim 1 and at least one food-acceptable additive.

15 . A cosmetic product comprising at least one collagen peptide according to claim 1 and at least one skin-friendly additive.

Assignments (1)

Priority Claims (3)

Continuity (1)

References Cited (14)