IP Library › Granted Patent US 12,531,135
Granted Patent B2
US 12,531,135 · App. 16/023,764 · Granted Jan 20, 2026

Methods of estimating gamete variation

Inventor: Claas Heuer (Heidmoor, DE)
Assignee: Inguran, LLC
G16B20/20G16B20/00G16B20/40G16B40/00
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Quick Facts
Patent No.
US 12,531,135
App. No.
16/023,764
Granted
Jan 20, 2026
Kind
B2
Abstract

The invention encompasses a method of estimating a distribution or a standard deviation of breeding values or predicted transmitting abilities of gametes from an individual using population-wide estimates of linkage disequilibrium for one or more genetic markers or genes, so as to more efficiently produce offspring having breeding values or predicted transmitting abilities that equal or exceed a desired breeding value or predicted transmitting ability.

Claims (6)

1 . A method of producing offspring from an individual in a population comprising:

estimating a distribution or a standard deviation of i) breeding values or ii) predicted transmitting abilities (PTAs) of gametes from an individual using an estimate of linkage disequilibrium for one or more genetic markers or genes;

selecting the individual for breeding based on the estimated distribution or estimated standard deviation of breeding values or PTAs of the gametes;

breeding the individual; and

producing offspring from the breeding.

2 . The method of claim 1 , wherein the step of selecting comprises selecting the individual for breeding based upon an estimated standard deviation of breeding values or PTAs of the gametes that exceeds an average standard deviation of a distribution of standard deviations of breeding values or PTAs of gametes of the population by at least one standard deviation from the average.

Assignments (2)
SECURITY INTEREST Recorded Mar 31, 2021
From: INGURAN, LLC
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 055791/0492 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2018
From: HEUER, CLAAS
To: INGURAN, LLC
Reel/Frame 046323/0603 →
Continuity (2)
Provisional Application 62527838 · Jun 30, 2017
Related Publication 20190005189A1 · Jan 3, 2019
References Cited (33)
US 7407750B2 · Blott · 2008 [cited by examiner]
US 7807361B2 · Khatib · 2010 [cited by examiner]
US 8551703B2 · Medrano · 2013 [cited by examiner]
US 20070015164A1 · Khatib · 2007 [cited by applicant]
US 20120004112A1 · Lund · 2012 [cited by applicant]
US 20160309685A1 · Genus · 2016 [cited by applicant]
CN 106779076A · 2017 [cited by applicant]
WO 2017066622A2 · 2017 [cited by applicant]
Wiggans (J. Dairy Sci, 2011, vol. 94, p. 6188-6193). [cited by examiner]
Bennewitz, J., and T.h.e. Meuwissen. “The Distribution of QTL Additive and Dominance Effects in Porcine F2 Crosses.” Journal of Animal Breeding and Genetics 127, No. 3, Jun. 1, 2010. [cited by applicant]
Qanbari, S., E. C. G. Pimentel, J. Tetens, G. Thaller, P. Lichtner, A. R. Sharifi, and H. Simianer. “The Pattern of Linkage Disequilibrium in German Holstein Cattle.” Animal Genetics 41, No. 4, Aug. 1, 2010. [cited by applicant]
Van Raden, “Efficient Methods to Compute Genomic Predictions,” Dairy Science 91, 4414-4423 2008. [cited by applicant]
Gaillard et al., “The primary structure of bovine satellite 1.715.” Nucleic Acids Res 9 , No. 22, 6069-82 Nov. 25, 1981. [cited by applicant]
Miller S A et al. “A Simple Salting out Procedure for Extracting DNA from Human Nucleated Cells”, Nucleic Acids Res., vol. 16, p. 1215, 1988. [cited by applicant]
Biase et al. “Protocol for Extraction of Genomic DNA from Swine Solid Tissues.” Genetics and Molecular Biology, 25, No. 3, 313-315 (2002). [cited by applicant]
Habier, D. et al. “The Impact of Genetic Relationship Information on Genome-Assisted Breeding Values” Genetics 177: 2389-2397 Dec. 2007. [cited by applicant]
Ma, Li.“Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.” PLoS Genet 11, No. 11. Nov. 5, 2015. [cited by applicant]
Segelke, Dierck. “Prediction of Expected Genetic Variation Within Groups of Offspring for Innovative Mating Schemes.” Genetics Selection Evolution 46, No. 42, 2014. [cited by applicant]
Fergusan et al. “Linear Programming: Fundamentals and Applications.” McGraw-Hill, 1958. [cited by applicant]
Falconer, Douglas S., and Mackay, Trudy. Introduction to Quantitative Genetics. 4th edition. Essex, England: Benjamin Cummings, 1996. [cited by applicant]
EP Extended Search Report issued on May 21, 2021 in related EP Appl. No. 18822812.6. [cited by applicant]
International Search Report and Written Opinion dated Jun. 29, 2018 issued in related PCT Appl. No. PCT/US18/40353. [cited by applicant]
Bennet Cassell: “The All-Breed Animal Model”, Virginia Cooperative Extension Publication 404-086, May 1, 2009. [cited by applicant]
Van Der Werf, EBV Accuracy. Jul. 29, 2016. [cited by applicant]
Stock et al. “Genomic Selection: Status in Different Species and Challenges for Breeding” Reprod Dom Anim 48 (Suppl. 1), 2-10 (2013). [cited by applicant]
Office Action issued in counterpart Argentinian application No. 20180101779, issued on May 31, 2024 (4 pages). [cited by applicant]
Wiggans, G. R., Cooper, T. A., VanRaden, P. M., & Cole, J. B. (2011). Technical note: Adjustment of traditional cow evaluations to improve accuracy of genomic predictions. Journal of Dairy Science, 94(12), 6188-6193. ht… [cited by applicant]
Office Action issued in counterpart European application No. 188228126, dated Jun. 5, 2024 (10 pages). [cited by applicant]
Bennet Cassell: “The All-Breed Animal Model”, Virginia Cooperative Extension Publication 404-086, May 1, 2009 (May 1, 2009), XP055555557, Retrieved from the Internet: URL:https://pubs.ext.vt.edu/content/dam/pubs_ext_vt_… [cited by applicant]
Office Action issued in counterpart Mexican application No. MX/a/2020/000137, dated Jul. 6, 2023 (4 pages). [cited by applicant]
Office Action issued in counterpart Mexican application No. MX/a/2020/000137, dated Oct. 9, 2024 (9 pages). [cited by applicant]
Office Action issued in counterpart Mexican application No. MX/a/2020/000137, dated Apr. 14, 2025 (8 pages). [cited by applicant]
Laido Giovanni et al: “Linkage Disequilibrium and Genome-Wide Association Mapping in Tetraploid Wheat ( [cited by applicant]