IP Library › Granted Patent US 12,533,366
Granted Patent B2
US 12,533,366 · App. 18/379,189 · Granted Jan 27, 2026

Low dose therapeutic treatment

Inventors: Perry Davidson (Tel-Aviv, IL); Seth Kindler (Tel-Aviv, IL); Shlomo Almog (Reut, IL); Binyamin Schwartz (Sde Eliezer, IL); Aaron Schorr (Misgav, IL); Daniella Atzmony (Modiin-Maccabim-Reut, IL)
Assignee: Syqe Medical Ltd.
A61K31/658A61K9/008A61M11/042A61M15/0003A61M15/009A61P29/02G16H20/13G16H40/63A61M2205/52
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Quick Facts
Patent No.
US 12,533,366
App. No.
18/379,189
Granted
Jan 27, 2026
Kind
B2
Abstract

Some embodiments of the invention relate to a system for delivering to a subject at least one pre-determined amount of THC, the system comprising: a memory which stores a scheduled regimen for delivery of THC to the subject, the scheduled regimen defining: a maximal amount of THC to be delivered, the amount being 0.75 mg THC or less, and a time period within which that amount is delivered, the time period being 2 hours or longer; a decision module which decides, according to the scheduled regimen, if a delivery should take place; and an inhaler device for delivering THC to the subject, the inhaler device comprising a controller which carries out delivery of THC based on the decision made by the decision module.

Claims (22)

1 . A method of clinically dispensing an active substance using an inhaler programmed with a treatment schedule, comprising:

prescribing said treatment schedule for at least one week to a patient,

allowing a patient to choose to inhale a treatment from an inhaler; and

limiting said allowing by the inhaler, according to a maximal amount of 5 mg of said active substance per 24 hours, for said at least one week, wherein said limiting comprises limiting using a plurality of sets of maximal amounts and predefined time periods.

2 . The method of claim 1 , wherein said limiting comprises limiting based on a number of allowed delivery events in a time period of said predefined time periods.

3 . The method of claim 1 , wherein said active substance comprises THC.

4 . The method of claim 1 , wherein said predefined time periods are between 2 hours and 7 hours.

5 . The method of claim 1 , wherein said maximal amount is 2 mg or less.

6 . A method of controlling a THC dispensing device for clinical dispensing to a patient, comprising:

dispensing an initial dose of THC, selected to be therapeutic for a patient; and

within a first time window of 24 hours from said initial dose, allowing dispensing of a further dose of THC to the patient, such that a total amount of said initial dose and said further dose is no more than 5 mg THC.

7 . The method of claim 6 , further comprising, within a second time window, preventing dispensing of any additional dose of THC until said second time window has ended.

8 . The method according to claim 7 , wherein said second time window is 2 hours or longer.

9 . The method according to claim 7 , wherein a total of said initial dose and said further dose is selected to be sufficient to reduce a treated symptom without return of said symptom to a pre-inhalation degree for at least as long as said second time window.

10 . The method according to claim 6 , wherein said initial dose and said further dose of THC are each dispensed over a single delivery event.

11 . The method according to claim 6 , wherein delivery of each of said initial dose and of said further dose takes place during a single inhalation of a user of the THC dispensing device.

12 . The method according to claim 6 , wherein a total number of delivery events over said 24 hour time period is 12 or less.

13 . The method according to claim 6 , wherein a total of no more than 3 mg THC are dispensed over a 24 hour time period.

14 . The method according to claim 7 , wherein at least one of said initial dose of THC, said further dose of THC and said additional dose of THC is dispensed concomitantly or sequentially with one or more other active substances.

15 . The method according to claim 6 , wherein no more than 0.75 mg THC are delivered at any given dose.

16 . The method according to claim 6 , wherein said initial dose and said further dose together are lower than a maximal dose allowed within said first time window.

17 . The method of claim 6 , wherein each of said initial dose or of said further dose comprises no more than about 2 mg of said THC.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2023
From: DAVIDSON, PERRY; KINDLER, SETH; ALMOG, SHLOMO; SCHWARTZ, BINYAMIN; SCHORR, AARON; ATZMONY, DANIELLA
To: SYQE MEDICAL LTD.
Reel/Frame 065287/0093 →
Continuity (3)
Continuation 16068373
Provisional Application 62275314 · Jan 6, 2016
Related Publication 20240050397A1 · Feb 15, 2024
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