System and method for radiation treatment planning
A computer-implemented method for radiation treatment planning, the method comprising: receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient; applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure seeks to minimize a cost function which is representative of a dose excess value above the reference dose value; and responsive to determining that the dose excess value is below a threshold value: decreasing the reference dose value; and reapplying the optimization procedure to the treatment plan, wherein the optimization procedure seeks to minimize the cost function based on the decreased reference dose value.
1 . A computer-implemented method for radiation treatment planning, the method comprising:
receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value; and
responsive to determining that the dose excess value is below a threshold value:
decreasing the reference dose value;
reapplying the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value; and
iterating the steps of decreasing the reference dose value and reapplying the optimization procedure until a stopping criterion is reached, wherein the stopping criterion comprises the optimization procedure failing to reduce the cost function such that the dose excess value is below the threshold value after a defined number of optimization iterations or a defined amount of time.
2 . The method of claim 1 , further comprising:
responsive to a determination that the stopping criterion has been reached, outputting a set of optimized parameters for the treatment plan.
3 . The method of claim 2 , wherein the set of optimized parameters define a fluence map for the treatment plan.
4 . The method of claim 2 , further comprising:
determining a configuration of a radiotherapy system for the treatment plan based on the set of optimized parameters.
5 . The method of claim 1 , wherein the optimization procedure iteratively adapts the treatment plan to minimize the cost function.
6 . The method of claim 1 , wherein the reference dose value is decreased by a fixed value.
7 . The method of claim 6 , wherein the fixed value is between 0.3 and 0.7 Gy.
8 . The method of claim 1 , wherein the reference dose value is decreased by an amount based on one or more of: the reference dose value, the threshold value, and a difference between the reference dose value and the threshold value.
9 . The method of claim 1 , wherein the dose excess value comprises a root mean square dose excess value.
10 . The method of claim 1 , wherein the cost function is a quadratic overdose cost function.
11 . The method of claim 1 , wherein the cost function is proportional to:
∑
i
∈
V
❘
"\[LeftBracketingBar]"
V
i
❘
"\[RightBracketingBar]"
[
D
i
-
Δ
]
+
2
representing a summation over i voxels in a volume V of the first region, wherein V i is a volume of the ith voxel, D i is a dose delivered to the ith voxel, Δ is the reference dose value, and the operator [D i −Δ] + represents the maximum of [D i −Δ] and zero.
12 . The method of claim 1 , wherein the method further comprises:
prior to applying the optimization procedure, receiving a maximum dose excess value, wherein the threshold value is equal to or less than the maximum dose excess value.
13 . The method of claim 12 , wherein a reference objective for the optimization procedure comprises the reference dose value and the maximum dose excess value.
14 . The method of claim 1 , wherein the optimization procedure further reduces the cost function subject to one or more constraints.
15 . The method of claim 1 , wherein the optimization procedure further reduces the cost function with respect to one or more optimizable parameters.
16 . The method of claim 15 , wherein the one or more optimizable parameters comprise one or more of: the dose excess value, one or more beamlets weights, one or more beam angles, a dose-histogram-volume information, a number of radiation beams, and a dose per beam.
17 . The method of claim 1 , wherein the first region comprises a target region for the radiation treatment and/or an organ at risk, OAR.
18 . A data processing apparatus comprising:
a memory storing computer-executable instructions; and
a processor configured to execute the instructions to:
receive a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
apply an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value; and
responsive to determining that the dose excess value is below a threshold value:
decrease the reference dose value;
reapply the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value; and
iterate the steps of decreasing the reference dose value and reapplying the optimization procedure until a stopping criterion is reached, wherein the stopping criterion comprises the optimization procedure failing to reduce the cost function such that the dose excess value is below the threshold value after a defined number of optimization iterations or a defined amount of time.
19 . A non-transitory computer-readable storage medium comprising instructions which, when executed by a computer, cause the computer to:
receive a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
apply an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value; and
responsive to determining that the dose excess value is below a threshold value:
decrease the reference dose value;
reapply the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value; and
iterating the steps of decreasing the reference dose value and reapplying the optimization procedure until a stopping criterion is reached, wherein the stopping criterion comprises the optimization procedure failing to reduce the cost function such that the dose excess value is below the threshold value after a defined number of optimization iterations or a defined amount of time.
20 . A computer-implemented method for radiation treatment planning, the method comprising:
receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value; and
responsive to determining that the dose excess value is below a threshold value:
decreasing the reference dose value;
reapplying the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value; and
iterating the steps of decreasing the reference dose value and reapplying the optimization procedure until a stopping criterion is reached, wherein the stopping criterion comprises the optimization procedure failing to reduce the cost function such that the dose excess value is below the threshold value.
21 . A computer-implemented method for radiation treatment planning, the method comprising:
receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value; and
responsive to determining that the dose excess value is below a threshold value:
decreasing the reference dose value;
reapplying the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value;
iterating the steps of decreasing the reference dose value and reapplying the optimization procedure until a stopping criterion is reached; and
responsive to a determination that the stopping criterion has been reached, outputting a set of optimized parameters for the treatment plan, wherein the set of optimized parameters define a fluence map for the treatment plan.
22 . A computer-implemented method for radiation treatment planning, the method comprising:
receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value, wherein the dose excess value comprises a root mean square dose excess value; and
responsive to determining that the dose excess value is below a threshold value:
decreasing the reference dose value; and
reapplying the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value.
23 . A computer-implemented method for radiation treatment planning, the method comprising:
receiving a reference dose value, wherein the reference dose value is a defined maximum radiation dose within a first region for radiation treatment in a patient;
applying an optimization procedure to a treatment plan for radiation treatment of the patient, wherein the optimization procedure reduces a cost function which is representative of a dose excess value above the reference dose value, wherein the cost function is a quadratic overdose cost function; and
responsive to determining that the dose excess value is below a threshold value:
decreasing the reference dose value; and
reapplying the optimization procedure to the treatment plan, wherein the optimization procedure further reduces the cost function based on the decreased reference dose value.