Systems and methods for injection and aspiration
A system for catheter-based aspiration includes an aspiration catheter having a distal portion configured for insertion within a blood vessel of a subject, the aspiration catheter including an aspiration lumen having a distal opening at the distal portion of the aspiration catheter, an injection lumen having a distal end at the distal portion of the aspiration catheter, and an orifice located at or near the distal end of the injection lumen, the orifice configured to direct liquid into the aspiration lumen at or near the distal opening of the aspiration lumen; an injector configured to pressurize the liquid within the injection lumen, such that liquid exits the orifice and enters the aspiration lumen; and a mechanical oscillator coupled to the injector and configured to cause a pulsatile pressure of the liquid as it is injected through the injection lumen.
1 . A method for catheter-based aspiration, comprising:
providing a catheter having a distal portion configured for insertion within a blood vessel of a subject, the catheter comprising:
a first lumen having a distal opening at the distal portion of the catheter;
a second lumen having a distal end at the distal portion of the catheter; and
an orifice located at or near the distal end of the second lumen, the orifice configured to direct liquid into the first lumen at or near the distal opening of the first lumen; and
actuating an injector in a non-uniform manner to cause a pulsatile pressure of a liquid in the second lumen as the liquid is injected through the second lumen, wherein actuating the injector in a non-uniform manner comprises automatically injecting in an oscillating or variable manner to repeatedly displace a plunger in an interior of a barrel in a first direction along a longitudinal displacement axis by an increment, followed by movement of the plunger in a second direction, opposite the first direction.
2 . The method of claim 1 , wherein movement of the plunger in the second direction corresponds to recoil of the injector following displacement thereof.
3 . The method of claim 2 , wherein the recoil is a controlled recoil corresponding to a predetermined amount of movement in the second direction.
4 . The method of claim 1 , wherein movement of the plunger in the second direction corresponds to controlled mechanical slip within an actuator.
5 . The method of claim 1 , wherein repeatedly displacing the plunger comprises displacing the plunger at a frequency of between 1 Hz and 8 Hz.
6 . The method of claim 1 , further comprising reducing a pressure of the liquid in the second lumen to bring or maintain the pressure of the liquid below an injection pressure threshold.
7 . The method of claim 6 , wherein reducing the pressure of the liquid in the second lumen comprises actuating a valve in pressure communication with the second lumen.
8 . The method of claim 1 , further comprising utilizing a mechanical oscillator coupled to the injector to at least partially cause the pulsatile pressure of the liquid, the mechanical oscillator comprising a first member and a second member axially arrayed with respect to each other and configured such that changes in a relative rotational orientation between the first member and the second member cause reciprocal relative axial displacement between the first member and the second member, and wherein the first member is coupled to the plunger and configured to transfer motive force thereto along the longitudinal displacement axis.