Quinazoline compound
A quinazoline compound and a pharmaceutically acceptable salt thereof, in particular a compound of formula (II) and a pharmaceutically acceptable salt thereof.
1 . A compound represented by formula (II) or a pharmaceutically acceptable salt thereof,
wherein,
ring A is selected from phenyl and thienyl;
R 1 is selected from H and NH 2 ;
R 2 is selected from C 1-3 alkyl, and the C 1-3 alkyl is optionally substituted by 1, 2, 3, 4 or 5 R a ;
R 3 is selected from H and F;
R 4 is selected from
and the
are each independently optionally substituted by 1, 2, 3 or 4 R b ;
R 5 is selected from H, Cl and CH 3 ;
R a is each independently selected from D, F, Cl, Br, I, OH, CN, NH 2 , CH 3 , —CH 2 NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —OCH 3 , —COOH, —COOCH 3 and cyclopropyl;
R b is each independently selected from H, F, Cl, Br, I, OH, CN, NH 2 , C 1-3 alkyl, —CH 2 NH 2 , —NHCH 3 , —N(CH 3 ) 2 , C 1-3 alkoxy, —COOH, —COO—C 1-3 alkyl, —C(═O)—C 1-3 alkyl, —S(═O) 2 -C 1-3 alkyl and cyclopropyl, and the C 1-3 alkyl, C 1-3 alkoxy and cyclopropyl are each independently optionally substituted by 1, 2, or 3 R;
R is each independently selected from F, Cl, Br, I, OH, CN, NH 2 , —OCH 3 and —COOH.
2 . The compound as claimed in claim 1 or the pharmaceutically acceptable salt thereof, wherein, R 1 is selected from NH 2 .
3 . The compound as claimed in claim 1 or the pharmaceutically acceptable salt thereof, wherein, R 2 is selected from CF 3 , CHF 2 ,
4 . The compound as claimed in claim 1 or the pharmaceutically acceptable salt thereof, wherein, Rb is each independently selected from H, F, Cl, Br, I, OH, CN, NH 2 , CH 3 , —CH 2 F, —CHF 2 , —CH 2 CN, —CH 2 OH, —CH 2 OCH 3 , —CH 2 CH 3 , —CH 2 NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —OCH 3 , —COOH, —COOCH 3 ,
5 . The compound as claimed in claim 1 or the pharmaceutically acceptable salt thereof, wherein, R 4 is selected from
6 . The compound as claimed in claim 1 or the pharmaceutically acceptable salt thereof, wherein, the compound is selected from
7 . The compound as claimed in claim 6 or the pharmaceutically acceptable salt thereof, wherein, the compound is selected from
8 . A compound or a pharmaceutically acceptable salt thereof, wherein, the compound is selected from
9 . The compound as claimed in claim 8 or the pharmaceutically acceptable salt thereof, wherein, the compound is selected from
10 . A method for the treatment of lung cancer, pancreatic cancer or rectal cancer in a subject in need thereof, comprising: administering the compound as claimed in claim 1 or the pharmaceutically acceptable salt thereof to the subject.