IP Library › Granted Patent US 12,558,307
Granted Patent B2
US 12,558,307 · App. 13/382,442 · Granted Feb 24, 2026

Insulin preparations containing methionine

Inventors: Isabell Schoettle (Frankfurt am Main, DE); Annika Hagendorf (Frankfurt am Main, DE); Christiane Fuerst (Frankfurt am Main, DE); Gerrit Hauck (Frankfurt am Main, DE); Verena Siefke-Henzler (Frankfurt am Main, DE); Walter Kamm (Frankfurt am Main, DE); Julia Schnieders (Frankfurt am Main, DE)
Assignee: SANOFI-AVENTIS
A61K9/0019A61K9/10A61K38/2278A61K38/28A61K47/00A61K47/183A61K47/20C07K14/62A61K47/10
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,558,307
App. No.
13/382,442
Granted
Feb 24, 2026
Kind
B2
Abstract

The invention relates to an aqueous pharmaceutical formulation having insulin, an insulin analog, or an insulin derivative, and methionine; and to the production thereof, to the use thereof for treating diabetes mellitus, and to a medication for treating diabetes mellitus.

Claims (5)

1 . An aqueous liquid pharmaceutical formulation comprising about 240 to 3000 nmol/ml Gly(A21), Arg(B31), Arg(B32) human insulin, about 0.089 to about 3.0 mg/ml of methionine as an antioxidative stabilizer, about 0.01 to about 0.08 mg/mL of zinc, about 1.0 to about 3.0 mg/ml of m-cresol, and about 20 mg to 30 mg/ml of glycerol, wherein the liquid pharmaceutical formulation has a pH of 2.5 to 4.5, wherein the formulation is a storable solution.

2 . The aqueous liquid pharmaceutical formulation of claim 1 , wherein the glycerol concentration is 25 mg/ml.

3 . The aqueous liquid pharmaceutical formulation of claim 1 , wherein the m-cresol concentration is 2 mg/ml.

4 . The aqueous liquid pharmaceutical formulation of claim 1 , wherein the concentration of the Gly(A21), Arg(B31), Arg(B32) human insulin is about 100 U/ml.

5 . The aqueous liquid pharmaceutical formulation of claim 1 ; wherein the storable solution is administered via injection.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2012
From: SCHOETTLE, ISABELL; HAGENDORF, ANNIKA; FUERST, CHRISTIANE; HAUCK, GERRIT; SIEFKE-HENZLER, VERENA; KAMM, WALTER; SCHNIEDERS, JULIA
To: SANOFI-AVENTIS DEUTSCHLAND GMBH
Reel/Frame 027902/0136 →
Priority Claims (2)
DE 102009031748.1 · Jul 6, 2009 · national
DE 102010013134.2 · Mar 27, 2010 · national
Continuity (2)
Provisional Application 61264356 · Nov 25, 2009
Related Publication 20120252724A1 · Oct 4, 2012
References Cited (400)
US 3758683A · Jackson · 1973 [cited by applicant]
US 3868358A · Jackson · 1975 [cited by applicant]
US 4153689A · Hirai et al. · 1979 [cited by applicant]
US 4165370A · Coval · 1979 [cited by applicant]
US 4258134A · Yoshida et al. · 1981 [cited by examiner]
US 4367737A · Kozam et al. · 1983 [cited by applicant]
US 4608364A · Grau · 1986 [cited by applicant]
US 4614730A · Hansen · 1986 [cited by applicant]
US 4644057A · Bicker et al. · 1987 [cited by applicant]
US 4689042A · Sarnoff et al. · 1987 [cited by applicant]
US 4701440A · Grau · 1987 [cited by applicant]
US 4731405A · Kirsch et al. · 1988 [cited by applicant]
US 4783441A · Thurow · 1988 [cited by applicant]
US 4839341A · Massey et al. · 1989 [cited by applicant]
US 4885164A · Thurow · 1989 [cited by applicant]
US 4959351A · Grau · 1990 [cited by applicant]
US 4960702A · Rice et al. · 1990 [cited by applicant]
US 4994439A · Longenecker et al. · 1991 [cited by applicant]
US 5008241A · Markussen et al. · 1991 [cited by applicant]
US 5034415A · Rubin · 1991 [cited by applicant]
US 5070186A · Joergensen · 1991 [cited by applicant]
US 5101013A · Dorschug et al. · 1992 [cited by applicant]
US 5149716A · Vertesy et al. · 1992 [cited by applicant]
US 5177058A · Dorschug · 1993 [cited by applicant]
US 5227293A · Stengelin et al. · 1993 [cited by applicant]
US 5253785A · Haber et al. · 1993 [cited by applicant]
US 5272135A · Takruri · 1993 [cited by applicant]
US 5358708A · Patel · 1994 [cited by applicant]
US 5358857A · Stengelin et al. · 1994 [cited by applicant]
US 5370629A · Michel et al. · 1994 [cited by applicant]
US 5397771A · Bechgaard et al. · 1995 [cited by applicant]
US 5407609A · Tice et al. · 1995 [cited by applicant]
US 5424286A · Eng · 1995 [cited by applicant]
US 5428006A · Bechgaard et al. · 1995 [cited by applicant]
US 5473049A · Obermeier et al. · 1995 [cited by applicant]
US 5474978A · Bakaysa et al. · 1995 [cited by applicant]
US 5478323A · Westwood et al. · 1995 [cited by applicant]
US 5496924A · Habermann et al. · 1996 [cited by applicant]
US 5506203A · Backstrom et al. · 1996 [cited by applicant]
US 5509905A · Michel · 1996 [cited by applicant]
US 5514646A · Chance et al. · 1996 [cited by applicant]
US 5524286A · Chiesa et al. · 1996 [cited by applicant]
US 5534488A · Hoffman · 1996 [cited by applicant]
US 5545618A · Buckley et al. · 1996 [cited by applicant]
US 5547929A · Anderson, Jr. et al. · 1996 [cited by applicant]
US 5559094A · Brems et al. · 1996 [cited by applicant]
US 5597796A · Brange · 1997 [cited by applicant]
US 5614219A · Wunderlich et al. · 1997 [cited by applicant]
US 5614492A · Habener · 1997 [cited by applicant]
US 5631224A · Efendic et al. · 1997 [cited by applicant]
US 5654008A · Herbert et al. · 1997 [cited by applicant]
US 5656722A · Dorschug · 1997 [cited by applicant]
US 5663291A · Obermeier et al. · 1997 [cited by applicant]
US 5670260A · Thorens · 1997 [cited by applicant]
US 5670360A · Thorens · 1997 [cited by applicant]
US 5674204A · Chanoch · 1997 [cited by applicant]
US 5693608A · Bechgaard et al. · 1997 [cited by applicant]
US 5700662A · Chance et al. · 1997 [cited by applicant]
US 5707641A · Gertner et al. · 1998 [cited by applicant]
US 5783556A · Clark et al. · 1998 [cited by applicant]
US 5824638A · Burnside et al. · 1998 [cited by applicant]
US 5846747A · Thorens et al. · 1998 [cited by applicant]
US 5846937A · Drucker · 1998 [cited by applicant]
US 5866538A · Norup et al. · 1999 [cited by applicant]
US 5879584A · Bianchetti et al. · 1999 [cited by applicant]
US 5935566A · Yuen et al. · 1999 [cited by applicant]
US 5948751A · Kimer et al. · 1999 [cited by applicant]
US 5952297A · De Felippis et al. · 1999 [cited by applicant]
US 5985309A · Edwards et al. · 1999 [cited by applicant]
US 6006753A · Efendic · 1999 [cited by applicant]
US 6034054A · DeFelippis et al. · 2000 [cited by applicant]
US 6043214A · Jensen et al. · 2000 [cited by applicant]
US 6051551A · Hughes et al. · 2000 [cited by applicant]
US 6051689A · Thorens · 2000 [cited by applicant]
US 6100376A · Doerschug · 2000 [cited by applicant]
US 6110703A · Egei-Mitani et al. · 2000 [cited by applicant]
US 6174856B1 · Langballe · 2001 [cited by examiner]
US 6191102B1 · DiMarchi et al. · 2001 [cited by applicant]
US 6211144B1 · Havelund · 2001 [cited by applicant]
US 6227819B1 · Gettel et al. · 2001 [cited by applicant]
US 6235004B1 · Steenfeldt-Jensen et al. · 2001 [cited by applicant]
US 6248095B1 · Giambattista et al. · 2001 [cited by applicant]
US 6248363B1 · Patel et al. · 2001 [cited by applicant]
US 6265335B1 · Oleske et al. · 2001 [cited by applicant]
US 6267981B1 · Okamoto et al. · 2001 [cited by applicant]
US 6268335B1 · Brader · 2001 [cited by applicant]
US 6268343B1 · Knudsen et al. · 2001 [cited by applicant]
US 6271241B1 · DeSimone et al. · 2001 [cited by applicant]
US 6284725B1 · Coolidge et al. · 2001 [cited by applicant]
US 6309663B1 · Patel et al. · 2001 [cited by applicant]
US 6310038B1 · Havelund · 2001 [cited by applicant]
US 6329336B1 · Briden et al. · 2001 [cited by applicant]
US 6335316B1 · Hughes et al. · 2002 [cited by applicant]
US 6344180B1 · Holst et al. · 2002 [cited by applicant]
US 6358924B1 · Hoffmann · 2002 [cited by applicant]
US 6384016B1 · Kaarsholm · 2002 [cited by applicant]
US 6388053B1 · Galloway et al. · 2002 [cited by applicant]
US 6395767B2 · Robl et al. · 2002 [cited by applicant]
US 6410508B1 · Isales et al. · 2002 [cited by applicant]
US 6410511B2 · L'Italien et al. · 2002 [cited by applicant]
US 6444641B1 · Flora · 2002 [cited by applicant]
US 6468959B1 · Wunderlich et al. · 2002 [cited by applicant]
US 6489292B1 · Havelund et al. · 2002 [cited by applicant]
US 6528486B1 · Larsen et al. · 2003 [cited by applicant]
US 6734162B2 · Van Antwerp et al. · 2004 [cited by applicant]
US 6737401B2 · Kim et al. · 2004 [cited by applicant]
US 6767887B1 · Hoffmann et al. · 2004 [cited by applicant]
US 6818738B2 · Havelund · 2004 [cited by applicant]
US 6852694B2 · Van Antwerp et al. · 2005 [cited by examiner]
US 6875589B1 · Dorschug et al. · 2005 [cited by applicant]
US 6902744B1 · Kolterman et al. · 2005 [cited by applicant]
US 6908610B1 · Sato · 2005 [cited by applicant]
US 6908897B2 · Brandenburg et al. · 2005 [cited by applicant]
US 6960561B2 · Boderke · 2005 [cited by applicant]
US 7022674B2 · DeFelippis · 2006 [cited by applicant]
US 7115563B2 · Younis · 2006 [cited by applicant]
US 7119086B2 · Di Malta et al. · 2006 [cited by applicant]
US 7192919B2 · Tzannis et al. · 2007 [cited by applicant]
US 7205276B2 · Boderke · 2007 [cited by applicant]
US 7205277B2 · Boderke · 2007 [cited by examiner]
US 7238663B2 · DeFelippis et al. · 2007 [cited by applicant]
US 7405196B2 · Rosskamp et al. · 2008 [cited by applicant]
US 7476652B2 · Brunner-Schwarz et al. · 2009 [cited by applicant]
US 7544656B2 · Sabetsky · 2009 [cited by applicant]
US 7544657B2 · Ebbehoj et al. · 2009 [cited by applicant]
US 7713930B2 · Brunner-Schwarz et al. · 2010 [cited by examiner]
US 7803763B2 · Thurow et al. · 2010 [cited by applicant]
US 7807242B2 · Soerensen et al. · 2010 [cited by applicant]
US 7918833B2 · Veasey et al. · 2011 [cited by applicant]
US 7939293B2 · Habermann et al. · 2011 [cited by applicant]
US 7977310B2 · Rosskamp et al. · 2011 [cited by applicant]
US 8048854B2 · Habermann et al. · 2011 [cited by examiner]
US 8084420B2 · Steiner et al. · 2011 [cited by applicant]
US 8092421B2 · Seiferlein et al. · 2012 [cited by applicant]
US 8092422B2 · Seiferlein et al. · 2012 [cited by applicant]
US 8178495B2 · Chilkoti · 2012 [cited by applicant]
US 8574214B2 · Kuhn et al. · 2013 [cited by applicant]
US 8633156B2 · Habermann et al. · 2014 [cited by applicant]
US 9345750B2 · Becker et al. · 2016 [cited by applicant]
US 10029011B2 · Hagendorf · 2018 [cited by examiner]
US 20010012829A1 · Anderson et al. · 2001 [cited by applicant]
US 20010033868A1 · Rossling et al. · 2001 [cited by applicant]
US 20010039260A1 · Havelund · 2001 [cited by applicant]
US 20010047084A1 · Knudsen et al. · 2001 [cited by applicant]
US 20020107265A1 · Chen et al. · 2002 [cited by applicant]
US 20020132760A1 · Van Antwerp et al. · 2002 [cited by applicant]
US 20020198140A1 · Havelund · 2002 [cited by applicant]
US 20030004096A1 · Boderke · 2003 [cited by applicant]
US 20030026872A1 · Dake et al. · 2003 [cited by applicant]
US 20030212248A1 · Furman · 2003 [cited by applicant]
US 20040022792A1 · Klinke · 2004 [cited by applicant]
US 20040037893A1 · Hansen · 2004 [cited by examiner]
US 20040048783A1 · Brunner-Schwarz et al. · 2004 [cited by applicant]
US 20040097410A1 · Zheng et al. · 2004 [cited by applicant]
US 20040106547A1 · Larsen et al. · 2004 [cited by applicant]
US 20040235710A1 · DeFelippis et al. · 2004 [cited by applicant]
US 20050014679A1 · Beals et al. · 2005 [cited by applicant]
US 20050106147A1 · Jordan et al. · 2005 [cited by applicant]
US 20050171009A1 · Brunner-Schwarz et al. · 2005 [cited by applicant]
US 20060004049A1 · Yao et al. · 2006 [cited by applicant]
US 20060014678A1 · Cowley et al. · 2006 [cited by applicant]
US 20060019347A1 · Cho et al. · 2006 [cited by applicant]
US 20060073213A1 · Hotamisligil et al. · 2006 [cited by applicant]
US 20060093576A1 · Chen et al. · 2006 [cited by applicant]
US 20060120969A1 · Nilsson et al. · 2006 [cited by applicant]
US 20060194719A1 · Ebbehoj et al. · 2006 [cited by applicant]
US 20060287221A1 · Knudsen et al. · 2006 [cited by applicant]
US 20070111940A1 · Larsen et al. · 2007 [cited by applicant]
US 20070128193A1 · O'Neil et al. · 2007 [cited by applicant]
US 20070135338A1 · O'Neil et al. · 2007 [cited by applicant]
US 20070155653A1 · Boderke · 2007 [cited by applicant]
US 20070191271A1 · Mayhew et al. · 2007 [cited by examiner]
US 20070237827A1 · Sung et al. · 2007 [cited by applicant]
US 20080064856A1 · Warne · 2008 [cited by examiner]
US 20080146490A1 · Joabsson et al. · 2008 [cited by applicant]
US 20080248999A1 · Steiner · 2008 [cited by examiner]
US 20080260840A1 · Alessi et al. · 2008 [cited by examiner]
US 20080267907A1 · Poulsen · 2008 [cited by applicant]
US 20090082255A1 · Brunner-Schwarz et al. · 2009 [cited by examiner]
US 20090088369A1 · Steiness · 2009 [cited by applicant]
US 20090099064A1 · Lougheed · 2009 [cited by applicant]
US 20090142338A1 · Levetan · 2009 [cited by applicant]
US 20090175840A1 · Kashyap et al. · 2009 [cited by applicant]
US 20090176692A1 · Larsen et al. · 2009 [cited by applicant]
US 20090186807A1 · Boderke et al. · 2009 [cited by applicant]
US 20090186819A1 · Carrier et al. · 2009 [cited by applicant]
US 20090208565A1 · Ebbehoj et al. · 2009 [cited by applicant]
US 20090214468A1 · Lin · 2009 [cited by examiner]
US 20090214657A1 · Qazi · 2009 [cited by applicant]
US 20090304665A1 · Frost et al. · 2009 [cited by examiner]
US 20090312236A1 · Beals et al. · 2009 [cited by applicant]
US 20090324701A1 · Williams · 2009 [cited by applicant]
US 20100029558A1 · Bristow · 2010 [cited by applicant]
US 20100055049A1 · Kuo et al. · 2010 [cited by applicant]
US 20100057194A1 · Ryan · 2010 [cited by applicant]
US 20100069292A1 · Pohl et al. · 2010 [cited by applicant]
US 20100069293A1 · Bolotin et al. · 2010 [cited by applicant]
US 20100227816A1 · Fiatt et al. · 2010 [cited by applicant]
US 20100279931A1 · Garibay et al. · 2010 [cited by applicant]
US 20100311112A1 · Rissom et al. · 2010 [cited by applicant]
US 20110020294A1 · Hammerman · 2011 [cited by applicant]
US 20110021423A1 · Olsen et al. · 2011 [cited by applicant]
US 20110077197A1 · Habermann et al. · 2011 [cited by examiner]
US 20110118178A1 · Silvestre et al. · 2011 [cited by applicant]
US 20110118180A1 · Silverstre et al. · 2011 [cited by applicant]
US 20110144008A1 · Larsen et al. · 2011 [cited by applicant]
US 20110152185A1 · Plum et al. · 2011 [cited by applicant]
US 20110173722A1 · Habermann et al. · 2011 [cited by applicant]
US 20110230402A1 · Johansen et al. · 2011 [cited by applicant]
US 20110236925A1 · Hazra et al. · 2011 [cited by applicant]
US 20110245165A1 · Larsen et al. · 2011 [cited by applicant]
US 20110281790A1 · Pohl et al. · 2011 [cited by applicant]
US 20110301081A1 · Becker et al. · 2011 [cited by applicant]
US 20120021978A1 · Werner et al. · 2012 [cited by examiner]
US 20120121611A1 · Lodie et al. · 2012 [cited by applicant]
US 20120122774A1 · Becker et al. · 2012 [cited by applicant]
US 20120183616A1 · Sprogoe et al. · 2012 [cited by applicant]
US 20120184489A1 · Rau et al. · 2012 [cited by applicant]
US 20120232002A1 · Schoettle et al. · 2012 [cited by examiner]
US 20120241356A1 · Pfenninger et al. · 2012 [cited by applicant]
US 20120252724A1 · Schoettle et al. · 2012 [cited by applicant]
US 20120277147A1 · Boka et al. · 2012 [cited by applicant]
US 20120283179A1 · Brunner-Schwarz et al. · 2012 [cited by examiner]
US 20120295846A1 · Hagendorf et al. · 2012 [cited by examiner]
US 20120316108A1 · Chen et al. · 2012 [cited by applicant]
US 20130005649A1 · Niemoeller et al. · 2013 [cited by applicant]
US 20130011378A1 · Yang et al. · 2013 [cited by applicant]
US 20130012422A1 · Rosskamp et al. · 2013 [cited by applicant]
US 20130023467A1 · Silvestre et al. · 2013 [cited by applicant]
US 20130040878A1 · Silvestre et al. · 2013 [cited by applicant]
US 20130065828A1 · Ruus et al. · 2013 [cited by applicant]
US 20130079279A1 · Becker et al. · 2013 [cited by applicant]
US 20130085102A1 · Silvestre et al. · 2013 [cited by applicant]
US 20130096059A1 · Stechl et al. · 2013 [cited by applicant]
US 20130096060A1 · Stechl et al. · 2013 [cited by applicant]
US 20130203666A1 · Niemoeller et al. · 2013 [cited by applicant]
US 20130284912A1 · Vogel et al. · 2013 [cited by applicant]
US 20130296236A1 · Silvestre et al. · 2013 [cited by applicant]
US 20140024582A1 · Yang et al. · 2014 [cited by applicant]
US 20140142034A1 · Soula et al. · 2014 [cited by applicant]
US 20140148384A1 · Boka et al. · 2014 [cited by applicant]
US 20140206611A1 · Becker et al. · 2014 [cited by examiner]
US 20140248365A1 · Rademacher et al. · 2014 [cited by applicant]
US 20150119323A1 · Loos et al. · 2015 [cited by applicant]
US 20150190475A1 · Bley et al. · 2015 [cited by applicant]
US 20180036411A1 · Loos · 2018 [cited by examiner]
US 20200188516A1 · Hagendorf · 2020 [cited by examiner]
US 20210038514A1 · Brunner-Schwarz · 2021 [cited by examiner]
US 20220133890A1 · Hagendorf · 2022 [cited by examiner]
US 20230028647A1 · Brunner-Schwarz · 2023 [cited by examiner]
AU 6206686 · 1987 [cited by applicant]
AU 198775916 · 1988 [cited by applicant]
AU 200072263 · 2001 [cited by applicant]
CA 1173388 · 1984 [cited by applicant]
CA 1258427 · 1989 [cited by applicant]
CA 1336329 · 1995 [cited by applicant]
CA 1341203 · 2001 [cited by applicant]
CN 1276731 · 2000 [cited by applicant]
CN 1630709 · 2005 [cited by applicant]
CN 1662252 · 2005 [cited by applicant]
CN 101366692 · 2009 [cited by applicant]
CN 101444618 · 2009 [cited by applicant]
CN 101454019 · 2009 [cited by applicant]
CN 101670096 · 2010 [cited by applicant]
DE 2219635 · 1972 [cited by applicant]
DE 3240177 · 1983 [cited by applicant]
DE 19637230 · 1998 [cited by applicant]
DE 102008003566 · 2009 [cited by applicant]
DE 102008003568 · 2009 [cited by applicant]
DE 102008053048 · 2010 [cited by applicant]
EA 006019 · 2005 [cited by applicant]
EP 0018609 · 1980 [cited by applicant]
EP 0046979 · 1982 [cited by applicant]
EP 0124826 · 1984 [cited by applicant]
EP 0132769 · 1985 [cited by applicant]
EP 0140084 · 1985 [cited by applicant]
EP 0166529A1 · 1986 [cited by applicant]
EP 0194864 · 1986 [cited by applicant]
EP 0180920 · 1986 [cited by applicant]
EP 0200383 · 1986 [cited by applicant]
EP 0211299 · 1987 [cited by applicant]
EP 0214823 · 1987 [cited by applicant]
EP 0214826A2 · 1987 [cited by applicant]
EP 0214826B1 · 1987 [cited by applicant]
EP 0224885A1 · 1987 [cited by applicant]
EP 0227938 · 1987 [cited by applicant]
EP 0229956 · 1987 [cited by applicant]
EP 0229998 · 1987 [cited by applicant]
EP 0254516 · 1988 [cited by applicant]
EP 0305760 · 1989 [cited by applicant]
EP 0419504 · 1989 [cited by applicant]
EP 0368187 · 1990 [cited by applicant]
EP 0375437 · 1990 [cited by applicant]
EP 0375437B1 · 1990 [cited by applicant]
EP 0383472 · 1990 [cited by applicant]
EP 0294851 · 1990 [cited by applicant]
EP 0600372 · 1994 [cited by applicant]
EP 0668282 · 1995 [cited by applicant]
EP 0668292 · 1995 [cited by applicant]
EP 0678522 · 1995 [cited by applicant]
EP 0678522A1 · 1995 [cited by applicant]
EP 0376156 · 1996 [cited by applicant]
EP 0837072 · 1998 [cited by applicant]
EP 0845265 · 1998 [cited by applicant]
EP 0885961 · 1998 [cited by applicant]
EP 1076066 · 2001 [cited by applicant]
EP 1172114 · 2002 [cited by applicant]
EP 1222207 · 2002 [cited by applicant]
EP 1364032 · 2003 [cited by applicant]
EP 1523993 · 2005 [cited by applicant]
EP 1197221 · 2006 [cited by applicant]
EP 1906991 · 2008 [cited by applicant]
EP 2187950 · 2010 [cited by applicant]
EP 2389945 · 2011 [cited by applicant]
EP 2329848 · 2012 [cited by applicant]
EP 2387989 · 2014 [cited by applicant]
FR 2456522 · 1980 [cited by applicant]
GB 1527605 · 1978 [cited by applicant]
GB 1554157 · 1979 [cited by applicant]
JP 61212598 · 1986 [cited by applicant]
JP 6399096 · 1988 [cited by applicant]
JP 2218696 · 1990 [cited by applicant]
JP 2264798 · 1990 [cited by applicant]
JP 3504240 · 1991 [cited by applicant]
JP 6506444 · 1994 [cited by applicant]
JP 2001521004 · 2001 [cited by applicant]
JP 2002516880A · 2002 [cited by applicant]
JP 2005508895 · 2005 [cited by applicant]
JP 2005532365 · 2005 [cited by applicant]
JP 2006137678 · 2006 [cited by applicant]
JP 2006515267 · 2006 [cited by applicant]
JP 2007204498A1 · 2007 [cited by applicant]
JP 200991363A · 2009 [cited by applicant]
JP 2012505852 · 2012 [cited by applicant]
JP 2012255040 · 2012 [cited by applicant]
RU 2008116057 · 2009 [cited by applicant]
TW 157005 · 1991 [cited by applicant]
TW 562806 · 2003 [cited by applicant]
WO WO8300288 · 1983 [cited by applicant]
WO 8806599 · 1988 [cited by applicant]
WO WO8910937 · 1989 [cited by applicant]
WO 9007522 · 1990 [cited by applicant]
WO 9011299 · 1990 [cited by applicant]
WO 9103550 · 1991 [cited by applicant]
WO 9116929 · 1991 [cited by applicant]
WO WO9200321 · 1992 [cited by applicant]
WO 9212999 · 1992 [cited by applicant]
WO 1993018786 · 1993 [cited by applicant]
WO 9414461 · 1994 [cited by applicant]
WO 1995024183 · 1995 [cited by applicant]
WO 9604307 · 1996 [cited by applicant]
WO 9607399 · 1996 [cited by applicant]
WO 9611706 · 1996 [cited by applicant]
WO WO9632414 · 1996 [cited by applicant]
WO 9634882 · 1996 [cited by applicant]
WO 9641606 · 1996 [cited by applicant]
WO 9701331 · 1997 [cited by applicant]
WO 9748413 · 1997 [cited by applicant]
WO 1998005351 · 1998 [cited by applicant]
WO 1998008531 · 1998 [cited by applicant]
WO 1998008873 · 1998 [cited by applicant]
WO 9808871 · 1998 [cited by applicant]
WO 1998019698 · 1998 [cited by applicant]
WO 1998030231 · 1998 [cited by applicant]
WO 1998035033 · 1998 [cited by applicant]
WO 1998039022 · 1998 [cited by applicant]
WO 9842749 · 1998 [cited by applicant]
WO 9856406 · 1998 [cited by applicant]
WO WO9856418 · 1998 [cited by applicant]
WO 1999007404 · 1999 [cited by applicant]
WO 9924071 · 1999 [cited by applicant]
WO 1999021573 · 1999 [cited by applicant]
WO 1999025727 · 1999 [cited by applicant]
WO 1999025728 · 1999 [cited by applicant]
WO 1999040788 · 1999 [cited by applicant]
WO 1999043708 · 1999 [cited by applicant]
WO 1999046283 · 1999 [cited by applicant]
WO 1999062558A1 · 1999 [cited by applicant]
WO WO9962558 · 1999 [cited by applicant]
WO 0023098 · 2000 [cited by applicant]
WO 0023099 · 2000 [cited by applicant]
WO 0029013 · 2000 [cited by applicant]
WO WO00051629 · 2000 [cited by applicant]
WO 2000066629 · 2000 [cited by applicant]
WO 2000072582 · 2000 [cited by applicant]
WO 0074736A1 · 2000 [cited by applicant]
WO WO0102039 · 2001 [cited by applicant]
WO WO0104156A1 · 2001 [cited by examiner]
WO 0112155 · 2001 [cited by applicant]
WO 0121154 · 2001 [cited by applicant]
WO 0100223 · 2001 [cited by applicant]
WO 0128555 · 2001 [cited by applicant]
WO WO0124814 · 2001 [cited by applicant]
WO WO0125278A1 · 2001 [cited by applicant]
WO 0137808 · 2001 [cited by applicant]
WO 0143762 · 2001 [cited by applicant]
WO 0152937 · 2001 [cited by applicant]
WO 2001051071 · 2001 [cited by applicant]
WO 0193837 · 2001 [cited by applicant]
WO 02000243 · 2002 [cited by applicant]