Granted Patent
B2
US 12,558,396 · App. 17/599,118 · Granted Feb 24, 2026
Use of cyclo(His-Pro) (CHP) for preventing, alleviating or treating peritoneal fibrosis
Inventors:
Hoe Yune Jung (Pohang-si, KR); Do Hyun Lee (Pohang-si, KR); Heon Jong Lee (Incheon, KR); Yon Su Kim (Seoul, KR); Seung Hee Yang (Seoul, KR)
Assignees:
NOVMETAPHARMA CO., LTD.; SEOUL NATIONAL UNIVERSITY HOSPITAL; SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
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Abstract
A cyclo(His-Pro)(CHP) is useful for preventing, alleviating or treating peritoneal fibrosis. A pharmaceutical composition for preventing or treating peritoneal fibrosis, a dietary supplement composition for preventing or alleviating peritoneal fibrosis, and a peritoneal dialysis solution, which all contain CHP is disclosed. Also disclosed are a method for preventing or treating peritoneal fibrosis by using CHP, a peritoneal dialysis method using CHP, a use of CHP during the preparation of a pharmaceutical composition for preventing or treating peritoneal fibrosis, and/or a use of CHP in the preparation of a peritoneal dialysis solution.
Claims (8)
1 . A method for preventing or treating peritoneal fibrosis in a subject in need thereof, comprising administering an effective amount of cyclo(His-Pro) or a pharmaceutically acceptable salt thereof to the subject.
2 . The method of claim 1 , wherein the peritoneal fibrosis includes any one or more selected from the group consisting of retroperitoneal fibrosis and encapsulating peritoneal sclerosis.
3 . The method of claim 1 , wherein the cyclo(His-Pro) or the pharmaceutically acceptable salt thereof exhibits any one or more effect selected from the group consisting of inhibition of peritoneal epithelial-to-mesenchymal transition (EMT), inhibition of peritoneal apoptosis and inhibition of immune cell infiltration into the peritoneum.
4 . The method of claim 1 , wherein the peritoneal fibrosis is caused by dialysis.
5 . The method of claim 1 , wherein the cyclo(His-Pro) or the pharmaceutically acceptable salt thereof is administered orally or parenterally.
6 . The method of claim 1 , wherein the cyclo(His-Pro) or the pharmaceutically acceptable salt thereof is administered intravenously, intramuscularly, intraarterially, intrathecally, transdermally, subcutaneously, intraperitoneally, intranasally, enterally, topically, sublingually, rectally, or in an intramedullary or intracardiac route.
7 . A method for preventing or treating peritoneal fibrosis in a subject in need thereof, comprising administering an effective amount of a composition comprising cyclo(His-Pro) or a pharmaceutically acceptable salt thereof to the subject, wherein the peritoneal fibrosis is epithelial-mesenchymal transition (EMT)-induced peritoneal fibrosis.
8 . The method of claim 7 , wherein the peritoneal fibrosis is caused by dialysis and the composition is administered in a form of peritoneal dialysis solution.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 2, 2021
From: JUNG, HOE YUNE; LEE, DO HYUN; LEE, HEON JONG; KIM, YON SU; YANG, SEUNG HEE
To: NOVMETAPHARMA CO., LTD.; SEOUL NATIONAL UNIVERSITY HOSPITAL; SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Reel/Frame 057998/0774 →
Priority Claims (2)
KR 10-2019-0036269
· Mar 28, 2019
· national
KR 10-2020-0037858
· Mar 27, 2020
· national
Continuity (1)
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