US 20170218042A1
· Tran et al.
· 2017
[cited by applicant]
WO WO2016109559A2
· 2016
[cited by applicant]
WO WO2017070042A1
· 2017
[cited by applicant]
WO WO2018005807A1
· 2018
[cited by applicant]
Xie et al. Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells. Cell Metabolism (2014), 19, 795-809. (Year: 2014).
[cited by examiner]
Granchi et al. Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials. Current Medicinal Chemistry (2010), 17, 672-697. (Year: 2010).
[cited by examiner]
Nagai et al. Cancer prevention from the perspective of global cancer burden patterns. J. Thorac Dis (2017), 9(3), 448-451. (Year: 2017).
[cited by examiner]
Yeung et al. Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma. Cancer Res (epub. Aug. 20, 2019) 79 (19): 5060-5073 plus appended PubMed Abstrac…
[cited by examiner]
Buck et al., “Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming,”
[cited by applicant]
Buck et al., “T cell metabolism drives immunity,”
[cited by applicant]
European Patent Office, International Search Report in International Patent Application No. PCT/US2020/045100, mailed Oct. 23, 2020.
[cited by applicant]
European Patent Office, Written Opinion in International Patent Application No. PCT/US2020/045100, mailed Oct. 23, 2020.
[cited by applicant]
Finlay et al., “PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8
[cited by applicant]
Gattinoni et al., “Wnt signaling arrests effector T cell differentiation and generates CD8
[cited by applicant]
Gattinoni et al., “A human memory T-cell subset with stem cell-like properes,”
[cited by applicant]
Gattinoni et al., “T memory stem cells in health and disease,”
[cited by applicant]
Gautam et al., “The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity,”
[cited by applicant]
Gottfried et al., “Tumor-derived lactic acid modulates dendritic cell activation and antigen expression,”
[cited by applicant]
Hanada et al., “An effective mouse model for adoptive cancer immunotherapy targeting neoantigens,”
[cited by applicant]
Hermans et al., “Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8
[cited by applicant]
Hinrichs et al., “IL-2 and IL-21 confer opposing differentiation programs to CD8
[cited by applicant]
The International Bureau of WIPO, International Preliminary Report on Patentability in International Patent Application No. PCT/US2020/045100, mailed Feb. 17, 2022.
[cited by applicant]
Jang et al., “The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids,”
[cited by applicant]
Kalia et al., “Prolonged Interleukin-2Rα Expression on Virus-Specific CD8
[cited by applicant]
Kim et al., “Regulation of Immune Cell Functions by Metabolic Reprogramming,”
[cited by applicant]
Langmead et al., “Ultrafast and memory-efficient alignment of short DNA sequences to the human genome,”
[cited by applicant]
Lee et al., “An Integrated View of Immunometabolism,”
[cited by applicant]
Liao et al., “Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression,”
[cited by applicant]
Lin et al., “The Common Cytokine Receptor γ Chain Family of Cytokines,”
[cited by applicant]
Lin et al., “Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells,”
[cited by applicant]
Loschinski et al., “IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner,”
[cited by applicant]
Markley et al., “IL-17 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice,”
[cited by applicant]
Mathis et al., “Immunometabolism: an emerging frontier,”
[cited by applicant]
Melamud et al., “Metabolomic Analysis and Visualization Engine for LC-MS Data,”
[cited by applicant]
Metsalu et al., “ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap,”
[cited by applicant]
Noguchi et al., “Interleukin-2 Receptor γ Chain Mutation Results in X-Linked Severe Combined Immunodeficiency in Humans,”
[cited by applicant]
O'Neill et al., “A guide to immunometabolism for immunologists,”
[cited by applicant]
O'Sullivan et al., “Memory CD8
[cited by applicant]
Ozaki et al., “Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain,”
[cited by applicant]
Parrish-Novak et al., “Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function,”
[cited by applicant]
Patten et al., “OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand,”
[cited by applicant]
Peng et al., “Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism,”
[cited by applicant]
Rai et al., “Discovery and Optimization of potent, cell-active pyrazole-based inhibitors of Lactate Dehydrogenase (LDH),”
[cited by applicant]
Robinson et al., “edgeR: a Bioconductor package for differential expression analysis of digital gene expression data,”
[cited by applicant]
Ross et al., “Signaling and Function of Interleukin-2 in T Lymphocytes,”
[cited by applicant]
Sabatino et al., “Generation of clinical-grade CD19-specific CAR-modified CD8
[cited by applicant]
Seo et al., “TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8
[cited by applicant]
Song et al., “IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity,”
[cited by applicant]
Spolski et al., “The γ
[cited by applicant]
Spolski et al., “Interleukin-21: a double-edged sword with therapeutic potential,”
[cited by applicant]
Spolski et al., “Biology and regulation of IL-2: from molecular mechanisms to human therapy,”
[cited by applicant]
Su et al., “Metabolite Spectral Accuracy on Orbitraps,”
[cited by applicant]
Sukumar et al., “Inhibiting glycolytic metabolism enhances CD8
[cited by applicant]
Tran et al., “Cancer Immunotherapy Based on Mutation-Specific CD4
[cited by applicant]
Tyrakis et al., “The immunometabolite S-2-hydroxyglutarate regulates CD8
[cited by applicant]
Van Der Windt et al., “Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8
[cited by applicant]
Verdeil, “MAF drives CD8
[cited by applicant]
Wang et al., “Metabolic reprogramming and metabolic dependency in T cells,”
[cited by applicant]
Warburg, “On the Origin of Cancer Cells,” Science, 123(3191): 309-314 (1956).
[cited by applicant]
Wherry et al., “Molecular and cellular insights into T cell exhaustion,”
[cited by applicant]
Xie et al., “Targeting lactate dehydrogenase-A inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells,”
[cited by applicant]
Zeng et al., “The molecular basis of IL-21-mediated proliferation,”
[cited by applicant]
Zeng et al., “mTORC1 couples immune signals and metabolic programming to establish T
[cited by applicant]
Zhang et al., “Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner,”
[cited by applicant]