IP Library › Granted Patent US 12,559,867
Granted Patent B2
US 12,559,867 · App. 17/607,896 · Granted Feb 24, 2026

Fibers of polymers that have a backbone including a positively charged component of a zwitterionic moiety, and their use in implantable therapeutic delivery systems

Inventors: Minglin Ma (Ithaca, NY); Qingsheng Liu (Ithaca, NY); Xi Wang (Ithaca, NY); James A. Flanders (Ithaca, NY)
Assignee: CORNELL UNIVERSITY
D01F6/70A61L17/005A61L17/10A61L17/145A61L27/18A61L27/52A61L27/54A61L27/56D01F6/80
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Quick Facts
Patent No.
US 12,559,867
App. No.
17/607,896
Granted
Feb 24, 2026
Kind
B2
Abstract

The present application relates to fibers having a diameter of 1 nm to 10,000 nm, of one or more biocompatible polymers, wherein the polymers have a backbone which includes a positively charged component from a zwitterionic moiety. Additionally, this application discloses an implantable therapeutic delivery system and its method of formation, comprising a housing defining a chamber, wherein said housing is porous and formed from the fibers. Inside of the housing includes a preparation of cells which release a therapeutic agent from the chamber. The implantable therapeutic delivery system can be used in the treatment of diabetes.

Claims (19)

1 . A fiber having a diameter of 1 nm to 10,000 nm, of one or more biocompatible polymers, wherein the one or more biocompatible polymers comprise a polymer of the formula

wherein n is an independently selected integer from 1 to 20.

2 . An implantable therapeutic delivery system comprising:

a housing defining a chamber, wherein said housing is porous and formed from fibers of one or more biocompatible polymers, said fibers having a diameter of 1 nm to 10,000 nm, and the one or more biocompatible polymers comprising a polymer of the formula

wherein n is an independently selected integer from 1 to 20.

3 . The implantable therapeutic delivery system of claim 2 , wherein the housing is an elongate hollow porous tube extending between first and second ends with the fibers being wound around the chamber.

4 . The implantable therapeutic delivery system of claim 3 , wherein the elongate hollow porous tube has a sealed first end.

5 . The implantable therapeutic delivery system of claim 3 , wherein the chamber of elongate hollow porous tube contains a hydrogel.

6 . The implantable therapeutic delivery system of claim 5 , wherein the hydrogel comprises alginate.

7 . The implantable therapeutic delivery system of claim 5 , wherein the hydrogel and elongate hollow porous tube are crosslinked.

8 . The implantable therapeutic delivery system of claim 5 , wherein the elongate hollow porous tube is sealed at the first and second ends so that the chamber is closed.

9 . The implantable therapeutic delivery system of claim 8 further comprising:

a preparation of cells within the closed chamber which release a therapeutic agent from the chamber through the elongate hollow porous tube.

10 . The implantable therapeutic delivery system of claim 9 , wherein the cells are islet cells.

11 . The implantable therapeutic delivery system of claim 9 , wherein the cells are stem cells.

12 . The implantable therapeutic delivery system of claim 3 , wherein the elongate hollow porous tube has pores of a diameter of 10 nm to 1 mm.

13 . The implantable therapeutic delivery system of claim 3 , wherein the chamber of the elongate hollow porous tube has a diameter of 0.1 mm to 10 cm.

14 . The implantable therapeutic delivery system of claim 3 , wherein the elongate hollow porous tube has a wall thickness of 10 μm to 1 cm.

15 . The implantable therapeutic delivery system of claim 3 , wherein the elongate hollow porous tube has a length of 1 cm to 10 m.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 2, 2022
From: WANG, XI; FLANDERS, JAMES A.; MA, MINGLIN; LIU, QINGSHENG
To: CORNELL UNIVERSITY
Reel/Frame 058521/0870 →
Continuity (2)
Provisional Application 62840827 · Apr 30, 2019
Related Publication 20220380944A1 · Dec 1, 2022
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