Granted Patent
B2
US 12,569,422 · App. 17/284,643 · Granted Mar 10, 2026
Composition and method of inhibiting cortisone reductase by applying it to the skin
Inventors:
Eun Jeong Choi (Yongin-si, KR); Young Gyu Kang (Yongin-si, KR); Jihyun Kim (Yongin-si, KR); Euidong Son (Yongin-si, KR); Gayoung Cho (Yongin-si, KR); Sowoong Choi (Yongin-si, KR); Hyoung June Kim (Yongin-si, KR); Tae Ryong Lee (Yongin-si, KR)
Assignee:
AMOREPACIFIC CORPORATION
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Abstract
Provided are a composition including coumestrol extracted from soybeans as an active ingredient, and a method of inhibiting cortisone reductase by applying it to skin of a subject.
Claims (6)
1 . A method of improving skin barrier function that has been compromised by an increase in the cortisol level within the epidermis in a subject, comprising applying an effective amount of a composition to skin of the subject,
wherein the composition comprises coumestrol extracted from soybeans as an active ingredient in a concentration range of 0.001 μM to 10 μM,
wherein the increase in cortisol level within the epidermis is caused by mental stress,
wherein the increase in cortisol level within the epidermis caused by mental stress is simulated by UV irradiation and the addition of cortisone to human keratinocytes, and
wherein the composition is a cosmetic composition.
2 . The method of claim 1 , wherein the soybeans comprise beans selected from soybean peas and mung beans, germinated beans germinated from the beans, or a combination thereof.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 12, 2021
From: CHOI, EUN JEONG; KANG, YOUNG GYU; KIM, JIHYUN; SON, EUIDONG; CHO, GAYOUNG; CHOI, SOWOONG; KIM, HYOUNG JUNE; LEE, TAE RYONG
To: AMOREPACIFIC CORPORATION
Reel/Frame 055893/0231 →
Priority Claims (1)
KR 10-2018-0120692
· Oct 10, 2018
· national
Continuity (1)
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