Sunscreen composition and methods of protection from ultraviolet and visible light
Provided herein is a method of reducing or preventing sunburn caused from visible and ultraviolet radiation in a subject, the method comprising topically applying to the subject a sunscreen composition comprising inorganic UV filtering agents, antioxidants, and at least one inorganic pigment, wherein the at least one inorganic pigments and antioxidants are present in an amount effective to reduce or prevent sunburn caused from visible light. Also provided herein are sunscreen compositions and methods of increasing the SPF of a sunscreen composition that comprises at least one inorganic UV filtering agent.
1 . A method of reducing or preventing sunburn caused from visible light and ultraviolet (UV) radiation in a subject, comprising topically applying to the subject a sunscreen composition comprising:
(a) inorganic UV filtering agents comprising nanosized zinc oxide and nanosized titanium dioxide, present in the sunscreen composition in a total amount ranging from about 10% to about 50% by weight based on a total weight of the sunscreen composition, wherein the nanosized zinc oxide has a mean particle size ranging from about 10 nm to about 100 nm and the nanosized titanium oxide has a mean particle size ranging from about 5 nm to about 500 nm;
(b) at least one antioxidant present in the sunscreen composition in a total amount ranging from about 0.1% to about 5% by weight relative to the total weight of the sunscreen composition; and
(c) at least one inorganic pigment comprising iron oxide, present in the sunscreen composition in a total amount ranging from about 0.01% to about 5% by weight relative to the total weight of the sunscreen composition,
wherein the at least one inorganic pigment and the at least one antioxidant are present in an amount effective to reduce or prevent sunburn caused from visible light.
2 . The method according to claim 1 , wherein the iron oxide is chosen from the group consisting of black iron oxide, brown iron oxide, red iron oxide, yellow iron oxide, and mixtures thereof.
3 . The method according to claim 1 , wherein the nanosized zinc oxide has a mean particle size ranging from about 60 nm to about 80 nm.
4 . The method according to claim 1 , wherein the nanosized titanium dioxide has a mean particle size ranging from about 5 nm to about 20 nm.
5 . The method according to claim 1 , wherein at least one of the nanosized zinc oxide, the nanosized titanium dioxide, and the iron oxide further comprises a coating.
6 . The method according to claim 5 , wherein the coating is triethoxycaprylylsilane.
7 . The method according to claim 1 , wherein at least one antioxidant is selected from vitamin A, vitamin C, vitamin E, selenium, carotenoids, thiols, and derivatives and mixtures thereof.
8 . The method according to claim 7 , wherein the vitamin E or derivatives thereof is chosen from the group consisting of tocopherol and tocopherol acetate or wherein the vitamin C or derivatives thereof is chosen from the group consisting of ascorbic acid and tetrahexyldecyl ascorbate.
9 . The method according to claim 1 , wherein the at least one inorganic pigment further comprises at least one inorganic pigment selected from the group consisting of a pigmentary zinc oxides and a pigmentary titanium dioxide.
10 . The method according to claim 9 , wherein the pigmentary titanium dioxide has a mean particle size ranging from about 1 μm to about 20 μm.
11 . A method of increasing a sunscreen protection factor (SPF) of a sunscreen composition that comprises inorganic UV filtering agents comprising nanosized zinc oxide and nanosized titanium dioxide, wherein the nanosized zinc oxide has a mean particle size ranging from about 10 nm to about 100 nm and the nanosized titanium oxide has a mean particle size ranging from about 5 nm to about 500 nm, the method comprising adding to the sunscreen composition (a) at least one antioxidant present in the sunscreen composition in a total amount ranging from about 0.1% to about 5% by weight relative to the total weight of the sunscreen composition; and (b) at least one inorganic pigment comprising iron oxide present in the sunscreen composition in a total amount ranging from about 0.01% to about 5% by weight relative to the total weight of the sunscreen composition,
wherein the inorganic pigments and at least one antioxidant are present in an amount effective to increase the SPF of the sunscreen composition when tested under outdoor solar exposure.
12 . The method according to claim 11 , wherein the SPF is increased by an SPF of at least about 3.
13 . The method according to claim 11 , wherein the sunscreen composition does not comprise an organic UV filtering agent.
14 . The method according to claim 11 , wherein the at least one inorganic pigment further comprises at least one inorganic pigment selected from the group consisting of pigmentary titanium dioxides and pigmentary zinc oxides.
15 . The method according to claim 11 , wherein the nanosized zinc oxide has a mean particle size ranging from about 60 nm to about 80 nm.
16 . The method according to claim 11 , wherein the nanosized titanium dioxide has a mean particle size ranging from about 5 nm to about 20 nm.
17 . The method according to claim 11 , wherein the at least one antioxidant is selected from vitamin A, vitamin C, vitamin E, selenium, carotenoids, thiols, and derivatives and mixtures thereof.
18 . The method according to claim 17 , wherein the vitamin E or derivatives thereof is chosen from the group consisting of tocopherol and tocopherol acetate or wherein the vitamin C or derivatives thereof is chosen from the group consisting of ascorbic acid and tetrahexyldecyl ascorbate.
19 . The method according to claim 14 , wherein the pigmentary titanium dioxide has a mean particle size ranging from about 1 μm to about 20 μm.
20 . A sunscreen composition comprising:
(a) inorganic UV filtering agent comprising nanosized zinc oxide and nanosized titanium dioxide, present in the sunscreen composition in a total amount ranging from about 10% to about 50% by weight based on a total weight of the sunscreen composition, wherein the nanosized zinc oxide has a mean particle size ranging from about 10 nm to about 100 nm and the nanosized titanium oxide has a mean particle size ranging from about 5 nm to about 500 nm;
(b) at least one antioxidant present in the sunscreen composition in a total amount ranging from about 0.1% to about 5% by weight relative to the total weight of the sunscreen composition; and
(c) inorganic pigments comprising iron oxide present in the sunscreen composition in a total amount ranging from about 0.01% to about 5% by weight relative to the total weight of the sunscreen composition,
wherein the inorganic pigments and antioxidants are present in an amount effective to reduce or prevent sunburn caused from visible light.