IP Library › Granted Patent US 12,582,683
Granted Patent B2
US 12,582,683 · App. 18/342,322 · Granted Mar 24, 2026

Prostate neoantigens and their uses

Inventors: Kurtis E. Bachman (Chester Springs, PA); Vipul Bhargava (Springfield, PA); Darryl L. Davis (Collegeville, PA); Vinod Krishna (Philadelphia, PA); Guido Leoni (Rome, IT); David Pocalyko (Doylestown, PA); Pegah Safabakhsh (Philadelphia, PA); Manuel Sepulveda (West Windsor, NJ); Derick Siegel (Radnor, PA); Marco Gottardis (Princeton, NJ)
Assignee: Janssen Biotech, Inc.
A61K35/761A61K39/0011A61K39/001193A61K39/001194A61K39/001195C07K16/3069A61K2039/51A61K2039/545A61K2039/572A61K45/06
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Quick Facts
Patent No.
US 12,582,683
App. No.
18/342,322
Granted
Mar 24, 2026
Kind
B2
Abstract

The disclosure relates to prostate neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the prostate neoantigens, and methods of making and using them.

Claims (25)

1 . A method of treating prostate cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a vaccine comprising:

a) a heterologous polynucleotide encoding a heterologous polypeptide comprising SEQ ID NOs: 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177; or

b) a heterologous polynucleotide comprising SEQ ID NOs: 276, 382, 334, 338, 270, 254, 310, 326, 272, 306, 252, 246, 262, 266, 318, 256, 298, 286, 448, 450, 453, 455, 380, 344, 212, 350, 214, 216, 222, 220, 226, 346, 354, 236, 224, 168, 172, 20, 24, and 178.

2 . The method of claim 1 , wherein the subject is treatment naïve.

3 . The method of claim 1 , wherein the prostate cancer is a relapsed prostate cancer, a refractory prostate cancer, a metastatic prostate cancer, a castration resistant prostate cancer, or any combination thereof.

4 . The method of claim 3 , wherein the subject has received androgen deprivation therapy.

5 . The method of claim 1 , wherein the subject has an elevated level of prostate specific antigen (PSA).

6 . The method of claim 1 , further comprising administering an additional cancer therapeutic agent to the subject.

7 . The method of claim 6 , wherein the additional cancer therapeutic agent is a surgery, a chemotherapy, an androgen deprivation therapy, radiation, a checkpoint inhibitor, a targeted therapy, or any combination thereof.

8 . The method of claim 7 , wherein the additional cancer therapeutic agent is a CTLA-4 antibody, a CTLA-4 ligand, a PD-1 axis inhibitor, a PD-L1 axis inhibitor, a TLR agonist, a CD40 agonist, an OX40 agonist, hydroxyurea, ruxolitinib, fedratinib, a 4-1BB agonist, a CD28 agonist, a STING antagonist, a RIG-1 antagonist, a TCR-T therapy, a CAR-T therapy, a FLT3 ligand, aluminum sulfate, a BTK inhibitor, a CD38 antibody, a CDK inhibitor, a CD33 antibody, a CD37 antibody, a CD25 antibody, a GM-CSF inhibitor, IL-2, IL-15, IL-7, CD3 redirection molecules, pomalimib, IFNy, IFNa, TNFa, a VEGF antibody, a CD70 antibody, a CD27 antibody, a BCMA antibody, a GPRC5D antibody, or any combination thereof.

9 . The method of claim 7 , wherein the checkpoint inhibitor is ipilimumab, cetrelimab, pembrolizumab, nivolumab, sintilimab, cemiplimab, toripalimab, camrelizumab, tislelizumab, dostralimab, spartalizumab, prolgolimab, balstilimab, budigalimab, sasanlimab, avelumab, atezolizumab, durvalumab, envafolimab, iodapolimab, or any combination thereof.

10 . The method of claim 1 , wherein the vaccine comprises a heterologous polynucleotide encoding a heterologous polypeptide comprising SEQ ID NOs: 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177.

11 . The method of claim 1 , wherein the vaccine comprises a heterologous polynucleotide comprising SEQ ID NOs: 276, 382, 334, 338, 270, 254, 310, 326, 272, 306, 252, 246, 262, 266, 318, 256, 298, 286, 448, 450, 453, 455, 380, 344, 212, 350, 214, 216, 222, 220, 226, 346, 354, 236, 224, 168, 172, 20, 24, and 178.

12 . The method of claim 1 , wherein the vaccine is a DNA vaccine.

13 . The method of claim 1 , wherein the vaccine is an RNA vaccine.

14 . The method of claim 1 , wherein the vaccine is a recombinant virus.

15 . The method of claim 14 , wherein the recombinant virus is derived from adenovirus, poxvirus, AAV, or retrovirus.

16 . The method of claim 15 , wherein the recombinant virus is derived from hAd5, hAd7, hAd11, hAd26, hAd34, hAd35, hAd48, hAd49, hAd50, GAd20, GAd19, GAd21, GAd25, GAd26, GAd27, GAd28, GAd29, GAd30, GAd31, ChAd3, ChAd4, ChAd5, ChAd6, ChAd7, ChAd8, ChAd9, ChAd10, ChAd11, ChAd16, ChAd17, ChAd19, ChAd20, ChAd22, ChAd24, ChAd26, ChAd30, ChAd31, ChAd37, ChAd38, ChAd44, ChAd55, ChAd63, ChAd73, ChAd82, ChAd83, ChAd146, ChAd147, PanAd1, PanAd2, PanAd3, Copenhagen vaccinia virus (W), New York Attenuated Vaccinia Virus (NYVAC), ALVAC, TROVAC, or MVA.

17 . The method of claim 16 , wherein the recombinant virus is derived from GAd20.

18 . The method of claim 16 , wherein the recombinant virus is derived from MVA.

19 . The method of claim 1 , wherein the vaccine is administered one or more times to the subject.

20 . The method of claim 10 , wherein the vaccine is a recombinant virus derived from MVA.

21 . The method of claim 10 , wherein the vaccine is a recombinant virus derived from GAd20.

22 . The method of claim 11 , wherein the vaccine is a recombinant virus derived from MVA.

23 . The method of claim 11 , wherein the vaccine is a recombinant virus derived from GAd20.

Continuity (6)
Division 16737950 · Jan 9, 2020
Provisional Application 62913969 · Oct 11, 2019
Provisional Application 62883786 · Aug 7, 2019
Provisional Application 62851273 · May 22, 2019
Provisional Application 62790673 · Jan 10, 2019
Related Publication 20240139265A1 · May 2, 2024
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