Salt form and crystal form of A2A receptor antagonist and preparation method therefor
Provided are a salt form and a crystal form of adenosine A 2A receptor antagonist, and preparation method therefor. Also provided is an application of the salt form or crystal form in the preparation of a medicine for A 2A receptor-related diseases, the maleate salt in the salt form has a structure of formula (I).
1 . A crystal form of the compound of formula (I),
wherein an X-ray powder diffraction pattern thereof has characteristic diffraction peaks at the following 2θ angles: 7.16±0.2°, 9.66±0.2°, and 19.66±0.2°.
2 . The crystal form of the compound of formula (I) according to claim 1 , wherein the X-ray powder diffraction pattern thereof has additional characteristic diffraction peaks at the following 2θ angles: 13.59±0.2°, 14.30±0.2°, 15.87±0.2°, 17.73±0.2°, and 20.88±0.2°;
or, wherein a differential scanning calorimetry curve thereof has an onset of an endothermic peak at 205.67±3° C.;
or, wherein a thermogravimetric analysis curve thereof has a weight loss of 0.1846% at 120.00° C.±3° C.
3 . The crystal form of the compound of formula (I) according to claim 2 , wherein the X-ray powder diffraction pattern thereof has additional characteristic diffraction peaks at the following 2θ angles: 26.01±0.2°, 26.76±0.2°, and 27.21±0.2°.
4 . The crystal form of the compound of formula (I) according to claim 3 , wherein the XRPD pattern thereof is shown in FIG. 1 ;
or, a DSC pattern thereof is shown in FIG. 2 ;
or, a TGA pattern thereof is shown in FIG. 3 .