3-((1H-pyrazol-4-yl)methyl)-6′-(phenyl)-2H-(1,2′-bipyridin)-2-one derivatives and related compounds as GPR139 antagonists for use in a method of treatment of e.g. depression
The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer's disease, schizophrenia, drug addiction, sleep disorders, pain, and attention deficit hyperactivity disorder. Exemplary compounds are e.g. 3-((1H-pyrazol-4-yl)methyl)-6′-(phenyl)-2H-(1,2′-bipyridin)-2-one derivatives and related compounds. The present description discloses the synthesis and characterisation of exemplary compounds, pharmacological data thereof, as well as exemplary tablet formulations comprising the compounds of the invention (e.g. page 83 to page 110; examples 1 to 33; reference example 1; test examples 1 and 2; tables 1 to 4).
1 . A compound of Formula (I)
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is
ring A 1 is chosen from 6-membered aromatic rings optionally further substituted with 1 to 3 substituents chosen from:
(a) halogen atoms;
(b) cyano groups;
(c) optionally halogenated C 1-6 alkyl groups;
(d) optionally halogenated C 1-6 alkoxy groups; and
(e) C 3-10 cycloalkyl groups optionally substituted with 1 to 3 halogen atoms;
ring A 2 is chosen from 5-membered monocyclic aromatic heterocyclic rings optionally further substituted with 1 to 3 substituents chosen from:
(a) halogen atoms;
(b) cyano groups;
(c) optionally halogenated C 1-6 alkyl groups;
(d) optionally halogenated C 1-6 alkoxy groups; and
(e) C 3-10 cycloalkyl groups;
ring B is chosen from pyridone rings optionally further substituted with 1 to 3 substituents chosen from halogen atoms and C 1-6 alkyl groups;
R 2 and R 3 are each independently chosen from a hydrogen atom and C 1-6 alkyl groups;
R 4a and R 4b are each independently chosen from substituents:
(1) C 6-14 aryl groups optionally substituted with 1 to 3 halogen atoms;
(2) 3- to 14-membered non-aromatic heterocyclic groups optionally substituted with 1 to 3 substituents chosen from:
(a) halogen atoms; and
(b) optionally halogenated C 1-6 alkyl groups;
(3) mono- or di-C 1-6 alkylamino groups optionally substituted with 1 to 3 C 3-10 cycloalkyl groups optionally substituted with 1 to 3 halogen atoms; and
(4) 3- to 14-membered non-aromatic heterocyclic oxy groups; and
ring C is chosen from 5-membered monocyclic aromatic heterocyclic rings optionally further substituted with 1 to 3 substituents independently chosen from C 1-6 alkyl groups.
2 . The compound or pharmaceutically acceptable salt according to claim 1 , wherein the compound is chosen from compounds of Formula (I′)
and pharmaceutically acceptable salts thereof, wherein:
X is CH or N;
Y is CH or N;
Z is chosen from a bond, —O—, —OR 9a —*, —NH—, and —N(R 9b )R 9a —*, wherein * denotes the connection point to ring D;
ring C is chosen from 5-membered monocyclic aromatic heterocyclic rings;
ring D is chosen from 6- to 8-membered aromatic rings, 5- to 8-membered monocyclic aromatic heterocyclic rings, C 3-8 cycloalkyl groups, and 5- to 8-membered heterocyclic groups;
R 2 and R 3 are each independently chosen from a hydrogen atom and C 1-6 alkyl groups;
each R 7a is independently chosen from cyano, halogen, C 3-6 cycloalkyl, C 1-6 alkyl, and C 1-6 alkoxy groups, wherein the C 3-6 cycloalkyl, C 1-6 alkyl, and C 1-6 alkoxy groups are optionally substituted with 1 to 4 halogen atoms;
each R 8a is independently chosen from halogen, C 1-6 alkyl, and C 1-6 alkoxy groups, wherein the C 1-6 alkyl and C 1-6 alkoxy groups are optionally substituted with 1 to 4 halogen atoms;
R 9a is chosen from C 1-3 alkyl groups;
R 9b is chosen from hydrogen atom and C 1-3 alkyl groups;
each R 10a is independently chosen from halogen atoms and C 1-3 alkyl groups;
each R 11a is independently chosen from C 1-3 alkyl groups;
m is 0, 1, 2, or 3;
n is 0, 1, 2, or 3;
is 0, 1, or 2; and
p is 0, 1, or 2.
3 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein:
wherein Z, R 7a , R 8a , m, and n are as defined in claim 2 .
4 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein Z is a bond.
5 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein Z is —O—.
6 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein Z is —NHCH 2 —*.
7 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein Z is —N(CH 3 )CH 2 —*.
8 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein ring D is chosen from benzene, morpholine, oxane, piperidine, and cyclobutane.
9 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein
and wherein X, Y, R 7a , R 8a , m, and n are as defined in claim 2 .
10 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein X is CH.
11 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein X is N.
12 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein Y is CH.
13 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein Y is N.
14 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein
and wherein X, R 7a , R 8a , m, and n are as defined in claim 2 .
15 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein
and wherein X, R 7a , R 8a , m, and n are as defined in claim 2 .
16 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein R 2 and R 3 are both hydrogen atoms.
17 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein ring C is
18 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein o is 1 and R 10a is methyl or a fluorine atom.
19 . The compound or pharmaceutically acceptable salt according to claim 2 , wherein o is 0.
20 . A compound chosen from:
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6′-(4-fluorophenyl)-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6′-(4-fluorophenyl)-2-oxo-4′-(trifluoromethyl)-2H-[1,2′-bipyridine]-3′-carbonitrile;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6′-(4-fluorophenyl)-2-oxo-4′-(2,2,2-trifluoroethoxy)-2H-[1,2′-bipyridine]-3′-carbonitrile;
4′-(2,2-difluoroethoxy)-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6′-(4-fluorophenyl)-2-oxo-2H-[1,2′-bipyridine]-3′-carbonitrile;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6′-(4-fluorophenyl)-6-methyl-2-oxo-4′-(trifluoromethyl)-2H-[1,2′-bipyridine]-3′-carbonitrile;
4′-(difluoromethyl)-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6′-(4-fluorophenyl)-2-oxo-2H-[1,2′-bipyridine]-3′-carbonitrile;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-3′-fluoro-6′-[(2R)-2-methylmorpholin-4-yl]-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-5′-methyl-6′-[(2R)-2-methylmorpholin-4-yl]-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-1-{2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]-3-(trifluoromethyl)phenyl}pyridin-2 (1H)-one;
6′-[2-(difluoromethyl) morpholin-4-yl]-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-3′-fluoro-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-3′-fluoro-4-methyl-6′-[(2R)-2-methylmorpholin-4-yl]-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-3′-fluoro-5-methyl-6′-[(2R)-2-methylmorpholin-4-yl]-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-3′-fluoro-6′-[(oxan-4-yl)oxy]-4′-(trifluoromethyl)-2H-[1,2′-bipyridin]-2-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-1-[4-{[(1-fluorocyclobutyl)methyl]amino}-6-(trifluoromethyl)pyrimidin-2-yl]pyridin-2 (1H)-one;
1-[4-{[(3,3-difluorocyclobutyl)methyl]amino}-6-(trifluoromethyl)pyrimidin-2-yl]-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
1-[4-{[(3,3-difluorocyclobutyl)methyl](methyl)amino}-6-(trifluoromethyl)pyrimidin-2-yl]-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-1-[4 {[(1-fluorocyclobutyl)methyl](methyl)amino}-6-(trifluoromethyl)pyrimidin-2-yl]pyridin-2 (1H)-one;
1-{3-cyclopropyl-2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
1-[3-cyclopropyl-5-(2,2-dimethylmorpholin-4-yl)-2-fluorophenyl]-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
1-{3-cyclopropyl-2-fluoro-5-[(oxan-4-yl)oxy]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
1-{3-bromo-2-fluoro-5-[(oxan-4-yl)oxy]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-1-{2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]-3-(trifluoromethoxy)phenyl}pyridin-2 (1H)-one;
1-{3-cyclopropyl-2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-{[1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}pyridin-2 (1H)-one;
1-{3-cyclopropyl-2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-4-fluoropyridin-2 (1H)-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-1-{2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]-3-(propan-2-yl)phenyl}pyridin-2 (1H)-one;
3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-1-{2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]-3-(2,2,2-trifluoroethyl)phenyl}pyridin-2 (1H)-one;
1-{3-cyclopropyl-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6-methylpyridin-2 (1H)-one;
1-[3-(2,2-difluorocyclopropyl)-5-(4,4-difluoropiperidin-1-yl)-2-fluorophenyl]-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]pyridin-2 (1H)-one;
1-{3-cyclopropyl-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-6-fluoropyridin-2 (1H)-one;
1-{3-cyclopropyl-2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-5-methylpyridin-2 (1H)-one; and
1-{3-cyclopropyl-2-fluoro-5-[(2R)-2-methylmorpholin-4-yl]phenyl}-3-[(1-ethyl-1H-pyrazol-4-yl)methyl]-4-methylpyridin-2 (1H)-one, or
a pharmaceutically acceptable salt of any of the foregoing.
21 . A pharmaceutical composition comprising:
at least one compound or pharmaceutically acceptable salt according to claim 1 ; and
at least one pharmaceutically acceptable carrier.
22 . A method of treating or preventing a disease in a mammal in need thereof, the method comprising administering to the mammal at least one compound or pharmaceutically acceptable salt according to claim 1 .
23 . The method according to claim 22 , wherein the disease is chosen from depression, Alzheimer's disease, schizophrenia, drug addiction, sleep disorders, pain, and attention deficit hyperactivity disorder.
24 . The method according to claim 22 , wherein the mammal is a human.
25 . The method according to claim 22 , further comprising administering to the mammal at least one combination drug.
26 . A pharmaceutical composition comprising:
at least one compound or pharmaceutically acceptable salt according to claim 2 ; and at least one pharmaceutically acceptable carrier.
27 . A method of treating or preventing a disease in a mammal in need thereof, the method comprising administering to the mammal at least one compound or pharmaceutically acceptable salt according to claim 2 .