IP Library › Granted Patent US 12,596,067
Granted Patent B2
US 12,596,067 · App. 18/198,523 · Granted Apr 7, 2026

Compact high resolution monochromatic light source for fluid sample concentration measurement

Inventors: Matthew Muller (Cranford, NJ); Richard Hall, III (Bernardsville, NJ); Yusheng Zhang (Stewartsville, NJ); Peter Halatin (Howell, NJ)
Assignee: Repligen Corporation
G01N21/255G01J3/10G01J3/42G01N21/3103
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Quick Facts
Patent No.
US 12,596,067
App. No.
18/198,523
Granted
Apr 7, 2026
Kind
B2
Abstract

A compact light source for coupling to a movable optic probe may include a light emitting diode (LED), to generate a probe signal at a first bandwidth, an optic coupler, disposed adjacent to the LED, and arranged to couple the probe signal into the movable probe, and a narrow bandpass filter disposed to receive the probe signal at the first bandwidth, and to output the probe signal into the movable probe at a second bandwidth, less than the first bandwidth.

Claims (36)

1 . A compact light source for coupling to a movable probe, comprising:

a light emitting diode (LED), to generate a probe signal at a first bandwidth;

an optic coupler, disposed adjacent to the LED, and arranged to couple the probe signal into the movable probe; and

a narrow bandpass filter disposed to receive the probe signal at the first bandwidth, and to output the probe signal into the movable probe at a second bandwidth, less than the first bandwidth,

wherein the LED, the optic coupler, and the narrow bandpass filter form a monochromatic light source.

2 . The compact light source of claim 1 , wherein the first bandwidth is at least 10 nm, and wherein the second bandwidth is less than 1 nm.

3 . The compact light source of claim 1 , further comprising a housing, to contain the LED, the optic coupler, and the narrow bandpass filter.

4 . The compact light source of claim 3 , further comprising a connector to reversibly couple to the movable optic probe.

5 . The compact light source of claim 1 , the probe signal comprising a monochromatic signal characterized by a wavelength in a range of ultraviolet (UV) to infrared (IR) wavelengths, and having a bandwidth of less than 1 nm after exiting the compact light source.

6 . A measurement apparatus, comprising:

a compact light source, comprising a light emitting diode (LED) to generate a probe signal; the compact light source further comprising an optic coupler disposed adjacent to the LED, and a narrow bandpass filter disposed to receive the probe signal at a first bandwidth, and to output the probe signal at a second bandwidth, less than the first bandwidth; and

a measurement instrument, to receive the probe signal, the measurement instrument comprising:

a sample vessel to contain a fluid sample, the sample vessel comprising a vessel wall;

a probe, arranged to direct the probe signal through the sample vessel, wherein the probe is movable along a probe direction with respect to the vessel wall, so as to reduce a path length of the probe signal through the fluid sample; and

a detector, disposed to receive the probe signal after passing through the vessel wall,

wherein the LED, the optic coupler, and the narrow bandpass filter form a monochromatic light source.

7 . The measurement apparatus of claim 6 , wherein the second bandwidth is less than 1 nm.

8 . The measurement apparatus of claim 6 , wherein the LED, the optic coupler, and the narrow bandpass filter are disposed within a common housing.

9 . The measurement apparatus of claim 8 , wherein the compact light source is reversibly attachable and detachable with respect to the measurement instrument.

10 . The measurement apparatus of claim 6 , wherein the measurement instrument is arranged to conduct the fluid sample through the sample vessel.

11 . The measurement apparatus of claim 6 , the probe signal comprising a monochromatic signal characterized by a wavelength in a range of ultraviolet (UV) to infrared (IR) wavelengths, and having a bandwidth of less than 1 nm after exiting the compact light source.

12 . A system to measure a concentration of a material in a fluid sample, comprising:

a compact light source, comprising a light emitting diode (LED), to generate a probe signal, an optic coupler, disposed adjacent to the LED; and a narrow bandpass filter disposed to receive the probe signal at a first bandwidth, and to output the probe signal at a second bandwidth, less than the first bandwidth;

a measurement instrument, to receive the probe signal, the measurement instrument comprising:

a sample vessel to contain a fluid sample, the sample vessel comprising a vessel wall;

a probe, having a probe tip, arranged to direct the probe signal through the sample vessel, wherein the probe is movable along a probe direction with respect to the vessel wall, so as to reduce a path length of the probe signal through the fluid sample; and

a detector, disposed to receive the probe signal after passing through the vessel wall,

wherein the LED, the optic coupler, and the narrow bandpass filter form a monochromatic light source.

13 . The system of claim 12 , the probe signal comprising a monochromatic signal characterized by a wavelength in a range of ultraviolet (UV) to infrared (IR) wavelengths, and having a bandwidth of less than 1 nm after exiting the compact light source.

14 . The system of claim 12 , wherein the LED, the optic coupler, and the narrow bandpass filter are disposed within a common housing.

15 . The system of claim 12 , wherein the compact light source is reversibly attachable and detachable with respect to the measurement instrument.

16 . The system of claim 12 , wherein the measurement instrument is arranged to conduct the fluid sample through the sample vessel.

17 . The system of claim 12 , the sample vessel further comprising:

an inlet port to admit the fluid sample;

an outlet port to conduct the fluid sample out of the sample chamber vessel; and

a transparent window disposed between the probe tip and the detector.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 8, 2024
From: MULLER, MATTHEW; HALL, RICHARD, III; ZHANG, YUSHENG; HALATIN, PETER
To: REPLIGEN CORPORATION
Reel/Frame 066703/0592 →
Continuity (2)
Provisional Application 63343361 · May 18, 2022
Related Publication 20230400405A1 · Dec 14, 2023
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