IP Library › Granted Patent US 12,599,658
Granted Patent B2
US 12,599,658 · App. 17/616,939 · Granted Apr 14, 2026

Hepatitis B virus-specific T cell responses

Inventors: Klaus J. Früh (Portland, OR); Louis J. Picker (Portland, OR); Benjamin J. Burwitz (Portland, OR); Scott G. Hansen (Portland, OR); Jonah B. Sacha (Beaverton, OR)
Assignee: Oregon Health & Science University
A61K39/12A61K39/001129A61K40/11A61K40/46A61K47/30A61P31/12A61K2039/5256A61K2039/572
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Quick Facts
Patent No.
US 12,599,658
App. No.
17/616,939
Granted
Apr 14, 2026
Kind
B2
Abstract

The present disclosure relates to methods to generate an immune response for the treatment or prevention of hepatitis B virus infection. This disclosure also relates to methods to generate MHC-E and/or MHC-II restricted CD8+ T cells for the treatment or prevention of hepatitis B virus infection.

Claims (6)

1 . A method of generating an immune response to a hepatitis B virus (HBV) in a subject, the method comprising administering to the subject a cytomegalovirus (CMV) vector expressing a HBV antigen in an amount effective to elicit a CD8+ T cell response to the HBV antigen, wherein the CMV vector does not express UL128, UL130, UL146, and UL147 proteins or orthologs thereof, wherein the hepatitis B antigen is PSVRDLLDTASALYR (SEQ ID NO: 17) or TALRQAILCWGELMT (SEQ ID NO: 18).

2 . The method of claim 1 , wherein the hepatitis B antigen is PSVRDLLDTASALYR (SEQ ID NO: 17).

3 . The method of claim 1 , wherein the hepatitis B antigen is TALRQAILCWGELMT (SEQ ID NO: 18).

4 . The method of claim 1 , wherein at least 10% of the CD8+ T cells elicited by the CMV vector are restricted by MHC-E or an ortholog thereof, or MHC-II or an ortholog thereof.

5 . The method of claim 1 , wherein fewer than 10% of the CD8+ T cells elicited by the CMV vector are restricted by MHC-class 1 a or an ortholog thereof.

6 . The method of claim 4 , wherein some of the CD8+ T cells restricted by MHC-E recognize epitopes shared by at least 90% of other subjects immunized with the vector.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 5, 2025
From: FRUEH, KLAUS J.; PICKER, LOUIS J.; BURWITZ, BENJAMIN J.; HANSEN, SCOTT G.; SACHA, JONAH B.
To: OREGON HEALTH & SCIENCE UNIVERSITY
Reel/Frame 070126/0416 →
Continuity (2)
Provisional Application 62858764 · Jun 7, 2019
Related Publication 20220257748A1 · Aug 18, 2022
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