IP Library Granted Patent US 12,601,698
Granted Patent B2
US 12,601,698 · App. 18/104,508 · Granted Apr 14, 2026

Joint nanoscale three-dimensional imaging and chemical analysis

Inventors: Tom Wirtz (Grevenmacher, LU); Florian Vollnhals (Erlangen, DE)
Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
G01N23/2258
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Quick Facts
Patent No.
US 12,601,698
App. No.
18/104,508
Granted
Apr 14, 2026
Kind
B2
Abstract

A method for in-situ joint nanoscale three-dimensional imaging and chemical analysis of a sample. A single charged particle beam device is used for generating a sequence of two-dimensional nanoscale images of the sample, and for sputtering secondary ions from the sample, which are analysed using a secondary ion mass spectrometry device. The two-dimensional images are combined into a three-dimensional volume representation of the sample, the data of which is combined with the results of the chemical analysis.

Claims (20)

1 . A method for joint 3D imaging and chemical analysis of a sample comprising:

a) obtaining a sequence of two-dimensional images of said sample by a device, the sequence of two-dimensional images are based on secondary electron detection, the images of said sequence being taken from different viewing angles, and combining said two-dimensional images into a three-dimensional representation of the sample;

b) obtaining a representation of a chemical composition of said sample by the device, wherein obtaining the representation of the chemical composition is performed in-situ with obtaining the sequence of two-dimensional images of said sample, wherein during said step b), the sample is irradiated using a second primary charged particle beam, thereby releasing secondary ions from the sample, and wherein the second primary charged particle beam is an electron beam; and

c) mapping the representation of the chemical composition and the three-dimensional representation of the sample and recording a result in a memory element.

2 . The method according to claim 1 ,

wherein during said secondary electron imaging step a), the sample is irradiated using a first primary charged particle beam for taking a two-dimensional image, thereby releasing secondary electrons from the sample.

3 . The method according to claim 2 , wherein the first primary charged particle beam is an ion beam.

4 . The method according to claim 3 , wherein a first primary ion beam is an He+ beam, and wherein a second primary ion beam is an Ne+ beam.

5 . The method according to claim 2 , wherein the first primary charged particle beam is an electron beam.

6 . The method according to claim 1 , wherein during said secondary electron imaging step a), a relative position of said sample with respect to said secondary electron detection is changed.

7 . The method according to claim 6 , wherein said position is changed by changing an orientation of the sample with respect to the secondary electron detection.

8 . The method according to claim 1 , wherein step a) is performed prior to step b), or vice-versa.

9 . A device for performing joint 3D in-situ imaging and chemical analysis of a sample, the device comprising a memory storing instructions when executed by a processor cause the processor to:

a) obtain a sequence of two-dimensional images of said sample by the device, the sequence of two-dimensional images are based on secondary electron detection, the images of said sequence being taken from different viewing angles, and combine said two-dimensional images into a three-dimensional representation of the sample;

b) obtain a representation of a chemical composition of said sample by the device, wherein the representation of the chemical composition is obtained by in-situ performance with obtaining the sequence of two-dimensional images of said sample, wherein during said step b), the sample is irradiated using a second primary charged particle beam, to release secondary ions from the sample, and wherein the second primary charged particle beam is an electron beam; and

c) map the representation of the chemical composition and the three-dimensional representation of the sample and record a result in a memory element.

10 . The device according to claim 9 , wherein the device is configured to generate a first primary charged particle beam and a second primary charged particle beam.

11 . The device according to claim 10 , wherein an ion source is shared and utilized to generate the first primary charged particle beam and the second primary charged particle beam.

12 . The device according to claim 11 , wherein said ion source comprises a gas field ion source.

13 . The device according to claim 9 , wherein a sample holder comprises a rotatable stage for rotating the sample with respect to an emission axis utilized during generation of the first primary charged particle beam and the second primary charged particle beam.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 1, 2023
From: WIRTZ, TOM; VOLLNHALS, FLORIAN
To: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
Reel/Frame 063490/0567 →
Priority Claims (1)
LU LU100806 · May 30, 2018 · national
Continuity (2)
Continuation 17057961
Related Publication 20230175993A1 · Jun 8, 2023
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