Granted Patent B2

US 12,605,199 · App. 18/667,846 · Granted Apr 21, 2026

Inventors: Richard C. Pellegrino (Leesburg, VA); Rex Peters (San Jose, CA)

Assignee: Relievant Medsystems, Inc.

A61B18/14A61B17/025A61B18/1815A61F7/00A61M5/00A61N5/045A61N5/10A61N5/1049A61B2017/0256A61B2018/00339A61B2018/00577A61B2018/00982

Abstract

Claims (46)

1 . A system for treating back pain associated with a vertebral body of a patient, comprising:

an external energy source, wherein the external energy source is configured to be positioned at a location external to the body of the patient;

a linear drive coupled to the external energy source, wherein the linear drive is configured to translate the external energy source with respect to the patient in one or more axes;

a computer coupled to the external energy source and to the linear drive, the computer comprising a processor and a computer-readable memory, the computer-readable memory comprising instructions that, when executed, cause the processor to:

determine a target treatment site within or near the vertebral body based on acquired imaging data,

wherein the target treatment site corresponds to a location of a basivertebral nerve associated with pain in the vertebral body;

control the linear drive to position a focal point of the external energy source to substantially coincide with the target treatment site; and control the external energy source to deliver a treatment dose of therapeutic energy at said target treatment site,

wherein the treatment dose is configured to modulate the basivertebral nerve.

2 . The system as recited in claim 1 , further comprising an imaging source coupled to the computer for acquiring imaging data of the vertebral body.

3 . The system as recited in claim 2 , further comprising:

a support configured to restrain at least a portion of the patient to an external support, the support comprising a radiographically identifiable marker; and

wherein the executable program instructions, when executed, further cause the processor to:

control the imaging source for imaging the patient;

locate the radiographically identifiable marker within the acquired image; and assign an external reference point corresponding to the location of the radiographically identifiable marker,

wherein the external reference point is used as a base point for positioning the focal point of the external energy source at the target treatment site.

4 . The system as recited in claim 1 , further comprising a radial drive coupled to the external energy source, wherein the radial drive is configured to rotate the external energy source about the target treatment site during delivery of the treatment dose.

5 . The system as recited in claim 1 , wherein the external energy source comprises at least one radiation-emitting source having a common focal point.

6 . The system as recited in claim 1 , wherein the external energy source comprises at least one acoustic energy source having a common focal point.

7 . The system as recited in claim 1 , wherein the treatment dose is configured to permanently block conduction of the basivertebral nerve.

8 . The system as recited in claim 1 , wherein the treatment dose is configured to temporarily block conduction of the basivertebral nerve.

9 . The system as recited in claim 1 , wherein the treatment dose is configured to denervate the basivertebral nerve.

10 . The system as recited in claim 1 , wherein the treatment dose is configured to stimulate the basivertebral nerve.

11 . A radiotherapy system for treating back pain associated with a vertebral body of a patient, comprising:

an external radiation source, wherein the external radiation source is configured to be positioned at a location external to the body of the patient;

a linear drive coupled to the radiation source, the linear drive configured to translate the radiation source with respect to the patient in one or more axes;

a computer coupled to the radiation source and linear drive, the computer comprising a processor and a computer-readable memory, the computer-readable memory comprising instructions that, when executed, cause the processor to:

control the linear drive to position a focal point of the external radiation source to substantially coincide with a predetermined target treatment site,

wherein the target treatment site corresponds to a location of a basivertebral nerve associated with pain in the vertebral body; and control the external radiation source to deliver a treatment dose of therapeutic energy at said target treatment site,

wherein the treatment dose is configured to denervate the basivertebral nerve.

12 . The radiotherapy system as recited in claim 11 , further comprising an imaging source coupled to the computer for acquiring imaging data of the vertebra, wherein the executable program instructions are further configured to calculate the target treatment site based on acquired imaging data.

13 . The radiotherapy system as recited in claim 12 , further comprising:

a support configured to restrain at least a portion of the patient to an external support, the external support comprising a radiographically identifiable marker; and

wherein the executable program instructions that, when executed, further cause the processor to:

control the imaging source for imaging the patient;

locate the radiographically identifiable marker within the acquired image; and assign an external reference point corresponding to the location of the radiographically identifiable marker,

wherein the external reference point is used as a base point for positioning the focal point of the external radiation source at the target treatment site.

14 . A system for treating back pain associated with a vertebral body of a patient, the system comprising:

a delivery assembly configured to be percutaneously delivered to a treatment region adjacent the vertebral body, the delivery assembly comprising a catheter having one or more lumens; and

an energy delivery device configured to be advanced within one of the catheter lumens, the energy delivery device being sized to allow positioning of a distal end of the energy delivery device into a basivertebral foramen and having an energy delivery element configured to direct a field of energy into the basivertebral foramen to denervate the basivertebral nerve,

wherein the directed energy field is focused in a first direction into and confined within the basivertebral foramen.

15 . The system as recited in claim 14 , wherein the energy delivery element is configured to emit therapeutic energy radially outward from the distal end of the energy delivery device while substantially shielding energy delivery toward a proximal end of the energy delivery device.

16 . The system as recited in claim 15 , wherein the delivery assembly further comprises an imaging device to aid in visualization of the basivertebral foramen and delivery of the energy delivery device into the basivertebral foramen.

17 . The system as recited in claim 15 , wherein the delivery assembly further comprises an aspirating device to be delivered under the posterior longitudinal ligament via the one or more lumens of the catheter, and wherein the aspiration device is configured to dilate a space under the posterior longitudinal ligament to aid in visualization of the basivertebral foramen.

18 . The system as recited in claim 14 , wherein the delivery assembly further comprises a sensor that is configured to measure basivertebral nerve conduction and/or heating at the treatment region.

19 . The system as recited in claim 14 , wherein the system further comprises a fluid delivery catheter that is configured to be advanced within the one of the catheter lumens and dispense an agent to the treatment region.

20 . The system as recited in claim 14 , wherein the system further comprises a mechanical device that is configured to be advanced within the one of the catheter lumens and destroy and/or remove the basivertebral nerve.

Assignments (1)

Continuity (6)

References Cited (400)