IP Library › Granted Patent US 12,606,719
Granted Patent B2
US 12,606,719 · App. 16/483,428 · Granted Apr 21, 2026

Methods and compositions comprising biodegradable cyanoacrylates

Inventor: Kathy Lee-Sepsick (Suwanee, GA)
Assignee: Femasys Inc.
C09J4/00A61L24/0042A61L24/06C08F222/327A61L2430/36
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Quick Facts
Patent No.
US 12,606,719
App. No.
16/483,428
Granted
Apr 21, 2026
Kind
B2
Abstract

Disclosed herein are methods of making and using cyanoacrylate compositions comprising one or more cyanoacrylates, a high level of at least one stabilizing agent and at least one free-radical polymerization inhibitor. Methods disclosed comprise making such compositions and using such compositions, for example, for occluding conduits such as fallopian tubes.

Claims (16)

1 . A biodegradable cyanoacrylate composition, consisting essentially of,

a) a cyanoacrylate component consisting of methoxyisopropyl cyanoacrylate and methoxypropyl cyanoacrylate, wherein the cyanoacrylate component is 99 wt % or greater of the total weight of the biodegradable cyanoacrylate composition;

b) a stabilizer component of sulfur dioxide in a range from 600 ppm to 1500 ppm; and

c) a polymerization inhibitor component of butylated hydroxy anisole (BHA) in a range from 4000 to 7000 ppm,

wherein the viscosity of the composition is from about 10 cP to about 30 cP;

with a cure or setting time between 10 seconds and 30 seconds; and

wherein the composition fails to pass a Neutral Red cytotoxicity test (as measured by ISO 10993-5:2009) and passes genotoxicity testing (as measured by ISO 10993-3:2003).

2 . The biodegradable cyanoacrylate composition of claim 1 , further comprising a plasticizing agent, biocompatible agent, thickening agent, medicament, crosslinking agent, dye or pigment, preservative, antimicrobial agent, or polymerization initiator or accelerator.

3 . The biodegradable cyanoacrylate composition of claim 1 , wherein the composition is sterile.

4 . A biodegradable cyanoacrylate composition, comprising,

a. a cyanoacrylate component consisting of methoxyisopropyl cyanoacrylate and methoxypropyl cyanoacrylate, wherein the cyanoacrylate component is 99 wt % or greater of the total weight of the biodegradable cyanoacrylate composition;

b. a stabilizer component of sulfur dioxide in a range from 600 ppm to 1500 ppm; and

c. a polymerization inhibitor component of butylated hydroxy anisole (BHA) in a range from 4000 to 7000 ppm.

5 . The biodegradable cyanoacrylate composition of claim 4 , further comprising a plasticizing agent, biocompatible agent, thickening agent, medicament, crosslinking agent, dye or pigment, preservative, antimicrobial agent, or polymerization initiator or accelerator.

6 . The biodegradable cyanoacrylate composition of claim 4 , wherein the composition is sterile.

7 . The biodegradable cyanoacrylate composition of claim 5 , wherein the composition is sterile.

Assignments (2)
SECURITY INTEREST Recorded Nov 10, 2025
From: FEMASYS, INC.
To: POINTILLIST GLOBAL MACRO SERIES OF POINTILLIST PARTNERS LLC
Reel/Frame 072842/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2019
From: LEE-SEPSICK, KATHY
To: FEMASYS, INC.
Reel/Frame 050075/0240 →
Continuity (2)
Provisional Application 62456916 · Feb 9, 2017
Related Publication 20200010728A1 · Jan 9, 2020
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