IP Library › Granted Patent US 12,612,438
Granted Patent B2
US 12,612,438 · App. 17/478,926 · Granted Apr 28, 2026

Bistable type II opsins and uses thereof

Inventors: Ofer Yizhar (Rehovot, IL); Mathias Mahn (Rehovot, IL)
Assignee: Yeda Research and Development Co. Ltd.
C07K14/47A61N5/06A61P25/00A61K38/00A61N2005/0658
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Quick Facts
Patent No.
US 12,612,438
App. No.
17/478,926
Granted
Apr 28, 2026
Kind
B2
Abstract

Bistable type II opsins are provided. Accordingly, there is provided a polypeptide comprising a bistable type II opsin and a heterologous ER export signal and/or membrane trafficking signal. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.

Claims (5)

1 . A polynucleotide encoding a polypeptide comprising an OPN3 bistable type II opsin and ER export and membrane trafficking signals of a protein expressed in neuronal cells, said signals being heterologous to said OPN3 bistable type II opsin, wherein said ER export signal comprises SEQ ID NO: 2 and said membrane trafficking signal comprises SEQ ID NO: 1.

2 . The polynucleotide of claim 1 , wherein a nucleic acid sequence encoding said bistable type II opsin is codon optimized to heterologous expression.

3 . The polynucleotide of claim 1 , wherein said OPN3 is mosquito OPN3 (MosOpn3).

4 . A nucleic acid construct comprising the polynucleotide of claim 1 , and a regulatory element for directing expression of said polynucleotide in a cell.

5 . A cell comprising the polynucleotide of claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 9, 2021
From: YIZHAR, OFER; MAHN, MATHIAS
To: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Reel/Frame 058053/0517 →
Priority Claims (1)
IL 265486 · Mar 19, 2019 · national
Continuity (2)
Continuation PCTIL2020050330 · Mar 19, 2020
Related Publication 20210403518A1 · Dec 30, 2021
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