Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method
A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process, wherein the biodegradable fiber comprises 30 to 50 wt % of PLLGA resin and 70 to 50 wt % of β-TCP fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates, wherein the β-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the β-TCP fine particles are covered by the PLLGA resin so that the β-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and wherein the bone-regeneration material is sterilized by using radiation sterilization with gamma ray.
1 . A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process,
wherein the biodegradable fiber comprises 30 to 50 wt % of a copolymer of poly-L-lactic acid and polyglycolic acid (PLLGA) resin and 70 to 50 wt % of phase tricalcium phosphate (β-TCP) fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates,
wherein the β-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the β-TCP fine particles are covered by the PLLGA resin so that the β-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and
wherein the bone-regeneration material is has been sterilized by gamma radiation.
2 . The bone-regeneration material of claim 1 , wherein a weight ratio of lactic acid and glycolic acid in the PLLGA resin is approximately 85-50:15-50.
3 . The bone-regeneration material of claim 1 , wherein outer diameters of the β-TCP fine particles are in a range of 0.5 μm to 4 μm.
4 . The bone-regeneration material of claim 1 , wherein an outer diameter of the biodegradable fiber is 10 μm to 250 μm.
5 . The bone-regeneration material of claim 1 , wherein the bone-regeneration material formed of the biodegradable fiber is in a cotton-wool form having a bulk density of 0.01 to 0.1 g/cm 3 .
6 . The bone-regeneration material of claim 1 , wherein a molecular weight of the PLLGA resin is 60,000 to 600,000.