Hair loss therapy
This disclosure relates to a single pharmaceutical composition comprising a therapeutically effective or prophylactically effective amount of both minoxidil, or a similar antihypertensive vasodilator, and a 5-alpha reductase inhibitor (in some embodiments, the 5-alpha reductase inhibitor is finasteride) for treating or preventing hair loss in a subject. This disclosure also relates to a pharmaceutical package comprising a pharmaceutical composition for oral administration of a therapeutically effective or prophylactically effective amount of minoxidil, or a similar antihypertensive vasodilator, and a pharmaceutical composition for oral administration comprising a therapeutically effective or prophylactically effective amount of a 5-alpha reductase inhibitor (in some embodiments, the 5-alpha reductase inhibitor is finasteride) for treating or preventing hair loss in a subject. The disclosure further provides methods of treating or preventing hair loss in a subject using the disclosed compositions and packages.
1 . A pharmaceutical package for treating or preventing hair loss in a subject comprising a pharmaceutical composition for oral administration of a therapeutically effective or prophylactically effective amount of minoxidil, or a similar antihypertensive vasodilator, and a pharmaceutical composition for oral administration comprising a therapeutically effective or prophylactically effective amount of a 5-alpha reductase inhibitor.
2 . The pharmaceutical package of claim 1 , wherein the package comprises a pharmaceutical composition for oral administration of a therapeutically effective or prophylactically effective amount of minoxidil.
3 . The pharmaceutical package of claim 2 , wherein the 5-alpha reductase inhibitor is finasteride.
4 . The pharmaceutical package of claim 3 , wherein the pharmaceutical package is a blister pack.
5 . The pharmaceutical package of claim 3 , wherein either the pharmaceutical composition comprising minoxidil, or the pharmaceutical composition comprising finasteride is in liquid form.
6 . The pharmaceutical package of claim 3 , wherein both the pharmaceutical composition comprising minoxidil, or the pharmaceutical composition comprising finasteride are in liquid form.
7 . The pharmaceutical package of claim 3 , wherein the composition comprising finasteride comprises 1.5 mg to 5 mg finasteride.
8 . The pharmaceutical package of claim 3 , wherein the composition comprising minoxidil comprises 5 mg to 10 mg minoxidil.
9 . The pharmaceutical package of claim 3 , wherein the composition comprising minoxidil comprises 5 mg minoxidil or 10 mg minoxidil.
10 . A single pharmaceutical composition for oral administration comprising a therapeutically effective or prophylactically effective amount of minoxidil, or a similar antihypertensive vasodilator, and 1.5 mg to 5 mg finasteride for treating or preventing hair loss in a subject.
11 . The single composition of claim 10 comprising a therapeutically effective or prophylactically effective amount of minoxidil and 1.5 mg to 5 mg finasteride for treating or preventing hair loss in a subject.
12 . The single composition of claim 11 , wherein the composition comprising minoxidil comprises 5 mg to 10 mg minoxidil.
13 . The single composition of claim 11 , wherein the composition comprising minoxidil comprises 5 mg minoxidil or 10 mg minoxidil.
14 . The single composition of claim 11 , wherein the single composition results from mixing two pharmaceutical compositions in liquid form, a first pharmaceutical composition and a second pharmaceutical composition, together shortly before being administered to the subject, wherein the two compositions are contained in a pharmaceutical package for treating or preventing hair loss in the subject, said package comprising the first pharmaceutical composition for oral administration of a therapeutically effective or prophylactically effective amount of minoxidil, and the second pharmaceutical composition for oral administration comprising a therapeutically effective or prophylactically effective amount of 1.5 mg to 5 mg finasteride; wherein the pharmaceutical package is a blister pack.
15 . The single composition of claim 11 , wherein the pharmaceutical package is a blister pack.
16 . A method of treating or preventing hair loss in a subject in need thereof comprising administering by oral administration a single pharmaceutical composition of claim 11 to said subject.
17 . The method of claim 16 , wherein the subject is male.
18 . A method of treating or preventing hair loss in a subject in need thereof comprising administering to said subject by oral administration a first pharmaceutical composition of a therapeutically effective or prophylactically effective amount of minoxidil, or a similar antihypertensive vasodilator, and a second pharmaceutical composition for oral administration comprising a therapeutically effective or prophylactically effective amount of a 5-alpha reductase inhibitor, wherein the first pharmaceutical composition and the second pharmaceutical composition are contained in a pharmaceutical package of claim 2 .
19 . The method of claim 18 , wherein the first pharmaceutical composition comprises a therapeutically effective or prophylactically effective amount of minoxidil.
20 . The method of claim 18 , wherein the 5-alpha reductase inhibitor is finasteride.
21 . The method of claim 18 , wherein the subject is male.
22 . The method of claim 18 , further comprising administering to the subject by topical administration a first topical pharmaceutical composition comprising a therapeutically effective or prophylactically effective amount of minoxidil, or a similar antihypertensive vasodilator, and/or a second topical pharmaceutical composition comprising a therapeutically effective or prophylactically effective amount of a 5-alpha reductase inhibitor.
23 . The method of claims 22 , wherein the 5-alpha reductase inhibitor is finasteride.
24 . The method of claim 22 , wherein the first topical pharmaceutical composition comprises a therapeutically effective or prophylactically effective amount of minoxidil.