Compound for photothermal cancer therapy, composition including the same, and method for photothermal cancer therapy
View Patent ↗Provided are a new compound for photothermal cancer therapy, a composition including the same, and a method for photothermal cancer therapy, and more particularly, a compound that is an organic photosensitizer based on an indan structure, a nanoparticle as a self-assembly thereof, a composition including the same, and a method for photothermal therapy using the same.
1 . A compound represented by Chemical Formula 1:
wherein R 1 is selected from a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms, a substituted or unsubstituted cycloalkenyl group having 3 to 6 carbon atoms, a substituted or unsubstituted aryl group having 6 to 12 carbon atoms, a substituted or unsubstituted heteroaryl group having 5 to 12 carbon atoms, an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms, and an alkynyl group having 2 to 10 carbon atoms; and
wherein when R 1 is selected from a substituted cycloalkyl group having 3 to 6 carbon atoms, a substituted cycloalkenyl group having 3 to 6 carbon atoms, a substituted aryl group having 6 to 12 carbon atoms, and a substituted heteroaryl group having 5 to 12 carbon atoms, the substitution is selected from one of an alkyl having 1 to 5 carbon atoms, alkenyl having 2 to 5 carbon atoms, alkynyl having 2 to 5 carbon atoms, and a halogen atom.
2 . The compound of claim 1 , wherein the compound is provided in the form of an aggregate nanoparticle.
3 . The compound of claim 2 , wherein
the nanoparticle has a size of 500 nm or less, and
the nanoparticle emits heat at a temperature of 45° C. or higher by a light irradiation.
4 . The compound of claim 2 , wherein a photothermal conversion efficiency of the nanoparticle is 60% or higher.
5 . A composition comprising:
the compound represented by Chemical Formula 1 of claim 1 .
6 . The composition of claim 5 , wherein the composition is used for photothermal therapy, and emits thermal energy during a light irradiation to remove or kill target cells.
7 . The composition of claim 6 , wherein the target cells comprise cancer cells, tumor cells or hyperproliferative cells.
8 . The composition of claim 5 , further comprising:
water, an organic solvent, or both,
wherein the compound in the composition is included in an active ingredient content.
9 . A method for photothermal therapy, the method comprising:
contacting the composition of claim 5 with a target cell in vivo or ex vivo; and
irradiating light to a region of the target cell contacting the composition.
10 . The method of claim 9 , wherein the irradiating of the light comprises heating a target cell region to a temperature of 45° C. or more by irradiating a red light laser of 1 second or more and 1 W/cm 2 or more and removing or killing the target cell.
11 . The method of claim 9 , further comprising:
after the irradiating of the light, acquiring and analyzing an infrared thermal image of the target cell region.