IP Library › Granted Patent US 12,623,407
Granted Patent B2
US 12,623,407 · App. 18/643,669 · Granted May 12, 2026

Customized 3D printing lens design integrating visible-light optical coherence tomography

Inventors: Pengpeng Zhang (Evanston, IL); Raymond S. Fang (Evanston, IL); Cheng Sun (Evanston, IL); Hao F. Zhang (Evanston, IL)
Assignee: Northwestern University
B29C64/386B29C64/124B29C64/20B29C64/393B29D11/00038B29D11/00961B33Y10/00B33Y30/00B33Y50/00B33Y50/02B33Y80/00G02C7/027G02C7/04G02C7/047B29L2011/0041
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Quick Facts
Patent No.
US 12,623,407
App. No.
18/643,669
Filed
Apr 23, 2024
Granted
May 12, 2026
Kind
B2
Art Unit
1742
USPC
264/1.37
Abstract

Provided herein are systems and methods for additive manufacture of a customized ocular contact lens for a subject in a fast and convenient manner. In various aspects disclosed herein, methods disclosed herein provide for the imaging of the outer surface of a subject's cornea, designing a customized ocular contact lens based on the data from the imaging of the cornea, including determining anterior and posterior surfaces of the ocular contact lens, manufacturing the ocular contact lens using additive manufacturing, verifying the fit of the customized ocular contact lens on the subject's cornea, and verifying the optical power of the customized ocular contact lens. These features allow for the fast and convenient production of an ocular contact lens customized to a subject's cornea and manufactured to a specified optical power.

Claims (50)

1 . A method for additive manufacture of a customized ocular contact lens for a subject, the method comprising steps of:

imaging and acquiring image data of an outer surface of a cornea of the subject using visible-light optical coherence tomography (vis-OCT);

designing the customized ocular contact lens from the image data;

wherein the step of designing comprises:

processing the image data to generate a 3-D computational model of the outer surface of the cornea based on the acquired image data;

determining a posterior surface of the customized ocular contact lens using the 3-D computational model;

determining an anterior surface of the customized ocular contact lens to provide a selected optical power to the customized ocular contact lens; and

generating a 3-D printable data set of the customized ocular contact lens comprising the determined posterior surface and the determined anterior surface;

manufacturing the customized ocular contact lens using additive manufacturing based on the 3-D printable data set of the customized ocular contact lens; and

verifying a shape of the manufactured customized ocular contact lens by imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens using visible-light optical coherence tomography.

2 . The method of claim 1 , wherein imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens comprises imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens when the manufactured customized ocular contact lens is wet.

3 . The method of claim 1 , wherein imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens comprises imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens when the manufactured customized ocular contact lens is suspended in a liquid, wherein the liquid is water, oil, or diluted intralipid.

4 . The method of claim 1 , wherein imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens comprises imaging the anterior surface and the posterior surface of the manufactured customized ocular contact lens when the manufactured customized ocular contact lens is positioned on and in contact with the cornea of the subject.

5 . The method of claim 1 , wherein at least one of the steps of processing the image data, determining the posterior surface, determining the anterior surface, generating the 3-D printable data set, and manufacturing the customized ocular contact lens is performed computationally and automatically without human intervention.

6 . The method of claim 1 , wherein each of the steps of processing the image data, determining the posterior surface, determining the anterior surface, generating the 3-D printable data set, and manufacturing the customized ocular contact lens is performed computationally and automatically without human intervention.

7 . The method of claim 1 , wherein sharp corners are computationally and automatically removed from the 3-D printable data set.

8 . The method of claim 1 , wherein processing the image data to generate a 3-D computational model of the outer surface of the cornea comprises:

translating the image data into binarized images;

using a Sobel edge detection function to delineate the cornea from the binarized images; and

using a surface fit function to generate the 3-D computational model of the outer surface of the cornea.

9 . The method of claim 1 , wherein the selected optical power is selected from the range of −6D to +6D.

10 . The method of claim 1 , wherein the posterior surface is determined to have a shape complementary to a shape of the 3-D computational model.

11 . The method of claim 1 , wherein a best-fit spherical shape is generated based on the 3-D computational model, and the best-fit spherical shape is used to design the customized ocular contact lens; or wherein the anterior surface is determined using the lensmaker equation.

12 . The method of claim 1 , wherein the step of designing further comprises determining one or more edge surfaces connecting the anterior surface with the posterior surface.

13 . The method of claim 1 , wherein the additive manufacturing comprises projection micro-stereolithography (PuSL), micro-continuous liquid interface production (μCLIP), digital light processing (DLP), or any combination thereof.

14 . The method of claim 1 , wherein the additive manufacturing manufactures the customized ocular contact lens in a vertical orientation, such that each of a majority of printable layers of the customized ocular contact lens comprises a portion of both the posterior surface and the anterior surface.

15 . The method of claim 1 , wherein the entire method is completed within an hour or less.

16 . The method of claim 1 , wherein the steps of processing the image data, determining the posterior surface, determining the anterior surface, generating the 3-D printable data set, and manufacturing the customized ocular contact lens are completed within a total time of 30 minutes or less.

17 . The method of claim 1 , wherein the additive manufacturing has a voxel resolution of 6 μm or less.

18 . The method of claim 1 , wherein the customized ocular contact lens has a diameter selected from the range of 3 mm to 15 mm; wherein the customized ocular contact lens has a surface roughness of 2 nm of less; wherein the customized ocular contact lens has a thickness selected from the range of 300 μm to 700 μm; or wherein the customized ocular contact lens has a tolerance in thickness of less then 5%.

19 . The method of claim 1 , wherein the customized ocular contact lens has an absorbance of less than 1% at wavelengths selected from the range of 400 nm to 800 nm.

20 . The method of claim 1 , wherein the customized ocular contact lens has a refractive index between 1.4 and 1.6 for wavelengths selected from the range of 400 nm to 800 nm.

21 . The method of claim 1 , wherein the customized ocular contact lens is hydrophilic such that a contact angle of deionized water thereon is selected from the range of 35° to 50°.

22 . The method of claim 1 , wherein the manufactured customized ocular contact lens has a composition comprising one or more of methacrylate polymers, poly(ethylene glycol) diacrylate, trimethylolpropane ethoxylate triacrylate, ethylene glycol dimethacrylate, avobenzone, Irgacure 819 (phenylbis(2,4,6-trimethylbenzoyl) (phosphine oxide)), or any combination thereof.

23 . The method of claim 1 , wherein the manufactured customized ocular contact lens is characterized by:

an ultimate tensile strength (UTS) selected from the range of 6 MPa to 900 MPa;

a maximum elongation at failure selected from the range of 8% to 175%;

or any combination thereof.

24 . A system for additive manufacture of a customized ocular contact lens, the system comprising:

a visible-light optical coherence tomography (vis-OCT) apparatus configured to perform vis-OCT on a cornea of a subject;

an additive manufacturing apparatus configured to manufacture the customized ocular contact lens; and

a non-transitory computer readable medium having stored thereon computer implementable instructions executable by a processor in a computing device configured to:

image and acquire image data of an outer surface of the cornea of the subject using the vis-OCT apparatus;

process the image data to generate a 3-D computational model of the outer surface of the cornea based on the acquired image data;

determine a posterior surface of the customized ocular contact lens using the 3-D computational model;

determine an anterior surface of the customized ocular contact lens to provide a selected optical power to the customized ocular contact lens;

generate a 3-D printable data set of the customized ocular contact lens comprising the determined posterior surface and the determined anterior surface;

manufacture the customized ocular contact lens based on the 3-D printable data set of the customized ocular contact lens using the additive manufacturing apparatus; and

verify a shape of the manufactured customized ocular contact lens using the visible-light optical coherency tomography apparatus to image the anterior surface and the posterior surface of the manufactured customized ocular contact lens.

25 . The system of claim 24 , wherein the additive manufacturing apparatus comprises an apparatus for micro-continuous liquid interface production (μCLIP).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2024
From: ZHANG, PENGPENG; FANG, RAYMOND S.; SUN, CHENG; ZHANG, HAO F.
To: NORTHWESTERN UNIVERSITY
Reel/Frame 067376/0655 →
Continuity (2)
Provisional Application 63461779 · Apr 25, 2023
Related Publication 20240359407A1 · Oct 31, 2024
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