Granted Patent B2

US 12,624,015 · App. 17/622,210 · Granted May 12, 2026

Inventors: Aliasger K. Salem (Coralville, IA); Somaya Ali Mohammed Elsaid Abdelrahman (Redwood City, CA)

Assignee: University of Iowa Research Foundation

C07D333/66A61K9/0019A61K9/1641A61K9/5161A61K31/38A61P35/00

Abstract

Claims (11)

1 . A compound of formula (I):

or a pharmaceutically acceptable salt thereof,

wherein R is hydrogen, halo, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, substituted alkyl, carbocycle or heterocycle;

wherein X is CONH(C1-C6) alkyl; and

wherein R 1 and R 2 independently are alkyl, alkenyl, alkynyl, alkoxy, or substituted alkyl or R 1 and R 2 together form a C6 or C7 ring.

2 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R is halo, (C1-C6)alkyl, substituted (C1-C6)alkyl, or C5-C7 carbocycle.

3 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 together form a C6 ring.

4 . The compound of claim 1 which is:

or a pharmaceutically acceptable salt thereof.

5 . A composition having nanoparticles comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof.

6 . The composition of claim 5 , wherein the nanoparticles comprise a polymer comprising lactic acid, glycolic acid, caproic acid, a polyanhydride, or a combination thereof.

Assignments (1)

Continuity (2)

References Cited (400)