IP Library › Granted Patent US 12,628,817
Granted Patent B2
US 12,628,817 · App. 18/322,906 · Granted May 19, 2026

Method for increasing the lifespan and motility of animal sperm using an inhibitor of Slo3 potassium channel

Inventors: Christophe Arnoult (Saint Etienne de Crossey, FR); Eric Schmitt (Villaines-la-Juhel, FR); Guillaume Martinez (Poisat, FR); Jessica Escoffier (Saint Etienne de Crossey, FR)
Assignees: IMV TECHNOLOGIES; UNIVERSITE GRENOBLE ALPES; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); SWISSGENETICS
A01N1/126A01N1/125A61D19/024A61D19/027A61K31/14A61K31/4748
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Quick Facts
Patent No.
US 12,628,817
App. No.
18/322,906
Granted
May 19, 2026
Kind
B2
Abstract

The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel. The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument. Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

Claims (10)

1 . An artificial insemination instrument for use in artificial insemination of an animal, comprising:

an artificial insemination straw comprising:

a substantially cylindrical tube; and

a liquid-tight stopper arranged within the substantially cylindrical tube; and

animal sperm within the substantially cylindrical tube, between the liquid-tight stopper and an end of the tube, in contact with an inhibitor of Slo3 potassium channel that improves ability of the animal sperm to fertilize said animal.

2 . An artificial insemination instrument according to claim 1 , wherein the artificial insemination instrument is a semen straw for cryopreservation.

3 . A method for increasing life span or motility of animal sperm using an inhibitor of Slo3 potassium channel, comprising:

providing an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with the inhibitor of Slo3 potassium channel; and

inseminating said animal using the artificial insemination instrument;

wherein the inhibitor of Slo3 potassium channel improves ability of the animal sperm to fertilize said animal.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2023
From: ARNOULT, CHRISTOPHE; SCHMITT, ERIC; MARTINEZ, GUILLAUME; ESCOFFIER, JESSICA
To: IMV TECHNOLOGIES; UNIVERSITE GRENOBLE ALPES; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); SWISSGENETICS
Reel/Frame 063748/0944 →
Priority Claims (1)
EP 17306818 · Dec 18, 2017 · regional
Continuity (2)
Division 16955539
Related Publication 20230292743A1 · Sep 21, 2023
References Cited (18)
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