Probiotic composition for treatment of oral
The present invention relates to a Lactobacillus rhamnosus strain. In particular, the present invention relates to a composition comprising a Lactobacillus rhamnosus optionally in combination with a further lactobacilli and the use of the same in the treatment, prevention or alleviation of candidiasis.
1 . A Lactobacillus rhamnosus strain ERB 36 having accession number DSM 32992, wherein said strain is in a lyophilized, spray dried, vacuum dried or microencapsulated form or any combination thereof.
2 . A culture broth comprising Lactobacillus rhamnosus strain ERB 36 having accession number DSM 32992, wherein said broth is in a lyophilized, spray dried, vacuum dried or microencapsulated form or any combination thereof.
3 . The culture broth according to claim 2 , further comprising at least one lactobacilli sp. selected from the group consisting of Lactobacillus rhamnosus strain ERB18 having accession number DSM 32991, Lactobacillus rhamnosus strain PB01 having accession number DSM 14870 and Lactobacillus curvatus EB10 having accession number DSM 32307.
4 . A composition comprising Lactobacillus rhamnosus strain ERB 36 having accession number DSM 32992, wherein said strain is in a lyophilized, spray dried, vacuum dried or microencapsulated form or any combination thereof, wherein said composition is in the form of a tablet, a capsule, an effervescent tablet, an effervescent powder, a microencapsulated product, a gel or a cream.
5 . The composition according to claim 4 , comprising at least one further lactobacilli sp. selected from the group consisting of Lactobacillus rhamnosus strain ERB18 having accession number DSM 32991, Lactobacillus rhamnosus strain PB01 having accession number DSM 14870 and Lactobacillus curvatus EB10 having accession number DSM 32307.
6 . The composition according to claim 4 , wherein said composition comprises from 10 5 to 10 13 CFU of lactobacilli per gram of said composition.
7 . The composition according to claim 4 , further comprising a bulking agent, a binder, a glazing agent, a sweetener or a flavour.
8 . A method comprising administering to a subject in need of a probiotic:
a) Lactobacillus rhamnosus strain ERB 36 having accession number DSM 32992, wherein said strain is in a lyophilized, spray dried, vacuum dried or microencapsulated form or any combination thereof; or,
b) the composition of claim 4 .
9 . A method of treating or alleviating candidiasis in a subject, comprising administering Lactobacillus rhamnosus strain ERB 36 having accession number DSM 32992, wherein said strain is in a lyophilized, spray dried, vacuum dried or microencapsulated form or any combination thereof to a subject in need thereof.
10 . The method according to claim 9 , wherein said candidiasis is oral or vaginal candidiasis.
11 . The method of claim 9 , wherein said candidiasis is caused by a Candida spp. selected from the group consisting of Candida glabrata, Candida krusei, Candida tropicalis, Candida dubliniensis, Candida parapsilosis , and Candida albicans.
12 . A container containing Lactobacillus rhamnosus strain ERB 36 having accession number DSM 32992, wherein said strain is in a lyophilized, spray dried, vacuum dried or microencapsulated form or any combination thereof, or the composition according to claim 4 .
13 . The container according to claim 12 , wherein said container is a blister pack, stick, bag, pouch, sachet, or capsule.
14 . A method of treating or alleviating candidiasis in a subject, comprising administering the composition of claim 4 to a subject in need thereof.
15 . The composition according to claim 4 , comprising at least one further lactobacilli sp. selected from the group consisting of Lactobacillus rhamnosus strain ERB18 having accession number DSM 32991, Lactobacillus rhamnosus strain PB01 having accession number DSM 14870 and Lactobacillus curvatus EB10 having accession number DSM 32307.
16 . A method of treating or alleviating candidiasis in a subject, comprising administering the composition of claim 15 to a subject in need thereof.