IP Library Granted Patent US 12,638,531
Granted Patent B2
US 12,638,531 · App. 18/665,093 · Granted May 26, 2026

System and method for RF based frequency encoding using injection transformers for simultaneous transmit and receive

Inventors: Sai Abitha Srinivas (Nashville, TN); William A. Grissom (Shaker Heights, OH); Mark A. Griswold (Shaker Heights, OH)
Assignees: Case Western Reserve University; Vanderbilt University
G01R33/4831G01R33/3415G01R33/5608G01R33/583
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,638,531
App. No.
18/665,093
Granted
May 26, 2026
Kind
B2
Abstract

A system for RF based frequency encoding utilizing a Bloch-Siegert shift, includes a controller, an RF encoding system, and an injection transformer simultaneous transmit and receive filter. The controller generates RF excitation pulses, RF based frequency encoding pulses, and a cancellation signal. The RF encoding system includes one or more RF coils configured to transmit the RF excitation pulses and RF based frequency encoding pulses, and to receive an MR signal from the subject where the MR signal includes a leakage signal induced by the RF based frequency encoding pulses. The injection transformer simultaneous transmit and receive filter is in signal communication with the controller and the RF encoding system. The injection transformer simultaneous transmit receive filter is configured to receive the cancellation signal, the MR signal including the leakage signal, and to cancel the leakage signal from the received MR signal to generate a filtered MR signal.

Claims (31)

1 . A system for RF based frequency encoding utilizing a Bloch-Siegert shift, the system comprising:

a controller configured to generate RF excitation pulses, RF based frequency encoding pulses and a cancellation signal;

an RF encoding system in signal communication with the controller and comprising one or more RF coils configured to transmit the RF excitation pulses and RF based frequency encoding pulses, and to receive an MR signal from the subject wherein the MR signal includes a leakage signal induced by the RF based frequency encoding pulses; and

an injection transformer simultaneous transmit and receive filter in signal communication with the controller and the RF encoding system, the injection transformer simultaneous transmit receive filter configured to receive the cancellation signal, the MR signal including the leakage signal, and to cancel the leakage signal from the received MR signal to generate a filtered MR signal.

2 . A method for generating an image of a subject using RF based frequency encoding utilizing a Bloch-Siegert shift, the method comprising:

for each of a plurality of predetermined portions of k-space:

performing an imaging module of a RF based frequency encoding pulse sequence to obtain imaging MR data, the imaging module comprising an RF excitation pulse and one or more RF frequency encoding pulses;

performing a calibration module of the RF based frequency encoding pulse sequence to obtain calibration MR data, the calibration module performed without the RF excitation pulse and comprising the one or more RF frequency encoding pulses; and

determining frequency encoded MR data by subtracting the calibration MR data from the imaging MR data;

storing the determined frequency encoded MR data for each predetermined portion of k-space; and

generating an image of the subject based on the frequency encoded MR data for the plurality of predetermined portions of k-space.

3 . The system according to claim 1 , wherein an amplitude of the cancellation signal is the same as an amplitude of the leakage signal and a phase of the cancellation signal is the opposite of a phase of the leakage signal, and wherein the injection transformer simultaneous transmit receive filter comprises:

a first primary winding configured to receive the MR signal including the leakage signal from the RF encoding system;

a second primary winding configured to receive the cancellation signal from the controller; and

a secondary winding wherein the MR signal without the leakage signal is induced in the secondary winding.

4 . The system according to claim 1 , further comprising a TR switch coupled between the controller and the injection transformer simultaneous transmit and receive filter.

5 . The system according to claim 1 , further comprising a pre-amplifier coupled between the injection transformer simultaneous transmit and receive filter and the controller.

6 . The system according to claim 1 , further comprising a power amplifier coupled between the controller and the RF encoding system.

7 . The system according to claim 1 , wherein the RF encoding system further comprises an RF shield.

8 . The system according to claim 1 , wherein an amplitude and a phase of the cancellation signal is calibrated to produce a maximum cancellation of the leakage signal.

9 . The system according to claim 1 , wherein a shape of the RF based frequency encoding pulses is calibrated to match a shape of the cancellation signal.

10 . The system according to claim 1 , wherein the one or more RF coils of the RF encoding system comprises a transmit coil and a receive coil and the transmit coil and the receive coil are decoupled.

11 . The system according to claim 1 , wherein the one or more RF coils of the RF encoding system comprising an RF coil including a transmit port and a receive port, and the transmit port and the receive port are decoupled.

12 . The system according to claim 1 , wherein the receive coil is a single loop coil.

13 . The system according to claim 1 , wherein the RF based frequency encoding pulses are flat amplitude modulated (AM) and frequency modulated (FM) waveforms.

14 . The method according to claim 2 , wherein the one or more RF frequency encoding pulses comprises a pre-phasor RF frequency encoding pulse and a readout RF frequency encoding pulse.

15 . The method according to claim 2 , wherein the RF based frequency encoding pulses are flat amplitude modulated (AM) and frequency modulated (FM) waveforms.

16 . The method according to claim 2 , wherein the RF based frequency encoding pulses are time-varying.

17 . The system according to claim 2 , wherein the first primary winding, the second primary winding and the secondary winding are formed using Litz wire and a low-loss core.

18 . The system according to claim 10 , wherein the transmit coil and the receive coil are decoupled using one or more of geometric decoupling or electrical decoupling.

19 . The system according to claim 10 , wherein the transmit coil comprises a plurality of bucking coils positioned on an end of the transmit coil.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2025
From: SRINIVAS, SAI ABITHA
To: VANDERBILT UNIVERSITY
Reel/Frame 070191/0461 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2025
From: GRISSOM, WILLIAM A.; GRISWOLD, MARK A.
To: CASE WESTERN RESERVE UNIVERSITY
Reel/Frame 070191/0498 →
Continuity (2)
Provisional Application 63502296 · May 15, 2023
Related Publication 20240385268A1 · Nov 21, 2024
References Cited (26)
US 9625551B2 · Ozen et al. · 2017 [cited by applicant]
US 9995808B2 · Grissom et al. · 2018 [cited by applicant]
US 10627463B2 · Schillak et al. · 2020 [cited by applicant]
US 20150253403A1 · Grissom · 2015 [cited by examiner]
US 20170180166A1 · Zhou · 2017 [cited by examiner]
US 20240385268A1 · Srinivas · 2024 [cited by examiner]
Bloch, F., and A. Siegert. “Magnetic resonance for nonrotating fields.” Physical Review 57.6 (1940): 522. [cited by applicant]
Cao, Zhipeng, Eduard Y. Chekmenev, and William A. Grissom. “Frequency encoding by Bloch-Siegert shift.” Proc. 22nd Annu. Meet. Int. Soc. Magn. Res. Med 4220 (2014). [cited by applicant]
Ha, Yonghyun, et al. “Design of frequency division duplex RF system for frequency encoding using Bloch-Siegert shift.” Proc. 29th Annu. Meet. Int. Soc. Magn. Res. Med 0749 (2020). [cited by applicant]
Hasselwander, Christopher J., and William A. Grissom. “Bloch-Siegert phase-encoded MRI with a single RF coil and frequency-swept pulses.” Proceedings of the 25th Annual Meeting of ISMRM, Honolulu, HI. 5047 (2017). [cited by applicant]
Hoult, D. I. “Rotating frame zeugmatography.” Journal of Magnetic Resonance (1969) 33.1 (1979): 183-197. [cited by applicant]
Jankiewicz, Marcin, John C. Gore, and William A. Grissom. “Improved encoding pulses for Bloch-Siegert B1+ mapping.” Journal of Magnetic Resonance 226 (2013): 79-87. [cited by applicant]
Kartäusch, Ralf, et al. “Spatial phase encoding exploiting the Bloch-Siegert shift effect.” Magnetic Resonance Materials in Physics, Biology and Medicine 27 (2014): 363-371. [cited by applicant]
Martin, Jonathan B., et al. “Selective excitation localized by the Bloch-Siegert shift and a B 1+ gradient.” Magnetic resonance in medicine 88.3 (2022): 1081-1097. [cited by applicant]
Metz, Kenneth R., et al. “Rapid rotating-frame imaging using an RF pulse train (RIPT).” Journal of Magnetic Resonance, Series B 103.2 (1994): 152-161. [cited by applicant]
Ozen, Ali Caglar, and Atalar Ergin. “Active decoupling of RF coils: application to 3D MRI with concurrent excitation and acquisition.” Proceedings of International Society for Magnetic Resonance in Medicine. 2015. [cited by applicant]
Sacolick, Laura I., et al. “B1 mapping by Bloch-Siegert shift.” Magnetic resonance in medicine 63.5 (2010): 1315-1322. [cited by applicant]
Selvaganesan, Kartiga, et al. “Nonlinear projection imaging with the Bloch-Siegert shift in an inhomogeneous B 0 at low-field.” Proc. 30th Annu. Meet. Int. Soc. Magn. Res. Med 0899 (2021). [cited by applicant]
Sharp, Jonathan C., and Scott B. King. “MRI using radiofrequency magnetic field phase gradients.” Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine 63.1 … [cited by applicant]
Sohn, Sung-Min, et al. “In vivo MR imaging with simultaneous RF transmission and reception.” Magnetic resonance in medicine 76.6 (2016): 1932-1938. [cited by applicant]
Srinivas, Sai Abitha, et al. “EMI-Suppressed Gradient-Free Phase-Encoded Imaging at 47.5 mT Using an Optimized Square-Root Solenoid for Encoding and a Saddle Coil for Imaging.” Proc. 31st Annu. Meet. Int. Soc. Magn. Res… [cited by applicant]
Srinivas, Sai Abitha. Gradient-Free Low-Field MRI using the Bloch-Siegert Shift for RF Spatial Encoding. Diss. 2023. [cited by applicant]
Straney, Don, Clarissa Zimmerman Cooley, and Matthew S. Rosen. “An improved power handling active transmit/receive switch for low field MRI using reed relays.” Proceedings of the 25th Annual Meeting of ISMRM, London, UK… [cited by applicant]
Torres, Efraín, et al. “B 1-gradient-based MRI using frequency-modulated Rabi-encoded echoes.” Magnetic resonance in medicine 87.2 (2022): 674-685. [cited by applicant]
Trushkin, D. V., O. A. Shushakov, and A. V. Legchenko. “The potential of a noise-reducing antenna for surface NMR ground-water surveys in the earth's magnetic field.” Geophysical Prospecting 42.8 (1994): 855-862. [cited by applicant]
Wilcox, Matthew, et al. “A Linear Gradient Solenoid for Slice-Selective Brain Imaging using B1+-Selective RF Pulses.” Proc. 30th Annu. Meet. Int. Soc. Magn. Res. Med 4035 (2021). [cited by applicant]