Low coherence interferometry on compositions manufactured using thermal manufacturing processes
A method of determining information indicative of a material attribute of a composition, wherein the method comprises manufacturing the composition using a thermal manufacturing process, detecting detection data from the composition by low coherence interferometry during the manufacturing, in particular during said thermal manufacturing process, and determining the information based on the detected detection data.
1 . A method of determining information indicative of a material attribute of a composition, wherein the method comprises:
manufacturing the composition using a thermal manufacturing process;
wherein said manufacturing the composition comprises manufacturing the composition by extruding a core and coating the core, and further comprises coating the core by one of the group consisting of carrying out a further extrusion, and immersing in a coating bath;
wherein the composition is a pharmaceutical composition and/or wherein the composition is configured as an intravaginal ring for contraception;
wherein the method comprises continuously detecting detection data and continuously determining the information of an endless strand constituting the composition and being formed continuously by the thermal manufacturing process;
detecting detection data from the composition by low coherence interferometry during the thermal manufacturing process;
determining the information based on the detected detection data,
wherein the information are indicative of at least one material attribute of a group consisting of a roughness of an exterior surface of the composition, a roughness between a core and a coating of the composition, a refraction index of at least part of the composition, information concerning an inclusion of the composition, and information concerning a porosity of the composition;
determining the information indicative of a material attribute of the composition during the thermal manufacturing process in real time;
wherein determining the information indicative of a material attribute of the composition comprises indicating anomalies or deviations from a predefined specification; and
adapting the thermal manufacturing process in real time to continue the production of compositions in compliance with the predefined specification while the composition is produced by thermal manufacturing.
2 . The method according to claim 1 , wherein the thermal manufacturing process involves a phase transition of material of the composition, wherein the phase transition is between a solid phase and a liquid phase or viscous phase.
3 . The method according to claim 1 , wherein the method comprises manufacturing the composition by a thermal manufacturing process which comprises at least one of the group consisting of extrusion, co-extrusion, molding, or injection molding.
4 . The method according to claim 1 , wherein the method comprises manufacturing the composition by forming a plurality of coating layers on the core.
5 . The method according to claim 1 , wherein the method comprises bringing the composition in a field of view of a detection probe detecting the detection data during said thermal manufacturing process.
6 . The method according to claim 1 , wherein said coating the core by immersing in a coating bath comprises immersing in a cooling bath.
7 . The method according to claim 1 , wherein the method comprises determining information indicative of a material attribute of a polymeric structure of the composition.
8 . The method according to claim 1 , wherein the method comprises determining information indicative of a material attribute of the composition without destruction of the composition.
9 . The method according to claim 1 , wherein the method comprises continuously determining information indicative of a material attribute of compositions being continuously manufactured during the detecting.
10 . The method according to claim 1 , wherein the method comprises determining information indicative of a material attribute of the composition around more than half of a circumference of the composition, or along an entire circumference of the composition.
11 . The method according to claim 1 , comprising at least one of the following features:
wherein the method comprises determining the information by carrying out image recognition;
wherein the method comprises determining information indicative of a quality of the composition based on the determined information indicative of the material attribute of the composition;
wherein the method comprises manufacturing a composition which is configured as an intravaginal ring for contraception;
wherein the pharmaceutical composition is in a pharmaceutical dosage form;
wherein the method comprises detecting the detection data by optical coherence tomography; and
wherein the method comprises determining the information for at least one composition of the group consisting of pellets, tablets, strands, films, patches, film foils, rings, a core with a coating, a core with a plurality of coating layers, a core without coating, and a carrier in form of a preferably transparent polymer in which a molecularly dispersed drug preparation is embedded.
12 . An apparatus for manufacturing a composition and for determining information indicative of a material attribute of the manufactured composition, wherein the apparatus comprises:
a manufacturing device configured for manufacturing the composition using a thermal manufacturing process;
wherein the manufacturing device comprises means for manufacturing the composition by extruding a core and coating the core, and further comprises means for coating the core by one of the group consisting of carrying out a further extrusion, and immersing in a coating bath;
wherein the manufacturing device comprises means for continuously detecting detection data and continuously determining the information of an endless strand constituting the composition and being formed continuously by the thermal manufacturing process;
a detection probe configured for detecting detection data from the composition during said thermal manufacturing process, by low coherence interferometry; and
a processor configured for determining the information based on the detected detection data,
wherein the information are indicative of at least one material attribute of a group consisting of a roughness of an exterior surface of the composition, a roughness between a core and a coating of the composition, a refraction index of at least part of the composition, information concerning an inclusion of the composition, and information concerning a porosity of the composition;
determining the information indicative of a material attribute of the composition during the thermal manufacturing process in real time;
wherein determining the information indicative of a material attribute of the composition comprises indicating anomalies or deviations from a predefined specification; and
adapting the thermal manufacturing process in real time to continue the production of compositions in compliance with the predefined specification while the composition is produced by thermal manufacturing.
13 . The apparatus according to claim 12 , wherein the apparatus comprises at least one further detection probe, wherein the detection probes are arranged at different angular positions around a circumference of the manufactured composition.
14 . The apparatus according to claim 13 , wherein the detection probe and the at least one further detection probe are stationary.
15 . The apparatus according to claim 12 , comprising a motion mechanism configured for moving the detection probe and the manufactured composition relative to each other.
16 . The apparatus according to claim 15 , comprising one of the following features:
the motion mechanism is configured for rotating the composition while the detection probe is stationary;
the motion mechanism is configured for rotating the detection probe while the composition is stationary.
17 . The apparatus according to claim 12 , wherein the apparatus comprises a reflector configured for reflecting electromagnetic radiation from a surface portion of the composition to the detection probe.
18 . A method of determining information indicative of a material attribute of a composition, wherein the method comprises:
manufacturing the composition using a thermal manufacturing process;
wherein said manufacturing the composition comprises manufacturing the composition by extruding a core and coating the core, and further comprises coating the core by one of the group consisting of carrying out a further extrusion, and immersing in a coating bath;
wherein the composition is a pharmaceutical composition and/or wherein the composition is configured as an intravaginal ring for contraception;
wherein the method comprises continuously detecting detection data and continuously determining the information of an endless strand constituting the composition and being formed continuously by the thermal manufacturing process;
detecting detection data from the composition by low coherence interferometry during the thermal manufacturing process; and
determining the information based on the detected detection data;
determining the information indicative of a material attribute of the composition during the thermal manufacturing process in real time;
wherein determining the information indicative of a material attribute of the composition comprises indicating anomalies or deviations from a predefined specification; and
adapting the thermal manufacturing process in real time to continue the production of compositions in compliance with the predefined specification while the composition is produced by thermal manufacturing.