IP Library › Granted Patent US 12,653,186

Granted Patent B2

US 12,653,186 · App. 18/250,589 · Granted Jun 16, 2026

[(1-phenyl-5-(heteroaryl)-1H-1,2,4-triazol-3-yl)oxy] acetic acid derivatives as safeners for the protection of useful plants and crop plants

Inventors: Thomas Müller (Frankfurt, DE); Anna Maria Reingruber (Heppenheim, DE); Jens Frackenpohl (Frankfurt, DE); Hendrik Helmke (Liederbach, DE); Jan Dittgen (Frankfurt, DE)

Assignee: BAYER AKTIENGESELLSCHAFT

A01N25/32 C07D401/04 C07D405/14

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Patent No.: US 12,653,186
App. No.: 18/250,589
Granted: Jun 16, 2026
Kind: B2

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Abstract

The present invention relates to crop protection compounds and to compositions which comprise specific compounds as safeners for reducing phytotoxic effects of agrochemicals, especially herbicides. The invention relates more particularly to certain [(1-phenyl-5-(heteroaryl)-1H-1,2,4-triazol-3-yl)oxy]acetic acid derivatives of the general formula (I) and their salts, to processes for preparing them and to their use as crop protection compounds (safeners).

Claims (70)

1 . A compound of general formula (I) or salt thereof

in which

R 1 is heteroaryl, where the heteroaryl radical is unsubstituted or substituted by halogen, cyano, nitro, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 1 -C 6 )alkoxy or (C 1 -C 6 )alkylS(O) p , where the latter seven radicals are unsubstituted or are substituted by one or more radicals from the group of halogen, cyano, (C 1 -C 6 )alkoxy and (C 1 -C 6 )alkylS(O) p ,

R 2 is hydrogen, halogen, cyano, nitro, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkenyl, (C 1 -C 6 )alkoxy or (C 1 -C 6 )alkylS(O) p , where the latter seven radicals are unsubstituted or are substituted by one or more radicals from the group of halogen, cyano, (C 1 -C 6 )alkoxy and (C 1 -C 6 )alkylS(O) p ,

R 3 is hydrogen or (C 1 -C 6 )alkyl,

R 4 is hydrogen, (C 1 -C 18 )alkyl, (C 1 -C 18 )haloalkyl, (C 1 -C 18 )cyanoalkyl, (C 2 -C 18 )alkenyl, (C 2 -C 18 )alkynyl, (C 3 -C 12 )cycloalkyl, (C 3 -C 12 )cycloalkenyl, aryl, heteroaryl, (C 1 -C 18 )alkoxy-(C 1 -C 18 )alkyl, (C 1 -C 18 )haloalkoxy-(C 1 -C 18 )alkyl, (C 1 -C 18 )alkoxy-(C 1 -C 18 )haloalkyl, (C 1 -C 18 )alkylthio-(C 1 -C 18 )alkyl, (C 1 -C 18 )haloalkylthio-(C 1 -C 18 )alkyl, (C 2 -C 18 )haloalkenyl, (C 2 -C 18 )haloalkynyl, heterocyclyl-(C 1 -C 18 )alkyl, aryl-(C 1 -C 18 )alkyl, (C 3 -C 12 )cycloalkyl-(C 1 -C 18 )alkyl, (C 1 -C 18 )alkoxycarbonyl-(C 1 -C 18 )alkyl, or (C 1 -C 18 )alkoxycarbonyl-(C 3 -C 12 )cycloalkyl-(C 1 -C 18 )alkyl, or

a radical of the formula —NR a R b or —N═CR c R d ,

where, in the former 2 radicals, each of the R a , R b , R c and R d radicals is independently hydrogen, (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, benzyl, substituted benzyl, phenyl or substituted phenyl,

or R a and R b together with the nitrogen atom may form a 3- to 8-membered heterocycle which, in addition to the nitrogen atom, may contain one or two further ring heteroatoms from the group of N, O and S and which is unsubstituted or substituted by one or more radicals from the group of (C 1 -C 4 )-alkyl and (C 1 -C 4 )-haloalkyl,

or R c and R d together with the carbon atom are a 3- to 8-membered carbocyclic or heterocyclic radical which may contain 1 to 3 ring heteroatoms from the group of N, O and S, where the carbocyclic or heterocyclic radical is unsubstituted or substituted by one or more radicals from the group of (C 1 -C 4 )-alkyl and (C 1 -C 4 )-haloalkyl,

m is a number from 0 to 5,

and

p is 0, 1 or 2.

2 . The compound of the general formula (I) or salt thereof as claimed in claim 1 ,

in which

R 1 is heteroaryl, where the heteroaryl radical is unsubstituted or substituted by halogen, cyano, nitro, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 4 )alkynyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkenyl, (C 1 -C 4 )alkoxy or (C 1 -C 4 )alkylS(O) p , where the latter seven radicals are unsubstituted or are substituted by one or more radicals from the group of halogen, cyano, (C 1 -C 4 )alkoxy and (C 1 -C 4 )alkylS(O) p ,

R 2 is hydrogen, halogen, cyano, nitro, (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkenyl, (C 1 -C 4 )alkoxy or (C 1 -C 4 )alkylS(O) p , where the latter seven radicals are unsubstituted or are substituted by one or more radicals from the group of halogen, cyano, (C 1 -C 4 )alkoxy and (C 1 -C 4 )alkylS(O) p ,

R 3 is hydrogen or (C 1 -C 4 )alkyl,

R 4 is hydrogen, (C 1 -C 16 )alkyl, (C 1 -C 16 )haloalkyl, (C 1 -C 16 )cyanoalkyl, (C 2 -C 16 )alkenyl, (C 2 -C 16 )alkynyl, (C 3 -C 12 )cycloalkyl, (C 3 -C 12 )cycloalkenyl, aryl, heteroaryl, (C 1 -C 16 )alkoxy-(C 1 -C 16 )alkyl, (C 1 -C 16 )haloalkoxy-(C 1 -C 16 )alkyl, (C 1 -C 16 )alkoxy-(C 1 -C 16 )haloalkyl, (C 1 -C 16 )alkylthio-(C 1 -C 16 )alkyl, (C 1 -C 16 )haloalkylthio-(C 1 -C 16 )alkyl, (C 2 -C 16 )haloalkenyl, (C 2 -C 16 )haloalkynyl, heterocyclyl-(C 1 -C 16 )alkyl, aryl-(C 1 -C 16 )alkyl, (C 3 -C 12 )cycloalkyl-(C 1 -C 16 )alkyl, (C 1 -C 16 )alkoxycarbonyl-(C 1 -C 16 )alkyl, or (C 1 -C 16 )alkoxycarbonyl-(C 3 -C 12 )cycloalkyl-(C 1 -C 16 )alkyl,

m is a number from 0 to 4,

and

p is 0, 1 or 2.

3 . The compound of the general formula (I) or salt thereof as claimed in claim 1 ,

in which

R 1 is heteroaryl, where the heteroaryl radical is unsubstituted or mono- or polysubstituted by halogen, cyano, methyl, ethyl, CF 3 , CF 2 Cl, CH 2 F, CHF 2 , OCH 3 , OCF 3 , SCH 3 , SOCH 3 , SO 2 CH 3 or SCF 3 ,

R 2 is hydrogen, halogen, cyano, methyl, ethyl, CF 3 , CF 2 Cl, CH 2 F, CHF 2 , OCH 3 , OCF 3 , SCH 3 , SOCH 3 , SO 2 CH 3 or SCF 3 ,

R 3 is hydrogen, CH 2 CH 3 or CH 3 ,

R 4 is hydrogen, (C 1 -C 12 )alkyl, (C 1 -C 12 )haloalkyl, (C 1 -C 12 )cyanoalkyl, (C 2 -C 12 )alkenyl, (C 2 -C 12 )alkynyl, (C 3 -C 12 )cycloalkyl, (C 3 -C 12 )cycloalkenyl, aryl, heteroaryl, (C 1 -C 12 )alkoxy-(C 1 -C 12 )alkyl, (C 1 -C 12 )haloalkoxy-(C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxy-(C 1 -C 12 )haloalkyl, (C 1 -C 12 )alkylthio-(C 1 -C 12 )alkyl, (C 1 -C 12 )haloalkylthio-(C 1 -C 12 )alkyl, (C 2 -C 12 )haloalkenyl, (C 2 -C 12 )haloalkynyl, heterocyclyl-(C 1 -C 12 )alkyl, aryl-(C 1 -C 12 )alkyl, (C 3 -C 12 )cycloalkyl-(C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxycarbonyl-(C 1 -C 12 )alkyl, or (C 1 -C 12 )alkoxycarbonyl-(C 3 -C 12 )cycloalkyl-(C 1 -C 12 )alkyl,

and

m is 0, 1, 2 or 3.

4 . The compound of the general formula (I) or salt thereof as claimed in claim 1 ,

in which

R 1 is pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrazin-2-yl, pyrazin-3-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyridazin-3-yl, pyridazin-4-yl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl, 1,2,3-triazin-4-yl, 1,2,3-triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- and 1,2,6-oxazinyl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,3-thiazol-5-yl, 1H-pyrrol-1-yl, 1H-pyrrol-2-yl, 1H-pyrrol-3-yl, furan-2-yl, furan-3-yl, thien-2-yl, thien-3-yl, 1H-imidazol-1-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 1H-imidazol-5-yl, 1H-pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-1,2,3-triazol-1-yl, 1H-1,2,3-triazol-4-yl, 1H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1H-1,2,4-triazol-1-yl, 1H-1,2,4-triazol-5-yl, 4H-1,2,4-triazol-3-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,2,5-oxadiazol-3-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1,2,4-thiadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,5-thiadiazol-3-yl, 1,2,5-thiadiazol-3-yl, 1,2,3-thiadiazol-4-yl, or 1,2,3-thiadiazol-3-yl, which is unsubstituted or mono- or polysubstituted by halogen, cyano, methyl, CF 3 , CF 2 Cl, CH 2 F, CHF 2 , OCH 3 , OCF 3 , SCH 3 , SOCH 3 , SO 2 CH 3 or SCF 3 ,

R 2 is hydrogen, fluorine, chlorine, bromine, iodine, CN, methyl, ethyl, CF 3 ,CF 2 Cl, CH 2 F, CHF 2 , OCH 3 , OCF 3 , SCH 3 , SOCH 3 , SO 2 CH 3 or SCF 3 ,

R 3 is hydrogen or CH 3 ,

R 4 is hydrogen, (C 1 -C 10 )alkyl, (C 1 -C 10 )haloalkyl, (C 1 -C 10 )cyanoalkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 9 )cycloalkyl, (C 3 -C 9 )cycloalkenyl, aryl, heteroaryl, (C 1 -C 10 )alkoxy-(C 1 -C 10 )alkyl, (C 1 -C 10 )haloalkoxy-(C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxy-(C 1 -C 10 )haloalkyl, (C 1 -C 10 )alkylthio-(C 1 -C 10 )alkyl, (C 1 -C 10 )haloalkylthio-(C 1 -C 10 )alkyl, (C 2 -C 18 )haloalkenyl, (C 2 -C 18 )haloalkynyl, heterocyclyl-(C 1 -C 10 )alkyl, aryl-(C 1 -C 10 )alkyl, (C 3 -C 9 )cycloalkyl-(C 1 -C 10 )alkyl, (C 1 -C 10 )alkoxycarbonyl-(C 1 -C 10 )alkyl or (C 1 -C 10 )alkoxycarbonyl-(C 3 -C 9 )cycloalkyl-(C 1 -C 10 )alkyl,

and

m is 0, 1, 2 or 3.

5 . The compound of the general formula (I) or salt thereof as claimed in claim 1 ,

in which

R 1 is selected from the group consisting of Q-1.1 to Q-1.59

R 2 is hydrogen, fluorine, chlorine, bromine, iodine, cyano, methyl, CF 3 , CH 2 F, CHF 2 , OCH 3 , OCF 3 , SCH 3 , SOCH 3 , SO 2 CH 3 or SCF 3 ,

R 3 is hydrogen,

R 4 is hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, n-pentyl, phenyl, benzyl, CH 2 (4-Cl-Ph), CH 2 (4-F-Ph), CH 2 (4-MeO-Ph), 2-methoxyethyl, tetrahydrofuran-2-yl-methyl, tetrahydrofuran-3-ylmethyl, tetrahydropyran-2-ylmethyl, tetrahydropyran-3-ylmethyl, tetrahydropyran-4-ylmethyl, methylpropionate-3-yl, ethylpropionate-3-yl, methylacetate-2-yl, ethylacetate-2-yl, methylpivalate-2-yl, ethylpivalate-3-yl, methyl-2-methylpropanoate-3-yl, methyl-2,2-dimethylpropanoate-3-yl, ethyl-2-methylpropanoate-3-yl, methyl-2-propanoate-2-yl, ethyl-2-propanoate-2-yl, methylacet-2-yl, ethylacetate-2-yl, methyl-1-methylcyclopropanecarboxylate-2-yl, ethyl-1-methylcyclopropane-carboxylat-2-yl, 2-(dimethylamino)ethyl, oxetan-3-yl, (3-methyloxetan-3-yl)methyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, 2-fluoroethyl, 2,2,3,3,3-pentafluoropropyl, cyclopropylmethyl, 1-cyclopropylethyl, (1-methylcyclopropyl)methyl, (2,2-dichloro-cyclopropyl)methyl, (2,2-dimethylcyclopropyl)methyl, allyl, propargyl (prop-2-yn-1-yl), 2-chloroprop-2-en-1-yl, 3-phenylprop-2-yn-1-yl, 3,3-dichloroprop-2-en-1-yl, 3,3-dichloro-2-fluoroprop-2-en-1-yl, methylprop-2-yn-1-yl, 2-methylprop-2-en-1-yl, but-2-en-1-yl, but-3-en-1-yl, but-2-yn-1-yl, but-3-yn-1-yl, 4-chlorobut-2-yn-1-yl, 3-methylbut-2-en-1-yl, 3-methylbut-1-en-1-yl, (2E)-1-methylbut-2-en-1-yl, (E)-pent-3-en-2-yl or (Z)-pent-3-en-2-yl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, heptan-2-yl, isobutyl, 1,3-dioxolan-2-ylmethyl or 1-ethyl-5-methyl-1H-pyrazole-4-methyl,

m is 0, 1, 2 or 3.

6 . The compound of the general formula (I) or salt thereof as claimed in claim 1 ,

in which

R 1 is selected from the group consisting of Q-1.1 to Q-1.59

and (R 2 ) m -phenyl is selected from the group consisting of Q-2.1 to Q-2.53

R 3 is hydrogen,

R 4 is hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, n-pentyl, phenyl, benzyl, CH 2 (4-Cl-Ph), CH 2 (4-F-Ph), CH 2 (4-MeO-Ph), 2-methoxyethyl, tetrahydrofuran-2-yl-methyl, tetrahydrofuran-3-ylmethyl, tetrahydropyran-2-ylmethyl, tetrahydropyran-3-ylmethyl, tetrahydropyran-4-ylmethyl, methylpropionate-3-yl, ethylpropionate-3-yl, methylacetate-2-yl, ethylacetate-2-yl, methylpivalate-2-yl, ethylpivalate-3-yl, methyl-2-methylpropanoate-3-yl, methyl-2,2-dimethylpropanoate-3-yl, ethyl-2-methylpropanoate-3-yl, methyl-2-propanoate-2-yl, ethyl-2-propanoate-2-yl, methylacetate-2-yl, ethylacetate-2-yl, methyl-1-methylcyclopropanecarboxylate-2-yl, ethyl-1-methylcyclopropanecarboxylat-2-yl, 2-(dimethylamino)ethyl, oxetan-3-yl, (3-methyloxetan-3-yl)methyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, 2-fluoroethyl, 2,2,3,3,3-pentafluoropropyl, cyclopropylmethyl, 1-cyclopropylethyl, (1-methylcyclo-propyl)methyl, (2,2-dichlorocyclopropyl)methyl, (2,2-dimethylcyclopropyl)methyl, allyl, propargyl (prop-2-yn-1-yl), 2-chloroprop-2-en-1-yl, 3-phenylprop-2-yn-1-yl, 3,3-dichloroprop-2-en-1-yl, 3,3-dichloro-2-fluoroprop-2-en-1-yl, methylprop-2-yn-1-yl, 2-methylprop-2-en-1-yl, but-2-en-1-yl, but-3-en-1-yl, but-2-yn-1-yl, but-3-yn-1-yl, 4-chlorobut-2-yn-1-yl, 3-methylbut-2-en-1-yl, 3-methylbut-1-en-1-yl, (2E)-1-methylbut-2-en-1-yl, (E)-pent-3-en-2-yl or (Z)-pent-3-en-2-yl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, heptan-2-yl, isobutyl, 1,3-dioxolan-2-ylmethyl or 1-ethyl-5-methyl-1H-pyrazole-4-methyl.

7 . The compound of the general formula (I) or salt thereof as claimed in claim 1 ,

in which

R 1 is selected from the group consisting of Q-1.1 to Q-1.59

and (R 2 ) m -phenyl is selected from the group consisting of Q-2.1 to Q-2.53

R 3 is hydrogen,

R 4 is hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, n-pentyl, phenyl, benzyl, CH 2 (4-Cl-Ph), CH 2 (4-F-Ph), CH 2 (4-MeO-Ph), 2-methoxyethyl, tetrahydrofuran-2-yl-methyl, tetrahydrofuran-3-ylmethyl, tetrahydropyran-2-ylmethyl, tetrahydropyran-3-ylmethyl, tetrahydropyran-4-ylmethyl, methylpropionate-3-yl, ethylpropionate-3-yl, methylacetate-2-yl, ethylacetate-2-yl, methylpivalate-2-yl, ethylpivalate-3-yl, methyl-2-methylpropanoate-3-yl, methyl-2,2-dimethylpropanoate-3-yl, ethyl-2-methylpropanoate-3-yl, methyl-2-propanoate-2-yl, ethyl-2-propanoate-2-yl, methylacetate-2-yl, ethylacetate-2-yl, methyl-1-methylcyclopropanecarboxylate-2-yl, ethyl-1-methylcyclopropanecarboxylat-2-yl, 2-(dimethylamino)ethyl, oxetan-3-yl, (3-methyloxetan-3-yl)methyl, 2,2,2-trifluoroethyl, 2,2-difluoroethyl, 2-fluoroethyl, 2,2,3,3,3-pentafluoropropyl, cyclopropylmethyl, 1-cyclopropylethyl, (1-methylcyclo-propyl)methyl, (2,2-dichlorocyclopropyl)methyl, (2,2-dimethylcyclopropyl)methyl, allyl, propargyl (prop-2-yn-1-yl), 2-chloroprop-2-en-1-yl, 3-phenylprop-2-yn-1-yl, 3,3-dichloroprop-2-en-1-yl, 3,3-dichloro-2-fluoroprop-2-en-1-yl, methylprop-2-yn-1-yl, 2-methylprop-2-en-1-yl, but-2-en-1-yl, but-3-en-1-yl, but-2-yn-1-yl, but-3-yn-1-yl, 4-chlorobut-2-yn-1-yl, 3-methylbut-2-en-1-yl, 3-methylbut-1-en-1-yl, (2E)-1-methylbut-2-en-1-yl, (E)-pent-3-en-2-yl or (Z)-pent-3-en-2-yl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, heptan-2-yl, isobutyl, 1,3-dioxolan-2-ylmethyl or 1-ethyl-5-methyl-1H-pyrazole-4-methyl.

8 . A plant-protecting composition, comprising:

at least one compound of the general formula (I) or salt thereof as claimed in claim 1 ; and

at least one agrochemical.

9 . The composition as claimed in claim 8 , comprising at least one herbicide.

10 . A method of reducing phytotoxic effects of pesticides on plants, the method comprising applying one or more compounds of the general formula (I) or salt thereof as claimed in claim 1 or of the composition as claimed in claim 8 to the plants.

11 . A method of reducing phytotoxic effects of pesticides on plants, the method comprising:

applying one or more compounds of the general formula (I) or salt thereof as claimed in claim 1 to the plants; and

applying pesticides to the plants, wherein the pesticides are deployed simultaneously or sequentially relative to applying the one or more compounds of the general formula (I) or salt thereof.

12 . The method as claimed in claim 11 , wherein the pesticides are one or more herbicides.

13 . The method as claimed in claim 11 , characterized in that one or more compounds of the formula (I) or salt thereof as claimed in claim 1 are applied to the plants, parts of the plants, or seeds or seed material thereof.

14 . The composition as claimed in claim 8 , further comprising at least one formulation auxiliary.

15 . The method of claim 10 , further comprising use of at least one herbicide.

16 . The method of claim 13 , further comprising use of at least one herbicide.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 26, 2023

From: MÜLLER, THOMAS, DR.; REINGRUBER, ANNA MARIA, DR.; FRACKENPOHL, JENS, DR.; HELMKE, HENDRIK, DR.; DITTGEN, JAN, DR.

To: BAYER AKTIENGELLSCHAFT

Reel/Frame 063447/0227 →

Priority Claims (1)

EP 20206033 · Nov 5, 2020 · regional

Continuity (1)

Related Publication 20230397604A1 · Dec 14, 2023

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