Dosage regimen of amlodipine
There is a dosage regimen for amlodipine for use in the treatment of hypertension.
1 . A method for treating hypertension in a patient with a dosage regimen, wherein the dosage regimen comprises:
i. for a period of from about 7 days to about 14 days:
a) administering an initial daily dose of 1 to 10 mg amlodipine to the patient;
b) recording patient's blood pressure readings on at least 3 separate days, using a blood pressure device;
c) recording any side-effects experienced by the patient on at least 3 separate days;
ii. increasing or decreasing the daily dose of amlodipine by between 1 mg and 2.5 mg, or maintaining the daily dose of amlodipine, based on the blood pressure readings and the patient reported side-effects; and
iii. repeating steps (i) and (ii) with either the increased, decreased or maintained daily dose replacing the initial daily dose in step (a) for a number of times until a specified patient treatment period has elapsed or until a target blood pressure is reached.
2 . The method according to claim 1 , wherein step b) includes a determination of a moving average of the blood pressure readings and the increasing, decreasing or maintaining the daily dose in step (ii) is based on the moving average of the blood pressure.
3 . The method according to claim 2 , wherein the moving average is a 3-day moving average, wherein the days are consecutive.
4 . The method according to claim 1 , wherein the period in step (i) is either pre-determined or is determined by the time taken to reach less than 10% variability in the moving average blood pressure.
5 . The method according to claim 1 , wherein the blood pressure readings are recorded at least every other day.
6 . The method according to claim 1 , wherein blood pressure readings are recorded at the same time each day.
7 . The method according to claim 1 , wherein the patient's initial daily dose is determined based on their medical history and/or history of prior side-effects when taking amlodipine.
8 . The method according to claim 1 , wherein the patient's initial daily dose is determined by a physician or delegated health care professional.
9 . The method according to claim 1 , wherein the patient's initial daily dose is 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg or 6 mg.
10 . The method according to claim 1 , wherein the patients are selected for treatment if the patients have had a diagnosis of hypertension according to NICE/BIHS CG127 criteria, and wherein the patients have already had conducted 24h ambulatory blood pressure monitoring (ABPM) recording or home blood pressure monitoring.
11 . The method according to claim 1 , wherein the increasing or decreasing is in an increment of 1 mg, 2 mg or 2.5 mg.
12 . The method according to claim 1 , wherein the increasing or decreasing in step (ii) includes a comparison of the blood pressure with a control blood pressure and/or a dose/response curve for amlodipine personalised for the patient.
13 . The method according to claim 1 , wherein step (ii) is carried out by a physician or delegated health care professional or wherein step (ii) is carried out by software executed on an electronic device.
14 . The method according to claim 1 , wherein the recording of blood pressure is onto an electronic device.
15 . The method according to claim 14 , wherein data are transferred from the blood pressure device to the electronic device electronically and automatically.
16 . The method according to claim 1 , wherein the modification of the dose in step (ii) is based on patient tolerability of the side-effects.
17 . The method according to claim 1 , wherein the side-effects recorded by the patient are selected from the group consisting of one or more of swollen ankles, feet, and legs.
18 . The method according to claim 1 , wherein the side-effects recorded by the patient include hypotension.
19 . The method according to claim 1 , wherein the side-effects recorded by the patient include hypotension and one or more selected from the group consisting of swollen ankles, feet, and legs.
20 . The method according to claim 1 , wherein the recording of the side-effects is carried out daily.
21 . The method according to claim 1 , wherein the amlodipine is administered in solid form and via the oral route.
22 . The method of claim 1 comprising recording the patient's blood pressure on at least 3 separate days and calculating a moving average of the blood pressure and producing an amlodipine dosage regimen based on the moving average of the blood pressure readings and the patient reported side effects.