Granted Patent B2

US 12,667,724 · App. 18/890,394 · Granted Jun 30, 2026

Inventors: Daniel Månsson (Simrishamn, SE); Erik Rehn (Enebyberg, SE)

Assignee: Flow Neuroscience, Inc.

A61N1/36025A61K31/136A61K31/137A61K31/15A61K31/343A61K31/443A61K31/495A61P25/24

Abstract

Claims (30)

1 . A method of treating depression in a patient in need thereof comprising administering to the patient:

(a) a selective serotonin reuptake inhibitor (SSRI); and

(b) trans-cranial electrical stimulation by applying current in a direction of flow from a first electrode disposed over a region of a left prefrontal cortex of the patient to a second electrode disposed over a region of a right prefrontal cortex of the patient, the first electrode and the second electrode each having a conductive surface area greater than 20 cm 2 and less than 25 cm 2 ;

wherein a lower dosage of the SSRI is administered to the patient as compared to an individual receiving the SSRI alone.

2 . The method of claim 1 , wherein the lower dosage comprises one or more of a lower quantity of the SSRI, a frequency of administration of the SSRI, and a duration over which the SSRI is administered.

3 . The method of claim 1 , wherein the SSRI comprises fluoxetine.

4 . The method of claim 3 , wherein the lower dosage of the fluoxetine comprises 42.5 mg or less.

5 . The method of claim 3 , wherein the lower dosage of the fluoxetine is at most 5 mg less than the dosage of the fluoxetine alone.

6 . The method of claim 3 , wherein the lower dosage of the fluoxetine is at most 11% less than the dosage, by milligrams, of the fluoxetine alone.

7 . The method of claim 3 , wherein the lower dosage of the fluoxetine is 50-99% of the dosage, by milligrams, of the fluoxetine alone.

8 . The method of claim 1 , wherein the SSRI comprises citalopram.

9 . The method of claim 8 , wherein the lower dosage of the citalopram comprises 18.9 mg or less.

10 . The method of claim 8 , wherein the lower dosage of citalopram is at most 2.2 mg less than the dosage of the citalopram alone.

11 . The method of claim 8 , wherein the lower dosage of citalopram is at most 11% less than the dosage, by milligrams, of the citalopram alone.

12 . The method of claim 8 , wherein the lower dosage of the citalopram is 1-49% of the dosage, by milligrams, of the citalopram alone.

13 . The method of claim 8 , wherein the lower dosage of citalopram is cessation of citalopram.

14 . The method of claim 1 , wherein the SSRI comprises sertraline.

15 . The method of claim 14 , wherein the lower dosage of the sertraline comprises 81.4 mg or less.

16 . The method of claim 14 , wherein the lower dosage of sertraline is at most 23.7 mg less than the dosage of the sertraline alone.

17 . The method of claim 14 , wherein the lower dosage of sertraline is at most 23% less than the dosage, by milligrams, of the sertraline alone.

18 . The method of claim 14 , wherein the lower dosage of the sertraline is 1-49% of the dosage, by milligrams, of the sertraline alone.

19 . The method of claim 14 , wherein the lower dosage of the sertraline is 50-99% of the dosage, by milligrams, of the sertraline alone.

20 . The method of claim 14 , wherein the lower dosage of sertraline is cessation of sertraline.

21 . The method of claim 1 , wherein the region of the left prefrontal cortex is a left dorsolateral prefrontal cortex of the patient and the region of the right prefrontal cortex is a right dorsolateral prefrontal cortex of the patient.

22 . The method of claim 1 , wherein the current has an amplitude in a range between about 0.5 milliamps (mA) and about 4 mA.

23 . The method of claim 1 , wherein the applying the current includes ramping up the current from 0 mA to a maximum amplitude over a first period of time, delivering the current at the maximum amplitude for a second period of time, and ramping down the current from the maximum amplitude to 0 mA over a third period of time.

24 . The method of claim 1 , wherein the administering the trans-cranial electrical stimulation includes administering the trans-cranial electrical stimulation over a plurality of treatment sessions, each treatment session of the plurality of treatment sessions including the applying of the current in the direction of flow for a predetermined amount of time.

25 . The method of claim 24 , wherein the administering the trans-cranial electrical stimulation over the plurality of treatment sessions includes administering at least three treatment sessions of the plurality of treatment sessions per week.

26 . The method of claim 24 , wherein the predetermined amount of time is between 1 minute and 50 minutes.

27 . The method of claim 1 , wherein a current density of the current being applied across a surface of the first electrode is greater than about 0.08 mA/cm 2 and less than about 0.1 mA/cm 2 .

Assignments (2)

Continuity (4)

References Cited (80)